Metabolite characterization, antioxidant, anti-proliferative and enzyme inhibitory activities of Lophira lanceolata Tiegh. ex Keay extracts

Sinan, Kouadio Ibrahime; Martinović, Lara Saftić; Peršurić, Željka; Pavelić, Sandra Kraljević; Grbčić, Petra; Matulja, Dario; Etienne, Ouattara Katinan; Mahomoodally, Mohamad Fawzi; Lobine, Devina; Behl, Tapan; Zengin, Gökhan

doi:10.1016/j.indcrop.2020.112982

Cited by 7 publications

(12 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2-(4-(Methoxymethoxy)phenyl)-1-methyl-1H-indole-5-carbaldehyde (27a). A suspension of Pd(OAc) 2 , 1-iodo-4-(methoxymethoxy)benzene (26), 2-nitrobenzoic acid, Ag 2 O, and 1-methyl-1H-indole-5-carbaldehyde (23a) in anhydrous DMF under N 2 atmosphere was stirred at 25 • C for 24 h. Then, the reaction mixture was filtered through Celite ® using EtOAc as eluent and washed with NH 4 Cl (s.s., 5 mL), NaHCO 3 (s.s., 5 mL), and brine (5 mL). The organic phase was dried over Na 2 SO 4 and evaporated under reduced pressure.…”

Section: Methodsmentioning

confidence: 99%

“…Based on this rationale, we took inspiration from the core structure of lophirone E (1, Figure 1), characterized by both a polyoxygenated A ring and a heterocyclic 2-(4hydroxyphenyl)benzofuran B ring. This is a natural chalcone isolated from the stem barks of Lophira lanceolata [25], whose extracts present interesting antiparasitic and antiinflammatory properties [26,27]. As the first step of our study, we developed a synthetic strategy for the preparation of 1.…”

Section: Retrosynthetic Analysismentioning

confidence: 99%

“…The mode of action of synthetic and natural chalcones has not been elucidated yet, even though some targets, such as the arginase enzyme or enzymes involved in the trypanothione metabolic pathways [14][15][16], have been postulated. In addition, licochalcone A has been shown to alter the ultrastructure of the mitochondria and to inhibit the activity of fumarate reductase in the respiratory chain of L. major promastigote [17,18] Molecules 2022, 26…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Total Synthesis of the Natural Chalcone Lophirone E, Synthetic Studies toward Benzofuran and Indole-Based Analogues, and Investigation of Anti-Leishmanial Activity

et al. 2022

View full text Add to dashboard Cite

The potential of natural and synthetic chalcones as therapeutic leads against different pathological conditions has been investigated for several years, and this class of compounds emerged as a privileged chemotype due to its interesting anti-inflammatory, antimicrobial, antiviral, and anticancer properties. The objective of our study was to contribute to the investigation of this class of natural products as anti-leishmanial agents. We aimed at investigating the structure–activity relationships of the natural chalcone lophirone E, characterized by the presence of benzofuran B-ring, and analogues on anti-leishmania activity. Here we describe an effective synthetic strategy for the preparation of the natural chalcone lophirone E and its application to the synthesis of a small set of chalcones bearing different substitution patterns at both the A and heterocyclic B rings. The resulting compounds were investigated for their activity against Leishmania infantum promastigotes disclosing derivatives 1 and 28a,b as those endowed with the most interesting activities (IC50 = 15.3, 27.2, 15.9 μM, respectively). The synthetic approaches here described and the early SAR investigations highlighted the potential of this class of compounds as antiparasitic hits, making this study worthy of further investigation.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Retrosynthetic Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Total Synthesis of the Natural Chalcone Lophirone E, Synthetic Studies toward Benzofuran and Indole-Based Analogues, and Investigation of Anti-Leishmanial Activity

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The leaves contain lanceolatin A and B. [8][9] The meni oil, obtained from the fruit is used to treat dermatosis, toothache and muscular stress. [9] A decoction of the roots is taken orally by women to treat menstrual pain, intestinal ailments and malaria.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9] The meni oil, obtained from the fruit is used to treat dermatosis, toothache and muscular stress. [9] A decoction of the roots is taken orally by women to treat menstrual pain, intestinal ailments and malaria. [10] The bark is also used to treat gastro-intestinal problems and fevers.…”

Section: Introductionmentioning

confidence: 99%

Pharmacognostic Evaluations of Leaves and Rootback of Lophira lanceolata Tiegh. Ex Keay (False Shea)

Nefai¹,

Aliero²,

Fakka³

et al. 2022

View full text Add to dashboard Cite

Objectives: The present study sought to establish quality control parameters of a locally and ubiquitously occurring medicinal plant, Lophira lanceolata which is utilized as folk medicine among the local communities in Northern Nigeria as well as other regions, due to its therapeutic indication mainly as an aphrodisiac, among other uses. Materials and Methods: Pharmacognostically, different types of evaluations were carried out that focuses on organoleptic, macroscopic, microscopic, chemical evaluations as well as heavy metal assessments using Atomic Absorption Spectroscopy (AAS). Results: Organoleptic and macroscopic studies revealed some features of the leaves as green and oblanceolate, pinnate venation, with an average leaf size length and width of 14-15 and 4-5 cm respectively. The root has a light pale-brown outer surface and a reddish-brown inner surface. The outer surface was soft and dry while the inner surface was moist and smooth. Leaf microscopy indicated the presence of anisocytic or cruciferous type of stomata while both the rootbark and leaves are not devoid of common ergastic cell contents of calcium oxalate, lignin, starch, protein and tannin. Phytochemical evaluations revealed abundance of phytoconstituent that are richly phenolic of the types of saponin, tannin, triterpenoid, flavonoid, glycosides, diterpenoids, alkaloid, steroid, anthraquinones and phenols etc. Physicochemical evaluations showed a good source of mineral content of carbohydrate (35.93 ± 1.9199 for leaves and 33.58 ± 1.6791 for rootbark), Ash (9.33 ± 0.4714 for leaves and 7.17 ± 0.2358 for rootbark) in the plant. Heavy metal analysis of the leaves and rootbark investigated for Cadmium, Copper, Lead and Mercury showed that their concentrations were within the WHO (2002) permissible limits. Conclusion: This study provides the scientific data for the proper identification and establishment of standards for the use of the plant, Lophira lanceolata (False shea).

show abstract

Phytochemical profiling of Blumea laciniata (Roxb.) DC. and its phytopharmaceutical potential against diabetic, obesity, and Alzheimer’s

Swaraz¹,

Sultana²,

Bari

et al. 2021

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

Metabolite characterization, antioxidant, anti-proliferative and enzyme inhibitory activities of Lophira lanceolata Tiegh. ex Keay extracts

Cited by 7 publications

References 43 publications

Total Synthesis of the Natural Chalcone Lophirone E, Synthetic Studies toward Benzofuran and Indole-Based Analogues, and Investigation of Anti-Leishmanial Activity

Total Synthesis of the Natural Chalcone Lophirone E, Synthetic Studies toward Benzofuran and Indole-Based Analogues, and Investigation of Anti-Leishmanial Activity

Pharmacognostic Evaluations of Leaves and Rootback of Lophira lanceolata Tiegh. Ex Keay (False Shea)

Phytochemical profiling of Blumea laciniata (Roxb.) DC. and its phytopharmaceutical potential against diabetic, obesity, and Alzheimer’s

Contact Info

Product

Resources

About