Metabolism of Methocarbamol in the Rat, Dog, and Human

Comparative Pharmacokinetics of Chlorphenesin Carbamate and Methocarbamol in Man

“…Bruce et ul. (21) recently reported that the major metabolites of methocarbamol in man are glucuronide and sulfate conjugates of the drug, 3-(o-hydroxyphenoxy)-1,2-propanediol-lcarbamate, and 3-(p-hydroxy-o-methoxyphenoxy)-1,2-propanediol-I-carbamate. None of these compounds responded in the present analytical procedure.…”

“…In the former case, formation of the 0-glucuronide represents the only important route of drug elimination and is the ratelimiting process measured (7). With methocarh;lmol, Bruce et al (21) showed that conjugates of the drug. of 3-(o-hydroxyphenoxy)-1,2-propanediol-1-carbamate, and of 3-(p-hydroxy-o-methoxyphenoxy)-1.2-propanediol-1-carbamate are the m$or metabolites excreted in human urine along with small amounts of unidentified materials.…”

“…(24) recently showed that plasma levels of rnephenesin in the dog can be described by the same model. Similarly, Bruce et al (21) invoked this model in determining the half-life for total methocarbamolrelated materials (radioactivity) in man.…”

Determination of methocarbamol concentration in human plasma by high performance liquid chromatography–tandem mass spectrometry

“…Methocarbamol is easily absorbed from the intestine and widely distributed in all body tissues, especially the liver and kidney [4]. Its metabolism is similar in rats, dogs, and humans, which is ring hydroxylation and o-demethylation at phase I and conjugation at phase II [4,5].…”

Electrochemical Behaviors of Methocarbamol at an Acetylene Black-Ionic Liquid Modified Carbon Paste Electrode and its Electrochemical Determination

“…1,2 MET is easily absorbed from the intestine and widely distributed in all body tissues, especially the liver and the kidney. 3 Hence, it is very necessary to determine the amount of MET in drug formulations. To date, the widely used techniques for the determination of MET are high performance liquid chromatography (HPLC), 4,5 high performance liquid chromatography coupled with mass spectrometry (HPLC-MS), 6 spectrophotometry, 7 spectrophotometry-LC, 8 reversed phase liquid chromatography (RP-LC), 9 spectrofluorometric, 10 H-NMR spectroscopy 11 and the electrochemical method.…”