Metachronous bilateral renal cell carcinoma with an interval of more than 10 years

Abstract

Multiple second tumors may be suggestive of metastasis from the first tumor. The favorable outcome in this group reflects the gentle biological nature of these slow-growing tumors that had taken a long time to become clinically obvious. Because of the limited number of cases in this study, further investigation will be needed.

Bilateral Asynchronous Renal Cell Carcinoma with Metastatic Involvement of the Tongue

“…Overt metastasis is observed in 20–30% of patients at first presentation [5]. RCC is also known for late recurrence; lesions can appear 10 years or more after initial surgical treatment [6]. Intrarenal sites can be affected by late RCC recurrence, but involvement of contralateral or bilateral renal involvement is very unusual, especially after a long interval [6].…”

“…RCC is also known for late recurrence; lesions can appear 10 years or more after initial surgical treatment [6]. Intrarenal sites can be affected by late RCC recurrence, but involvement of contralateral or bilateral renal involvement is very unusual, especially after a long interval [6]. Bilateral renal involvement, without a hereditary component, is infrequent (3–5% of cases), but tends to be metachronous, occurring within 10 years of primary diagnosis and treatment.…”

“…Bilateral renal involvement, without a hereditary component, is infrequent (3–5% of cases), but tends to be metachronous, occurring within 10 years of primary diagnosis and treatment. Presence of undetectable micrometastasis at the time of original diagnosis may account for this [6]. …”

“…However, presence of multiple foci of RCC within the second kidney is suggestive of latent metastases rather than a new primary. The prognosis of latent, metachronous RCC is not significantly different to unilateral renal involvement, suggesting that despite a tendency for recurrence, these tumours grow slowly [6]. However, when lingual metastasis is present in the background of a latent metachronous lesion, prognosis is generally very poor because there is usually widely disseminated RCC.…”

Bilateral Asynchronous Renal Cell Carcinoma With Lung Metastases: A Case Report of a Patient Treated Solely With High-dose Intravenous and Subcutaneous Viscum album Extract for a Second Renal Lesion

“…RCC is also known for late recurrence; lesions can appear 10 years or more after the initial surgical treatment (41). A contralateral kidney tumor may be considered a late recurrence (asynchronous) but may also represent a de novo pathology.…”