“…Nanoparticles [14,15], nanotubes [16,17], nanowires [17,18,19,20,21,22,23] and fiber-optics as the matrices of DNA biosensors to detect DNA specific sequence and DNA hybridization have been reported. Fiber opticbased DNA biosensors have many advantages over other matrices-based DNA biosensors as following: 1) Fibers have a flexible geometry and can be tractably miniaturized at low cost to nanosacle structure for in vivo measurements.…”