Metabonomics study on the hepatoprotective effect of polysaccharides from different preparations of Angelica sinensis

The investigation of anti-inflammatory activity of volatile oil of Angelica sinensis by plasma metabolomics approach

“…Raw data were filtered and then subjected to retention time correction and peak alignment [8]. The data matrix was normalized to the sum of all peak areas of each sample, and then the missing value was eliminated via the 80% correction method.…”

“…Over 70 compounds have been isolated and identified from AS, including essential oil (such as ligustilide, butylphthalide and senkyunolide A), phthalide dimers, organic acids and their esters (such as ferulic acid), polysaccharides, vitamins, amino acids, and others [4,5]. In previous studies, we studied the hematopoietic function of AS [6] and the hepatoprotective effect of AS polysaccharides [7,8]. Inflammation is a common pathological phenomenon and various inflammatory diseases occupy an extremely important place in human and animal disease spectrum.…”

Metabolomics study on promoting blood circulation and ameliorating blood stasis: Investigating the mechanism of Angelica sinensis and its processed products

“…Studies have shown that proper processing of Chinese herbal medicines before clinical use can not only change their pharmacological activities and reduce their side effects, but also increase the curative effect (Singhuber, Zhu, Prinz, & Kopp, ; Zhao et al, ). Our previous studies showed that the blood‐enriching effect of JDG (Ji et al, ), the anti‐inflammatory effect of volatile oil from JDG or CDG and the hepatoprotective effect of polysaccharides from CDG were significantly enhanced (Hua, Xue, Zhang, Wei, & Ji, ; Zhong et al, ), which may be caused by changes in its chemical composition and content (Ji et al, ). At present, research on the herb pair Gui‐Hong and Danggui‐zhiqiao has shown a significant effect on promoting blood circulation and relieving blood stasis (Li et al, ; Wang, Li, et al, ).…”

Metabonomic analysis of the anti‐inflammatory effects of volatile oils of Angelica sinensis on rat model of acute inflammation

“…This approach coincides well with the integrity and systemic features of TCM. Therefore, metabolomics has been increasingly used as a versatile tool for assessing the effect of TCM and elucidating its molecular mechanism (Hua et al, ; Li et al, ). In order to explore the anti‐inflammatory mechanism of VOAS, a corresponding metabonomics study is required.…”