Metal–organic frameworks: a future toolbox for biomedicine?

Mendes, Ricardo F.; Figueira, Flávio; Leite, José P.; Gales, Luı́s; Paz, Filipe A. Almeida

doi:10.1039/d0cs00883d

Cited by 171 publications

(88 citation statements)

References 173 publications

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“…Besides the emerging applications in PEFCs (involving HOR, ORR, alcohol oxidation reactions) and WECs (comprising OER, HER, overall water splitting) as featured in this review article, the surface overcoating strategy also shows increasing potential for fabricating advanced nanomaterials, which are already applied in thermal-catalytic reactions, 188,[424][425][426][427][428] redox flow batteries, 429,430 metal-air batteries, 431,432 solid oxide fuel cells, [433][434][435] lithium-ion batteries or capacitors, 69,436,437 ammonia electrosynthesis, 438,439 CO 2 electrocatalytic reduction, [440][441][442] and biotechnology. 443,444 One could obtain highly dispersed fine metal nanoparticles with the aid of organic or inorganic overlayers after annealing treatment. As appealing in the thermal catalysis field, the carbon nanoshell derived from organic capping agents or polymers has been employed as a sacrificial protector to inhibit metal particles from migration/coalescence and sintering.…”

Section: Discussionmentioning

confidence: 99%

Catalyst overcoating engineering towards high-performance electrocatalysis

2022

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Section: Discussionmentioning

confidence: 99%

Catalyst overcoating engineering towards high-performance electrocatalysis

2022

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“…Fifth, the applications of MOFs with unconventional phases can be further explored. Besides luminescence, adsorption, and catalysis, MOFs with unconventional phases may also exhibit enhanced performances in other emerging applications of MOFs, such as biomedicine, [ 113 ] mechanical applications, [ 114 ] and sensors [ 115 ] . Sixth, the concept of PEN can be extended to MOF‐based hybrid materials.…”

Section: Discussionmentioning

confidence: 99%

Phase engineering of metal‐organic frameworks

Zheng

Wang

et al. 2021

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As an important category of porous crystalline materials, metal‐organic frameworks (MOFs) have attracted extensive research interests owing to their unique structural features such as tunable pore structure and enormous surface area. Besides controlling the size, dimensionality, and composition of MOFs, further exploring the crystal‐phase‐dependent physicochemical properties is essential to improve their performances in various applications. Recently, great progress has been achieved in the phase engineering of nanomaterials (PEN), which provides an effective strategy to tune the functional properties of nanomaterials by modulating the arrangement of atoms. In this review, we adopt “phase” instead of “topology” to describe the crystal structure of MOFs and summarize the recent advances in phase engineering of MOFs. The two main strategies used to control the phase of MOFs, that is, phase‐controlled synthesis and phase transformation of MOFs, will be highlighted. The roles of various reaction parameters in controlling the crystal phase of MOFs are discussed. Then, the phase dependence of MOFs in various applications including luminescence, adsorption, and catalysis are introduced. Finally, some personal perspectives about the challenges and opportunities in this emerging field are presented.

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“…[25,26] For biomedical research, MOFs have also been accepted as the perfect drug carriers due to their excellent antibacterial property, great biocompatibility, controllable drug release, and high drug loading. [27][28][29][30] Especially, the aperture and surface properties of MOFs can be tuned by refining the metal sites and organic linkers, which has attracted extensive attention to develop versatile systems for delivering different kinds of drugs. [31][32][33] Although with much progress, the applications of this superior material in facilitating wound healing are rarely reported, and the combinations of MOFs and MNs are also seldom explored.…”

Section: Introductionmentioning

confidence: 99%

Zn‐MOF Encapsulated Antibacterial and Degradable Microneedles Array for Promoting Wound Healing

Yao

Chi

Wang

et al. 2021

Adv Healthcare Materials

171

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An infected skin wound caused by external injury remains a serious challenge in clinical practice. Wound dressings with the properties of antibacterial activity and potent regeneration capacity are highly desirable for wound healing. In this paper, a degradable, ductile, and wound-friendly Zn-MOF encapsulated methacrylated hyaluronic acid (MeHA) microneedles (MNs) array is fabricated through the molding method for promoting wound healing. Due to the damage capability against the bacteria capsule and oxidative stress of the zinc ion released from the Zn-MOF, such MNs array presents excellent antibacterial activity, as well as considerable biocompatibility. Besides, the degradable MNs array composed of photo-crosslinked MeHA possesses the superior capabilities to continuously and steadily release the loaded active ingredients and avoid secondary damage to the wound. Moreover, the low molecular weight hyaluronic acid (HA) generated by hydrolysis of MeHA is also conducive to tissue regeneration. Benefiting from these features, it has been demonstrated that the Zn-MOF encapsulated degradable MNs array can dramatically accelerate epithelial regeneration and neovascularization. These results indicate that the combination of MOFs and degradable MNs array is of great value for promoting wound healing.

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Metal–organic frameworks: a future toolbox for biomedicine?

Abstract: The present review focuses on the use of Metal–Organic Frameworks, (MOFs) highlighting the most recent developments in the biological field and as bio-sensors.

Cited by 171 publications

References 173 publications

Catalyst overcoating engineering towards high-performance electrocatalysis

Catalyst overcoating engineering towards high-performance electrocatalysis

Phase engineering of metal‐organic frameworks

Zn‐MOF Encapsulated Antibacterial and Degradable Microneedles Array for Promoting Wound Healing

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