Metabolism of 2-chloro-1-(2,4,5-trichlorophenyl)vinyl dimethyl phosphate in the dog and rat

An enzyme catalysing the hydrolysis of phosphoric acid diesters in rat liver

“…One of the primary mammalian metabolites of insecticidal phosphoric acid triesters such as 2-chloro-l-(2,4,5-trichlorophenyl)vinyldimethylphosphate is the corresponding diester, in this case 2-chloro -1 -(2,4,5 -trichlorophenyl)vinyl methyl hydrogen phosphate (I) (Akintonwa & Hutson, 1967;. In a study of the further metabolism of phosphate diesters in mammalian liver an enzyme catalysing the hydrolysis of compound (I) to 2,4,5-trichlorophenacyl chloride was found in the soluble fraction of rat and pig liver homogenates.…”

Effect of Refining Processes on Magnitude and Nature of Fenitrothion and Pirimiphos-Methyl Residues in Maize Oil and Bioavailability of their Cake Residues on Rats*

“…The product was purified by preparative thin layer chromatography (TLC) (Silica gel 60 F 254 pre-coated plates 20×20 cm layer thickness 0.5 mm, Merck, Germany). The prepared 14 C-fenitrothion had a specific activity 2.96 MBq/mg and a radiometric purity 98 % (19) Pure fenitrothion (non-labelled) and its main degradation products were synthesized in our laboratory for comparison purposes (20)(21)(22) (Fig 1). …”

A newin vitromethod for testing plant metabolism in mutagenicity studies

“…Accordingly the genetic activity of dichlorvos was thought to result from the presence of a vinylidene chloride group in its molecule (Carere et al, 1978;Morpurgo et al, 1977). Tetrachlorvinphos has a vinyl group very similar to that in the dichlorvos molecule, but its metabolism and genetic activity in plants and animals are completely different (Akintonwa and Hutson, 1967;Beynon et al, 1970). Maleic hydrazide is of interest because it is a chromosomebreaking agent for plant cells but not for animal cells, and a product of plant metabolism could be hypothesized.…”