Metallic nanoparticles: technology overview & drug delivery applications in oncology

Abstract

The development of metallic nanoparticles is rapid and multidirectional, and the improved practical potential of metallic nanoparticle highlights their potency as new tools for future cancer therapeutics modalities.

Inulin-based polymer coated SPIONs as potential drug delivery systems for targeted cancer therapy

“…The crude product was purified by flash chromatography with light petroleum, then light petroleum/diethyl ether, 95:5 as eluent, to give 578 mg of 1,1′,2-tris-norsqualene acid (35% yield), as a colorless oil. 1 2.4. Synthesis of = inulin-1,1′,2-tris-nor-squalene-PEG2000 (INU-Sq-PEG2000) graft copolymer PEG-CHO (21 mg, 1.05 × 10 −2 mmol) was added to 4 mL of INU-Sq aqueous solution (22.5 mg/mL) at pH 6.8.…”

“…Yield 85% with respect to the starting inulin. The obtained graft copolymer was characterized by 1 To an aqueous suspension of Fe3O4 (5 mg/mL) INU-Sq-PEG2000 copolymer (50 mg) was added with gentile stirring. The obtained mixture was sonicated in an ultrasonic bath for 10 min, thus diluted to 5 mL with double distilled water and, finally, placed into dialysis tube (Spectra Por, Float-A-Lyzers) with a nominal molecular weight cut-off (NMWCO) 8-10 kDa.…”

“…Therapeutic approaches used to eradicate tumors involve invasive processes, long term largely ineffective, such as surgical removal of neoplastic mass [1]. The surgical therapy often needs further treatments during the follow-up, encompassing chemotherapy or radiotherapy [2].…”

“…The use of nanocarriers, designed to enhance drugs efficiency, permits to overcome some of these matters being drugs released into a specific body district. Several systems have been developed so as to act as drug delivery systems useful for targeted therapy, such as polymeric micelles [6], [7] and [8] liposomes [9], polymersomes [10], polymeric nanoparticles [11] and [12], and magnetic nanoparticles [1]. Magnetic nanoparticles represent an innovative class of nanocarrier which has proved capable of targeting anticancer drugs, avoiding the most part of limitations attributable to conventional therapeutic tools.…”

Applications of nanoparticles in cancer medicine and beyond: optical and multimodalin vivoimaging, tissue targeting and drug delivery

“…Based on these properties, several investigators, including our group, have considered SiNPs for applications as sensors [7], drug delivery systems [8] and/or bioimaging probes [9][10][11][12]. Metallic (iron oxide, gold, silver) NPs have been used for a huge number of applications in various areas of medical treatment and are emerging as tool for imaging, diagnosis, and for the delivery of therapeutic agents to tumor cells [13][14][15]. Metallic NPs can be used in diagnosis and therapy due to their unique properties of small size, large surface area to volume ratio, tunable absorption, photostability and cellular uptake [15].…”