Metagenomic analysis of gut microbiota alteration in a mouse model exposed to mycotoxin deoxynivalenol

Wang, Jun-Jie; Zhang, Ruiqian; Zhai, Qiu-Yue; Liu, Jing-Cai; Li, Na; Liu, Wen-Xiang; Li, Lan; Shen, Wei

doi:10.1016/j.taap.2019.04.009

Cited by 42 publications

(39 citation statements)

References 36 publications

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“…Cecal species’ richness and evenness were decreased upon DON exposure in broiler chickens and mice, Bacteroidetes and Firmicutes abundance increased, while Proteobacteria decreased, suggesting an overall impaired gut microbiota community [ 170 , 171 ]. A fecal microbiota analysis explored DON-induced gut microbiota changes in nude mice and pigs and showed that DON treatment generated a higher abundance of Clostridiales , Lachnospiraceae, and fecal aerobic mesophilic bacteria [ 140 , 172 ].…”

Section: Intestinal Dysfunction Induced By Mycotoxinsmentioning

confidence: 99%

The Compromised Intestinal Barrier Induced by Mycotoxins

Gao

Meng

Liu

et al. 2020

Toxins

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Mycotoxins are fungal metabolites that occur in human foods and animal feeds, potentially threatening human and animal health. The intestine is considered as the first barrier against these external contaminants, and it consists of interconnected physical, chemical, immunological, and microbial barriers. In this context, based on in vitro, ex vivo, and in vivo models, we summarize the literature for compromised intestinal barrier issues caused by various mycotoxins, and we reviewed events related to disrupted intestinal integrity (physical barrier), thinned mucus layer (chemical barrier), imbalanced inflammatory factors (immunological barrier), and dysfunctional bacterial homeostasis (microbial barrier). We also provide important information on deoxynivalenol, a leading mycotoxin implicated in intestinal dysfunction, and other adverse intestinal effects induced by other mycotoxins, including aflatoxins and ochratoxin A. In addition, intestinal perturbations caused by mycotoxins may also contribute to the development of mycotoxicosis, including human chronic intestinal inflammatory diseases. Therefore, we provide a clear understanding of compromised intestinal barrier induced by mycotoxins, with a view to potentially develop innovative strategies to prevent and treat mycotoxicosis. In addition, because of increased combinatorial interactions between mycotoxins, we explore the interactive effects of multiple mycotoxins in this review.

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Section: Intestinal Dysfunction Induced By Mycotoxinsmentioning

confidence: 99%

The Compromised Intestinal Barrier Induced by Mycotoxins

Gao

Meng

Liu

et al. 2020

Toxins

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“…LEfSe (LDA EffectSize) uses linear discriminant analysis (LDA) to estimate the impact of the abundance of each component, and to identify the communities or species that have significant difference effect on the division of samples. It emphasizes statistical significance and biological relevance [17]. According to species richness, the significant difference in intestinal microflora (seen Figure 8) was found in the following genera: Clostridium XlVb (A); Lactobacillus, Saccharibacteria_genera_incertae_sedis, Mucispirillum, Anaerotruncus; Intestinimonas (B); Alistipes, Barnesiella (C); Prevotella, Butyricimonas, Sutterella, Peptococcus (D).…”

Section: Difference Analysismentioning

confidence: 90%

“…It was concluded that the sequencing depth was sufficient to cover all bacterial species and enough to reflect the richness level, which also ensured that the data of sample sequencing in each group were reasonable. (2) Beta Diversity of Intestinal Flora [17] Beta diversity analysis was used to compare differences in species diversity of a pair of inter-group samples. UniFrac uses phylogenetic information to compare species diversity among samples.…”

Section: Dilution Curves Of Microorganisms In Samplesmentioning

confidence: 99%

“…The UniFrac results are divided into weighted UniFrac and Unweighted UniFrac: the weighted results consider the abundance of the sequence, but the unweighted results do not consider the abundance of the sequence. The samples were clustered according to the statistical results of the differences among the samples, and the distance between the samples was calculated to judge the similarity of the species composition among the samples [17].…”

Section: Beta Diversity Of Intestinal Floramentioning

confidence: 99%

“…The abscissa represents the first principal coordinate, and the percentage in parentheses represents the contribution rate of the first principal coordinate to the sample difference; the ordinate represents the second principal coordinate, and the percentage in parentheses represents the contribution rate of the second principal coordinate to the sample difference.2.2.3. Difference Analysis[17].LEfSe (LDA EffectSize) uses linear discriminant analysis (LDA) to estimate the impact of the abundance of each component, and to identify the communities or species that have significant difference effect on the division of samples. It emphasizes statistical significance and biological relevance.…”

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confidence: 99%

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Dietary Recombinant Phycoerythrin Modulates the Gut Microbiota of H22 Tumor-Bearing Mice

Liu

et al. 2019

Marine Drugs

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Normal intestinal flora is widely involved in many functions of the host: nutritional metabolism; maintenance of intestinal microecological balance; regulation of intestinal endocrine function and nerve signal transduction; promotion of intestinal immune system development and maturation; inhibition of pathogenic bacteria growth and colonization, reduction of its invasion to intestinal mucosa, and so on. In recent years, more and more studies have shown that intestinal flora is closely related to the occurrence, development, and treatment of various tumors. It is indicated that recombinant phycoerythrin (RPE) has significant anti-tumor and immunomodulatory effects. However, little is known about the mechanism of the effect of oral (or intragastric) administration of RPE on gut microbiota in tumor-bearing animals. In this study, using high-throughput 16S rDNA sequencing, we examined the response of gut microbiota in H22-bearing mice to dietary RPE supplementation. The results showed that the abundance of beneficial bacteria in the mice intestinal flora decreased and that of the detrimental flora increased after inoculation with tumor cells (H22); following treatment with dietary RPE, the abundance of beneficial bacteria in the intestinal flora significantly increased and that of detrimental bacteria decreased. In this study, for the first time, it was demonstrated that dietary RPE could modulate the gut microbiota of the H22 bearing mice by increasing the abundance of beneficial bacteria and decreasing that of detrimental bacteria among intestinal bacteria, providing evidence for the mechanism by which bioactive proteins affect intestinal nutrition and disease resistance in animals.

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Effects of Sporisorium reiliana polysaccharides and Phoenix dactylifera monosaccharides on the gut microbiota and serum metabolism in mice with fructose-induced hyperuricemia

Wang

Zhang

et al. 2022

Arch Microbiol

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Metagenomic analysis of gut microbiota alteration in a mouse model exposed to mycotoxin deoxynivalenol

Cited by 42 publications

References 36 publications

The Compromised Intestinal Barrier Induced by Mycotoxins

The Compromised Intestinal Barrier Induced by Mycotoxins

Dietary Recombinant Phycoerythrin Modulates the Gut Microbiota of H22 Tumor-Bearing Mice

Effects of Sporisorium reiliana polysaccharides and Phoenix dactylifera monosaccharides on the gut microbiota and serum metabolism in mice with fructose-induced hyperuricemia

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