Metabolism of triglyceride-rich lipoproteins and lipid transfer to high-density lipoprotein in young obese and normal-weight patients with polycystic ovary syndrome

Rocha, Marco; Maranhão, Raul C.; Seydell, Talita Matttos; Barcellos, Cristiano Roberto Grimaldi; Baracat, E C; Hayashida, Sylvia Asaka Yamashita; Bydlowski, Sérgio Paulo; Marcondes, José Antônio Miguel

doi:10.1016/j.fertnstert.2008.12.044

Cited by 22 publications

(15 citation statements)

References 40 publications

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“…In a previous study performed in women with polycystic ovary syndrome [29], a correlation was found between insulin resistance, measured by the HOMA-IR index and that is associated with the syndrome, with the transfer of triglycerides to HDL. On the other hand, the action of both CETP and PLTP, that promote lipid transfer, was found to be altered in T1DM patients, and in another study CETP alterations were related with the presence of macrovascular disease [30].…”

Section: Discussionmentioning

confidence: 99%

Lipoprotein metabolism in patients with type 1 diabetes under intensive insulin treatment

et al. 2013

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BackgroundType 1 diabetes (T1DM) is frequently accompanied by dyslipidemia related with insulin-dependent steps of the intravascular lipoprotein metabolism. T1DM dyslipidemia may predispose to precocious cardiovascular disease and the lipid status in T1DM under intensive insulin treatment has not been sufficiently explored. The aim was to investigate the plasma lipids and the metabolism of LDL and HDL in insulin-treated T1DM patients with high glycemic levels.MethodsSixteen male patients with T1DM (26 ± 7 yrs) with glycated hemoglobin >7%, and 15 control subjects (28 ± 6 yrs) were injected with a lipid nanoemulsion (LDE) resembling LDL and labeled with 14C-cholesteryl ester and 3H-free-cholesterol for determination of fractional clearance rates (FCR, in h-1) and cholesterol esterification kinetics. Transfer of labeled lipids from LDE to HDL was assayed in vitro.ResultsLDL-cholesterol (83 ± 15 vs 100 ± 29 mg/dl, p=0.08) tended to be lower in T1DM than in controls; HDL-cholesterol and triglycerides were equal. LDE marker 14C-cholesteryl ester was removed faster from plasma in T1DM patients than in controls (FCR=0.059 ± 0.022 vs 0.039 ± 0.022h-1, p=0.019), which may account for their lower LDL-cholesterol levels. Cholesterol esterification kinetics and transfer of non-esterified and esterified cholesterol, phospholipids and triglycerides from LDE to HDL were also equal.ConclusionT1DM patients under intensive insulin treatment but with poor glycemic control had lower LDL-cholesterol with higher LDE plasma clearance, indicating that LDL plasma removal was even more efficient than in controls. Furthermore, HDL-cholesterol and triglycerides, cholesterol esterification and transfer of lipids to HDL, an important step in reverse cholesterol transport, were all normal. Coexistence of high glycemia levels with normal intravascular lipid metabolism may be related to differences in exogenous insulin bioavailabity and different insulin mechanisms of action on glucose and lipids. Those findings may have important implications for prevention of macrovascular disease by intensive insulin treatment.

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Section: Discussionmentioning

confidence: 99%

Lipoprotein metabolism in patients with type 1 diabetes under intensive insulin treatment

et al. 2013

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“…31 Tumor necrosis factor-alpha and IL-6 were determined by Multiplex-Based immunoassays-HSCYTO-60SK (Millipore Corp., Missouri 63304, USA). The intra-and interassay coefficients of variation for these two cytokines were 3.1% and 5.8%, respectively.…”

Section: Methodsmentioning

confidence: 99%

Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cardiovascular risk factors

Barcellos¹,

Rocha²,

Hayashida³

et al. 2015

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obJectIve: the aim of this study was to evaluate the influence of polycystic ovary syndrome (pcos) and obesity on circulating markers of low-grade inflammation-tumor necrosis factoralpha (TNF-α), interleukin 6 (IL-6) and high sensitive C-reactive protein (hsCRP)-in young women without major cardiovascular (cv) risk factors (diabetes, dyslipidemia and arterial hypertension). desIGn: twenty-five young women with pcos and 23 eumenorrheic women without major cv risk factors and matched for body mass index (bmI) were studied. they were subdivided according to bmI and pcos status and comparisons were made between the pcos and control groups, regardless of bmI, and between the obese and Lean groups, regardless of the presence of PCOS. RESULTS: Levels of TNF-α, IL-6 and hsCRP were similar between the pcos group and the control group (2.1 vs 1.9 pg/ml, p=0.397, 3.8 vs 5.7 pg/ml, p=0.805 and 0.9 vs 0.5 ng/ml, p=0.361, respectively). Levels of TNF-α were similar between the obese group and the lean group (2.1 vs 1.9 pg/ml, p=0.444). Levels of IL-6 and hscrp were higher in the obese group than in the lean group (8.7 vs 2.0, p <0.001 and 1.4 vs 0.2 ng/ml, p <0.001, respectively). concLusIon: obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cv risk factors.

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“…It was demonstrated that PCOS patients had higher LDLcholesterol and lower HDL [18]. Rocha et al found that the cholesteryl ester fractional clearance rate was reduced in both obese and nonobese PCOS groups as compared with the controls, meaning the risk of cardiovascular events was increased among PCOS independent of BMI [33]. In the study of Soare et al, the decreased HDL-C level was also mentioned as the most prevalent individual component among the measurements of metabolic syndrome in Brazilian patients with PCOS [34].…”

Section: Pcos Metabolic Disturbance and Long-term Consequencesmentioning

confidence: 99%

Polycystic ovary syndrome

Chen

Shi

2010

Front. Med. China

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Polycystic ovary syndrome (PCOS) is a common gynecologic endocrinopathy. The pathogenesis of PCOS is associated with both heredity and environment. PCOS has adverse impacts on female endocrine, reproduction, and metabolism. PCOS can impact women's reproductive health, leading to anovulatory infertility and higher rate of early pregnancy loss. PCOS has additional metabolic derangements, such as insulin resistance, impaired glucose tolerance, and dyslipidemia. The risks of diabetes, cardiovascular disease, hypertension, metabolic syndrome, and endometrial cancer among PCOS patients are significantly increased as well.

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Metabolism of triglyceride-rich lipoproteins and lipid transfer to high-density lipoprotein in young obese and normal-weight patients with polycystic ovary syndrome

Cited by 22 publications

References 40 publications

Lipoprotein metabolism in patients with type 1 diabetes under intensive insulin treatment

Lipoprotein metabolism in patients with type 1 diabetes under intensive insulin treatment

Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cardiovascular risk factors

Polycystic ovary syndrome

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