Metabolism of sodium oestrone [35S] sulphate in the rat

Dolly, J. Oliver; Curtis, C. G.; Dodgson, K. S.; Rose, F. A.

doi:10.1042/bj1190022p

Biochemical Journal

1970

DOI: 10.1042/bj1190022p

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Metabolism of sodium oestrone [35S] sulphate in the rat

J. Oliver Dolly¹,

C. G. Curtis²,

K. S. Dodgson³

et al.

Abstract: Intraperitoneal, intravenous or oral administration of sodium oestrone [3][4][5]

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1971

1976

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“…The present investigation pinpoints the liver as the principal site of this process at the dosages employed. A preliminary account of some of this work has already been made (Dolly, Curtis, Dodgson & Rose, 1970).…”

mentioning

confidence: 99%

Metabolism of sodium oestrone [35S]sulphate in the rat

Dolly¹,

Cg²,

Ks³

et al. 1971

Biochemical Journal

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Intraperitoneal, intravenous or oral administration of sodium oestrone [(35)S]-sulphate to male and female Medical Research Council hooded rats is followed by the rapid excretion of the bulk of the radioactivity in urine in the form of inorganic [(35)S]sulphate. Pre-treatment of rats with an antibiotic regimen does not affect the results except in the case of oral administration, when relatively large amounts of the dose are recovered as ester [(35)S]sulphate in faeces. Intravenous administration of the labelled ester to male and female rats with cannulae in bile duct and ureter gave results similar to those obtained with free-range animals. Only small amounts of radioactivity appeared in bile and this was mainly in the form of ester sulphate, including both oestrone [(35)S]sulphate and oestradiol-17beta 3[(35)S]-sulphate. Whole-body radioautography pinpointed the liver as the probable site of the desulphation of the sulphate ester and this was confirmed by liver and kidney perfusion experiments and by studies with rats in which kidney function had been eliminated by ligation of the renal pedicles.

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confidence: 99%

Metabolism of sodium oestrone [35S]sulphate in the rat

Dolly¹,

Cg²,

Ks³

et al. 1971

Biochemical Journal

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Chemistry of Biologically Active Sulfur Compounds

Kharasch

Arora

1976

Phosphorus and Sulfur and the Related Elements

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Metabolism of sodium oestrone [35S] sulphate in the rat

Abstract: Intraperitoneal, intravenous or oral administration of sodium oestrone [3][4][5]

Cited by 2 publications

References 19 publications

Metabolism of sodium oestrone [35S]sulphate in the rat

Metabolism of sodium oestrone [35S]sulphate in the rat

Chemistry of Biologically Active Sulfur Compounds

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