Metal-catalyzed Furan Synthesis. A Review

Dihydronaphthofurans: synthetic strategies and applications

“…The rst synthesis of 1,2-dihydronaphtho[2,1-b]furan has been reported by Mckusick in 1948. Sodium methoxide and potassium iodide promoted condensation of 2-naphthol with bmethyl allyl chloride in methanol at room temperature for several days afforded b-methylallyl-2-naphthyl ether (1). Claisen rearrangement of 1 led to the formation of intermediate 2.…”

“…The synthesis of this fundamental structural building block has received signicant attention and a wide variety of approaches are available to the synthetic practitioner. 1 Arene ring-fused furan derivatives such as dihydronaphthofurans (DHNs) have attracted widespread interest in view of their presence in many important natural and non-natural products. Natural products with DHN moieties have been shown to have a wide range of biological and pharmacological properties.…”

Recent Organic Transformations with Silver Carbonate as a Key External Base and Oxidant

“…In 2012, Lei and co-workers reported the direct C-H functionalization and oxidative coupling of two C-H bonds as an ideal synthetic strategy for accessing highly substituted furans (Scheme 2) [14]. Although synthetic methods for preparing substituted furans have been reported previously [15], new synthetic strategies are required to achieve selective cross coupling of two more hydrocarbons. The homocoupling of terminal alkynes occurs easily under most oxidative conditions [16].…”

Metal-Catalyzed Routes for the Synthesis of Furocoumarins and Coumestans

“…Transition-metal-catalyzed transformations are probably the most powerful tools presently available for preparing furans from readily accessible starting materials [47][48][49][50][51][52][53][54][55][56]. Accordingly, the development of efficient synthetic routes to produce furans has been a major research field for over a century.…”