Metabolomic estimation of the diagnosis of hepatocellular carcinoma based on ultrahigh performance liquid chromatography coupled with time-of-flight mass spectrometry

Abstract

Metabolomics has been shown to be an effective tool for biomarker screening and pathway characterization and disease diagnosis.

Untargeted metabolomics using liquid chromatography coupled with mass spectrometry for rapid discovery of metabolite biomarkers to reveal therapeutic effects ofPsoralea corylifoliaseeds against osteoporosis

“…Eleven of them have extremely signicant difference (p < 0.01), revealing that PCS may achieve the effect of treating glucocorticoid-induced osteoporosis by adjusting the metabolic level of these biomarkers. Metabolomics method has demonstrated potential in some elds such as toxicology, [49][50][51][52][53][54][55] nutrition, [56][57][58][59][60][61] genetic manipulation, [62][63][64][65][66][67] cancer, [68][69][70][71][72] diabetes, [73][74][75][76][77][78][79][80][81] environment, [82][83][84][85][86][87][88][89] disease diagnosis 90 and drug discovery and research. [91][92][93][94][95][96]…”

High-throughput untargeted metabolomics and chemometrics reveals pharmacological action and molecular mechanism of chuanxiong by ultra performance liquid chromatography combined with quadrupole-time-of-flight-mass spectrometry

“…[82][83][84][85] Mass spectrometry based chinmedomics could be used to discover lipid biomarkers [86][87][88] and exploring the effects and mechanism of chinese herb medicine. [89][90][91][92][93][94][95][96] In this study, another key lipid metabolism enzyme closely related to cancer is SCD1, a desaturase that generates MUFA from SFA. Suppressing SCD1 in LC cells can signicantly inhibit the proliferation, survival and invasion of cancer cells in vitro and the tumorigenicity in vivo, and this inhibitory ability may hinder cells from passing through G1/S cell cycle and induce programmed cell death through the reduction of MUFA, and have a vital function in the initiation of LC cells.…”

Comparative metabolomics unveils molecular changes and metabolic networks of syringin against hepatitis B mice by untargeted mass spectrometry

“…99 Currently, the detection of serum biomarkers can be used as an indicator to reect disease states. [100][101][102][103][104][105][106][107][108][109][110][111][112][113][114][115] Syringin can regulate the levels of proline, ornithine, and glutamate to the level of control group by affecting alanine, aspartate and glutamate metabolism, and arginine and proline metabolism.…”