Metal oxide nanocarrier for targeted drug delivery towards the treatment of global infectious diseases: A review

Saha, Shuvo; Khaleque, Abdul; Bacchu, M.S.; Aly, Mohamed Aly Saad; Ali, M.R.

doi:10.1016/j.jddst.2023.104728

Cited by 17 publications

(2 citation statements)

References 131 publications

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“…Benefiting from its considerable surface area, compact size, robust stability, and cost-effectiveness, TiO 2 stands out as an exemplary selection for nanocarriers in drug delivery systems. The integration of TiO 2 nanocarriers streamlines drug administration at diminished doses, leading to a prolonged presence within the vascular system and intensifying their therapeutic efficacy ( Saha et al, 2023 ). A drug delivery system employing biocompatible nanoparticles was developed by encapsulating ciprofloxacin within TiO 2 nanocomposites.…”

Section: Metal/metal-oxide Nanocompositesmentioning

confidence: 99%

Exploring nanocomposites for controlling infectious microorganisms: charting the path forward in antimicrobial strategies

Saravanan,

Subramani,

Rajaramon

et al. 2023

Front. Pharmacol.

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Nanocomposites, formed by combining a matrix (commonly polymer or ceramic) with nanofillers (nano-sized inclusions like nanoparticles or nanofibers), possess distinct attributes attributed to their composition. Their unique physicochemical properties and interaction capabilities with microbial cells position them as a promising avenue for infectious disease treatment. The escalating prevalence of multi-drug resistant bacteria intensifies the need for alternative solutions. Traditional approaches involve antimicrobial agents like antibiotics, antivirals, and antifungals, targeting specific microbial aspects. This review presents a comprehensive overview of diverse nanocomposite types and highlights the potential of tailored matrix and antibacterial agent selection within nanocomposites to enhance treatment efficacy and decrease antibiotic resistance risks. Challenges such as toxicity, safety, and scalability in clinical applications are also acknowledged. Ultimately, the convergence of nanotechnology and infectious disease research offers the prospect of enhanced therapeutic strategies, envisioning a future wherein advanced materials revolutionize the landscape of medical treatment.

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Section: Metal/metal-oxide Nanocompositesmentioning

confidence: 99%

Exploring nanocomposites for controlling infectious microorganisms: charting the path forward in antimicrobial strategies

Saravanan,

Subramani,

Rajaramon

et al. 2023

Front. Pharmacol.

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“…Nanoparticles are defined as particles of size < 100 nm [ 24 ], and nanoparticles of metals can be expected to score high on the parameter of bioavailability compared to larger particles of the same metal [ 25 ]. The potential of metal oxide nanocarriers for targeted drug delivery toward the treatment of infectious diseases and as biomedical materials has been nicely reviewed by Saha et al [ 26 ] and Nikolova and Chavali [ 27 ], respectively. Due to their small size and larger surface area, nanoparticles show enhanced colloidal stability and, therefore, increased bioavailability.…”

Section: Introductionmentioning

confidence: 99%

Silversol® (a Colloidal Nanosilver Formulation) Inhibits Growth of Antibiotic-Resistant Staphylococcus aureus by Disrupting Its Physiology in Multiple Ways

Thakkar,

Gajera,

Mehta

et al. 2024

Pharmaceutics

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Antibiotic-resistant strains of Staphylococcus aureus are being viewed as a serious threat by various public health agencies. Identifying novel targets in this important pathogen is crucial to the development of new effective antibacterial formulations. We investigated the antibacterial effect of a colloidal nanosilver formulation, Silversol®, against an antibiotic-resistant strain of S. aureus using appropriate in vitro assays. Moreover, we deciphered the molecular mechanisms underlying this formulation’s anti-S. aureus activity using whole transcriptome analysis. Lower concentrations of the test formulation exerted a bacteriostatic effect against this pathogen, and higher concentrations exerted a bactericidal effect. Silversol® at sub-lethal concentration was found to disturb multiple physiological traits of S. aureus such as growth, antibiotic susceptibility, membrane permeability, efflux, protein synthesis and export, biofilm and exopolysaccharide production, etc. Transcriptome data revealed that the genes coding for transcriptional regulators, efflux machinery, transferases, β-lactam resistance, oxidoreductases, metal homeostasis, virulence factors, and arginine biosynthesis are expressed differently under the influence of the test formulation. Genes (argG and argH) involved in arginine biosynthesis emerged among the major targets of Silversol®’s antibacterial activity against S. aureus.

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Role of Exosomes in Parkinson’s and Alzheimer’s Diseases

Sharma,

Tyagi,

Chandra

et al. 2024

Exosomes Based Drug Delivery Strategies for Brain Disorders

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Metal oxide nanocarrier for targeted drug delivery towards the treatment of global infectious diseases: A review

Cited by 17 publications

References 131 publications

Exploring nanocomposites for controlling infectious microorganisms: charting the path forward in antimicrobial strategies

Exploring nanocomposites for controlling infectious microorganisms: charting the path forward in antimicrobial strategies

Silversol® (a Colloidal Nanosilver Formulation) Inhibits Growth of Antibiotic-Resistant Staphylococcus aureus by Disrupting Its Physiology in Multiple Ways

Role of Exosomes in Parkinson’s and Alzheimer’s Diseases

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