Metabolism of Dimethyl Sulphoxide to Dimethyl Sulphone in the Rat and Man

Hücker, H.; Ahmad, Parvez; Miller, E.; Brobyn, Richard

doi:10.1038/209619a0

Cited by 31 publications

(17 citation statements)

References 2 publications

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“…After cutaneous administration of DMSO_35S to man, DMSO disap peared from the blood in 30-48 hours. Serum DMS02 reached peak values after 36-72 hours and had disappeared after 312 hours (32,35). Denko et al (36) believe that the sulfur atom in DMSO follows the same metabolic pathways as organic sulfur.…”

Section: Absorptionmentioning

confidence: 96%

“…Examination of 24-hour urine collections after intraperitoneal in jections of DMSO_35S to rats disclosed a recovery of 12.8% as dimethyl sulfone (29 ). In man, dermal administration of DMSO_35S showed that all the DMSO had been excreted within 48 hours while DMS02, first noted 8 hours after treatment, continued to be excreted for 480 hours (32,35). A total of 13% of the dose appeared in the urine as DMSO and about 18% as DMS02• Following oral administration, the urine recovery of DMSO was 50.8% and 22% for DMS02• Kolb et al (26,27) recovered 80% of the orig inal dose of DMSO within 8 days after intravenous administration to man but only 50% over a 10-15-day period after cutaneous application.…”

Section: Absorptionmentioning

confidence: 98%

“…Mayer et al (91) abraded a 4-5 cm segment of distal ileum of the rat along the mesen teric border with gauze until most of the serosal layer was wiped off. This led to development of adhesions in 100% of the control rats within [30][31][32][33][34][35] days. But, when daily intraperitoneal injections of the following agents were given postoperatively for 35 days, the incidence of adhesions was: DMSO (1 gjkg/day), 20%; DMSO-cortisone, 80% incidence; cortisone (2.5 mg/kg/day), 100%; and saline solution, 100%.…”

Section: Pharmacologymentioning

confidence: 99%

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The Pharmacology of Dimethyl Sulfoxide

David¹

1972

Annu. Rev. Pharmacol.

172

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Section: Absorptionmentioning

confidence: 96%

Section: Absorptionmentioning

confidence: 98%

Section: Pharmacologymentioning

confidence: 99%

See 1 more Smart Citation

The Pharmacology of Dimethyl Sulfoxide

David¹

1972

Annu. Rev. Pharmacol.

172

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“…Early pharmacokinetic studies showed that *64% of [ 35 S]Me 2 SO 2 (21 mg/kg) was excreted within 24 h upon intraperitoneal administration to rats [236]. In a more recent study, the distribution of Me 2 SO 2 administered orally for 7 days using a 35 S radioisotope tracer found that [ 35 S] Me 2 SO 2 (470 mg/kg/day) was excreted in urine (*70%) and feces (*10%) [237].…”

Section: Antioxidant and Pro-oxidant Effects Of Oxo-sulfur Compounds mentioning

confidence: 99%

Antioxidant and Anticancer Properties and Mechanisms of Inorganic Selenium, Oxo-Sulfur, and Oxo-Selenium Compounds

Ramoutar

Brumaghim

2010

Cell Biochem Biophys

102

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Inorganic selenium and oxo-sulfur compounds are widely available in dietary supplements and have been extensively studied for their antioxidant and anticancer properties. Although many in vivo and clinical trials have been conducted using these compounds, their biochemical and chemical mechanisms of efficacy are the focus of much current research. This review discusses the ability of inorganic selenium compounds, such as selenite, and selenate, to prevent damage from reactive oxygen species as well as their ability to promote cell death by reactive oxygen species generation. Oxo-sulfur and selenium compounds, such as allicin, dimethyl sulfone, methionine sulfoxide, and methylselenenic acid also have similar abilities to act as both antioxidants and pro-oxidants, but the mechanisms for these behaviors are distinctly different from those of the inorganic selenium compounds. The antioxidant and pro-oxidant properties of these small-molecule sulfur and selenium compounds are extremely complex and often greatly depend on experimental conditions, which may explain contradictory literature reports of their efficacy.

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“…It is also reported as an oxidation product of dimethylsulfoxide in the rat, rabbit and humans (Williams et al 1965(Williams et al , 1966Hucker et al 1966;Egorin et al 1998). Dimethylsulfone has been reported as an intermediate in the degradation of dimethylsulfide by Acinetobacter (Horinouchi et al 1997) and of dimethylsulfoxide [(CH 3 ) 2 SO] by Rhodococcus (Kayser et al 1993;Omori et al 1995).…”

Section: Introductionmentioning

confidence: 96%

Dimethylsulfone as a growth substrate for novel methylotrophic species of Hyphomicrobium and Arthrobacter

et al. 2000

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Dimethylsulfone is a major product of the chemical oxidation in the atmosphere of the principal biogenic sulfur gas, dimethylsulfide, but no studies have been reported on the mechanisms for its microbiological degradation. Three novel strains of bacteria have been isolated from enrichment cultures provided with dimethylsulfone as the only carbon and energy substrate. These are novel facultatively methylotrophic species of Hyphonmicrobium and Arthobacter, capable of growth on a range of one-carbon substrates. Cell-free extracts contained activities of enzymes necessary for a reductive/oxidative pathway for dimethylsulfone degradation: membrane-bound-dimethylsulfone and dimethylsulfoxide reductases, dimethylsulfide monooxygenase, and methanethiol oxidase. Enzymatic evidence is also presented for the subsequent oxidation of formaldehyde by formaldehyde and formate dehydrogenases in the Hyphomicrobium strain and by a dissimilatory ribulose monophosphate cycle in the Arthrobacter strains. The strains also grew on dimethylsulfoxide and dimethylsulfide, and dimethylsulfide-grown bacteria oxidized dimethylsulfide and dimethylsulfoxide but not dimethylsulfone. Formaldehyde assimilation was effected in the Hyphomicrobium strain by the serine pathway, but enzymes of the ribulose monophosphate cycle for formaldehyde assimilation were present in the Arthrobacter strains grown on dimethylsulfone. In contrast, one of the Arthrobacter strains was shown to switch to the serine pathway during growth on methanol. Growth yields on dimethylsulfone and formaldehyde were consistent with the occurrence of the serine pathway in Hyphomicrobium strain S1 and the ribulose monophosphate cycle in Arthrobacter strain TGA, and with the proposed reductive pathway for dimethylsulfone degradation in both.

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Metabolism of Dimethyl Sulphoxide to Dimethyl Sulphone in the Rat and Man

Cited by 31 publications

References 2 publications

The Pharmacology of Dimethyl Sulfoxide

The Pharmacology of Dimethyl Sulfoxide

Antioxidant and Anticancer Properties and Mechanisms of Inorganic Selenium, Oxo-Sulfur, and Oxo-Selenium Compounds

Dimethylsulfone as a growth substrate for novel methylotrophic species of Hyphomicrobium and Arthrobacter

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