Metaplastic breast carcinoma with osseous differentiation: A rare case report

Salih, Abdulwahid M.; Kakamad, Fahmi H.; Saeed, Yadkar A.; Muhialdeen, Aso S.

doi:10.1016/j.ijscr.2017.03.022

Cited by 6 publications

(8 citation statements)

References 10 publications

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“…6 MBCs are known to exhibit macroscopic calcification on mammogram and color doppler can manifest a blood-rich lesion; both characteristics were present in the present case. 1,4 Microscopically, the mesenchymal components include chondroid, osseous, rhabdomyoid, and sometimes neuroglial elements. The osseous component is a scarce form, accounting for only 0.2% of all breast carcinomas.…”

Section: Discussionmentioning

confidence: 99%

“…The osseous component is a scarce form, accounting for only 0.2% of all breast carcinomas. 1,4 Inadequate sampling can lead to misdiagnosis on core needle biopsy and fine-needle aspiration cytology. 7 The sarcomatous component of MBCs can resemble other spindle cell neoplasms like malignant phyllodes, fibrosarcoma, myoepithelial carcinoma, malignant fibrous histiocytoma, etc.…”

Section: Discussionmentioning

confidence: 99%

“…3 Osseous differentiation in metaplastic carcinoma is very rare. 4 Herein, we report a case of metaplastic breast carcinoma with osseous differentiation.…”

Section: Introductionmentioning

confidence: 95%

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Metaplastic breast carcinoma with extensive osseous differentiation

et al. 2021

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Metaplastic breast carcinoma is a rare subtype of invasive breast carcinoma. Metaplastic carcinoma with osseous differentiation is exceptionally uncommon. Because of the heterogenous microscopy of the lesion, various clinical and radiological features are observed, leading to diagnostic difficulty. Herein, we present a case of a 43-year-old female with a recurrent breast lump, who was clinically diagnosed as a phyllodes tumor. However, histopathological examination revealed metaplastic carcinoma with extensive osseous differentiation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Metaplastic breast carcinoma with extensive osseous differentiation

et al. 2021

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“…Metaplastic spindle cell and squamous cell carcinomas may present in a pure form without any recognizable ductular component. MBC with osseous differentiation is the rarest subtype, 2,3 usually triple negative. Thus, the tumors tend to have a poor prognosis 1 .…”

Section: Introductionmentioning

confidence: 99%

A unique presentation of metaplastic breast carcinoma, NOS: A case report

Mremi,

Mwakyembe,

Suleman

et al. 2023

Clinical Case Reports

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Key Clinical MessageA rare form of invasive breast carcinoma, NOS, also known as matrix‐producing carcinoma made up of epithelial and mesenchymal components. Usually, they are triple negative and clinically aggressive and respond poorly to neoadjuvant systemic therapy.AbstractMetaplastic breast carcinomas (MBCs) are ductal carcinomas that undergo metaplasia to form nonglandular growth patterns. They are extremely rare, constituting less than 1% of all invasive breast carcinomas. Matrix‐producing carcinoma is an exceedingly rare form of MBC distinguished by a ductal carcinomatous component with direct transition to areas of cartilaginous or osseous differentiation without the presence of an intervening spindle cell element. MBCs are clinically aggressive, but matrix‐producing subtypes have a relatively better prognosis. The tumors are usually triple negative. Therefore, surgery and chemotherapy are the main therapeutic approaches. Our report describes this unique form of MBC with prominent osseous differentiation in a 33‐year‐old female patient. Its distinct histological features and peculiar clinical behavior necessitate a thorough understanding of this one‐of‐a‐kind disease entity.

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“…Metaplastic breast carcinoma (MBC) is a heterogeneous group of indolent to highly aggressive tumors that consists of epithelial and non-glandular elements such as matrix-production, spindle cell morphology, squamous differentiation, or heterologous differentiation (ie, osseous or chondroid) [3] . Of the breast carcinoma subtypes, MBC accounts for less than 1%-5% of all cases of invasive breast cancer [4 , 5] .…”

Section: Introductionmentioning

confidence: 99%

Metaplastic carcinoma with osteosarcomatous differentiation in the breast: Case report

Asare,

White,

Rossi

2023

Radiology Case Reports

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Metaplastic breast carcinoma with osseous differentiation: A rare case report

Abstract: HighlightsMetaplastic breast carcinoma is a rare type of breast cancer.Osseous differentiation is a very rare subtype.We report a case of metaplastic breast carcinoma with osseous differentiation.

Cited by 6 publications

References 10 publications

Metaplastic breast carcinoma with extensive osseous differentiation

Metaplastic breast carcinoma with extensive osseous differentiation

A unique presentation of metaplastic breast carcinoma, NOS: A case report

Metaplastic carcinoma with osteosarcomatous differentiation in the breast: Case report

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