Metal complexes of ONO donor Schiff base ligand as a new class of bioactive compounds; Synthesis, characterization and biological evolution

Naik, Krishna; Selvaraj, S.; Naik, Nagaraja

doi:10.1016/j.saa.2014.03.038

Cited by 41 publications

(12 citation statements)

References 30 publications

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“…C 33 was more active against E. coil (MIC=4.2 × 10 −2 M) than standared drug chloramphenicol (MIC=5.9 × 10 −2 M). similarly, the antifungal activity of C 33 was much better against A. niger, A. flavus and R. bataicola than ligand and standared nystatin . C 34 of the general formula [Mn( L 34 ) 2 ].2H 2 O was synthesized by the reaction of manganese chloride and ligand L 34 , 2‐Aminobenzimidazole‐5‐Bromosalicylaldehyde.…”

Section: Mn–complexes With Tridentate Ligandsmentioning

confidence: 99%

Coordination Complexes of Manganese and Their Biomedical Applications

Ali

Iqbal

2017

ChemistrySelect

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The clinical success of metallodrugs is rapidly increasing. The historical use of cisplatin and recently a successful marketing of its clinically advanced derivatives (oxaliplatin, carboplatin, nedaplatin, lobaplatin and heptaplatin) for the treatment of various types of cancer has opened new horizons for metal based drugs. Complexes of cobalt, gold, ruthenium, palladium, manganese and even arsenic are either being marketed or close to get success in clinical trials for the treatment of various diseases. Current review compiles the advances on manganese complexes and their biomedical applications. A possible structure activity relationship has been discussed.

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Section: Mn–complexes With Tridentate Ligandsmentioning

confidence: 99%

Coordination Complexes of Manganese and Their Biomedical Applications

Ali

Iqbal

2017

ChemistrySelect

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“…This value is of particular importance since it was highly dependent on the geometry of the molecule. It is known that the transition from a square planar structure to a deformed tetrahedral structure leads to a red shift of absorption in the electronic spectrum . Thus, the complexes 1 and 2 , are not perfectly square planar and the broad as well as low energy bands obtained at longer wavelengths are attributed to the deformed tetrahedral structure.…”

Section: Resultsmentioning

confidence: 99%

New anthracene based Schiff base ligands appended Cu(II) complexes: Theoretical study, DNA binding and cleavage activities

Gubendran

Kumar²,

Kesavan³

et al. 2017

Applied Organom Chemis

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New anthracene based Schiff base ligands L1 and H(L2), their Cu(II) complexes [Cu(L1)Cl2] (1) and [Cu(L2)Cl] (2), (where L1 = N1,N2‐bis(anthracene‐9‐methylene)benzene‐1,2‐diamine, L2 = (2Z,4E)‐4‐(2‐(anthracen‐9‐ylmethyleneamino)phenylimino)pent‐2‐en‐2‐ol) have been prepared and characterized by elemental analysis, NMR, FAB‐mass, EPR, FT‐IR, UV–Vis and cyclic voltammetry. The electronic structures and geometrical parameters of complexes 1 and 2 were analyzed by the theoretical B3LYP/DFT method. The interaction of these complexes 1 and 2 with CT‐DNA has been explored by using absorption, cyclic voltammetric and CD spectral studies. From the electronic absorption spectral studies, it was found that the DNA binding constants of complexes 1 and 2 are 8.7 × 103 and 7.0 × 104 M−1, respectively. From electrochemical studies, the ratio of DNA binding constants K+/K2+ for 2 has been estimated to be >1. The high binding constant values, K+/K2+ ratios more than unity and positive shift of voltammetric E1/2 value on titration with DNA for complex 2 suggest that they bind more avidly with DNA than complex 1. The inability to affect the conformational changes of DNA in the CD spectrum is the definite evidences of electrostatic binding by the complex 1. It can be assumed that it is the bulky anthracene unit which sterically inhibits these complexes 1 and 2 from intercalation and thereby remains in the groove or electrostatic. The complex 2 hardly cleaves supercoiled pUC18 plasmid DNA in the presence of hydrogen peroxide. The results suggest that complex 2 bind to DNA through minor groove binding.

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“…New bands are found in the spectra of the complexes in the regions 560–595 cm −1 (phenolic O), which are assigned to ʋ(M–O) stretching vibrations. The bands at 445–480 cm −1 in metal complexes have been assigned to ʋ(M–N) of the azomethine mode . The appearance of these new bands also support the involvement of oxygen and nitrogen in coordination.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, spectral and antibacterial activity of Co(II), Ni(II) and Zn(II) complexes with 2‐hydroxy‐benzoic acid(3,4‐dihydro‐2H‐naphthalen‐1‐ylidene)‐hydrazide

Tyagi

Chandra

2017

Applied Organom Chemis

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A bioactive Schiff base HL i.e. 2-hydroxy-benzoic acid(3,4-dihydro-2Hnaphthalen-1-ylidene)-hydrazide was synthesized by reacting equimolar amount of salicylic acid hydrazide and 1-tetralone. Co(II), Ni(II) and Zn(II) complexes of ligand HL was synthesized in 1:1 and 1:2 molar ratio of metal to ligand. The structure of the synthesized ligand and metal complexes was established by elemental analysis, molar conductance, magnetic susceptibility measurements, electronic, IR and EPR spectral techniques. For determining the thermal stability the TGA has been done. In DFT studies the geometries of Schiff bases and metal complexes were fully optimized with respect to the energy using the 6-31 + g(d,p) basis set. Spectral data reveal that ligand behave uninegative tridentate in ML complexes and uninegative bidentate in ML 2 complexes. On the basis of characterization octahedral geometry has been assigned for Co(II) and Ni(II) complexes, while tetrahedral for Zn(II) complexes. Antibacterial activity of the synthesized compounds were evaluated against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Xanthomonas campestris and Pseudomonas aeruginosa and the results revealed that metal complexes show enhanced activity in comparison to free ligand.

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Metal complexes of ONO donor Schiff base ligand as a new class of bioactive compounds; Synthesis, characterization and biological evolution

Cited by 41 publications

References 30 publications

Coordination Complexes of Manganese and Their Biomedical Applications

Coordination Complexes of Manganese and Their Biomedical Applications

New anthracene based Schiff base ligands appended Cu(II) complexes: Theoretical study, DNA binding and cleavage activities

Synthesis, spectral and antibacterial activity of Co(II), Ni(II) and Zn(II) complexes with 2‐hydroxy‐benzoic acid(3,4‐dihydro‐2H‐naphthalen‐1‐ylidene)‐hydrazide

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