Metabolism of¹³C-Isomaltooligosaccharides in Healthy Men

Abstract

Isomaltooligosaccharides (IMO), sweeteners derived from corn-starch, selectively promote the growth of bifidobacteria in the human intestine. The metabolic fate of IMO in healthy men was investigated. The expiration rates of excess (13)CO2 and hydrogen of six men were measured while sedentary and while taking physical exercise after the (13)C-labeled IMO intakes. The breath H2 excretion kept at a constant state after IMO ingestion in the sedentary test and increased in the exercise test. The serum glucose and serum insulin increased 30 min after IMO ingestion. The (13)CO2 recoveries were 28.7% in the sedentary test and 60.9% in the exercise test. These recoveries were 70-80% compared those of maltose. These results indicated that a part of IMO was digested and the residual IMO was fermented by intestinal flora. The energy value of IMO might be about 75% of that of maltose.

Synthesis of long-chain isomaltooligosaccharides from tapioca starch and an in vitro investigation of their prebiotic properties

“…There have been several reports that isomaltose (IMO2) could be hydrolysed by brush border enzymes in the intestinal epithelium, while the digestibilities of isomaltotriose and panose were unclear. Oligosaccharides with longer chains, on the other hand, were more stable [35,36]. Thus, this property made both synthesized IMOs suitable for use as prebiotics to promote the growth of beneficial bacteria in the gastrointestinal tract, mainly promoting the Lactobacilli species.…”

The Low FODMAP Diet and Its Application in East and Southeast Asia

“…Isomalto-oligosaccharides (IMO) are partly hydolyzed although substantial proportion does enter the colon. 14,15 IMO are present in honey and, according to Japanese literature, some fermented foods such as miso, soy sauce, and saki, 14,16 but the actual concentrations are uncertain. IMO may also be added as a prebiotic/fiber to some food.…”

Production of isomaltooligosaccharides (IMO) using simultaneous saccharification and transglucosylation from starch and sustainable sources

“…Reduction in colonic pH also improves mineral absorption and inhibits lipogenesis [6]. Isomaltooligosaccharide (IMO) are considered as potential prebiotics and are reported to stimulate the growth of colonic bifidobacterium and lactobacilli in rats and humans [7][8][9][10]. They are antidiabetic, non-cariogenic and known to have a low glycemic index [11].…”