Metastases from Neuroendocrine Tumors to the Breast Are More Common than Previously Thought. A Diagnostic Pitfall?

Crona, Joakim; Granberg, Dan; Norlén, Olov; Wärnberg, Fredrik; Stålberg, Peter; Hellman, Per; Björklund, Peyman

doi:10.1007/s00268-013-2037-2

Cited by 14 publications

(17 citation statements)

References 48 publications

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“…Previous study showed that the first recurrent site was distant in 78% of patients and patients with distant recurrence had a shorter postrecurrent survival than those with local recurrence (6). There are only few reports that have demonstrated breast metastases of primary lung neuroendocrine tumors (7)(8)(9)(10). Here, we report a case of a female patient who developed metachronous bilateral breast metastases of a lung neuroendocrine tumor.…”

Section: Introductionmentioning

confidence: 75%

Metachronous bilateral breast metastases of a lung neuroendocrine tumor: A case report

et al. 2020

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Breast metastases of primary lung neuroendocrine tumors are rarely reported. The current report presents the case of a 41-year old female with no history of smoking who initially underwent surgery for a breast fibroadenoma, during which a neuroendocrine tumor of the right lung was detected via chest X-ray. The patient underwent surgery for the tumor and developed right breast nodules after adjuvant chemotherapy. Histological and immunohistochemical examinations of biopsies from these nodules indicated breast metastasis of the primary lung neuroendocrine tumor. The patient underwent mastectomy of the right breast but subsequently developed metastases in the left breast, for which local radiotherapy was administered. The observed metachronous bilateral breast metastases indicated that the contralateral breast should be considered during an investigation of metastasis.

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Section: Introductionmentioning

confidence: 75%

Metachronous bilateral breast metastases of a lung neuroendocrine tumor: A case report

et al. 2020

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“…Breast metastases from NENs are not common, although there is an increased frequency reported over the last years. This could be the result of more NEN breast metastases being correctly diagnosed, as specialists are more conscious that these lesions can resemble primary carcinomas and modern technology imaging aids in reaching the correct diagnosis [5,18,19,51]. In particular, an increased occurrence of breast metastases from GEP NENs has been reported [58].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, it has been shown that histological analysis and morphological evaluation with the use of auxiliary immunohistochemical studies are important in reaching a correct diagnosis, particularly in difficult cases such as those with an unknown primary [32,36]. Morphological distinction is often difficult on both FNA and lumpectomy specimens due to several overlapping features and the reported frequency of neuroendocrine cells (-25%) in breast carcinoma [13,[64][65][66][67][68].…”

Section: Discussionmentioning

confidence: 99%

“…The first case of a NEN metastasis excised from the breast of a 72-year-old woman was described by Chodoff [17]. Although recent data suggests that breast secondaries from NENs maybe more frequent than what was thought, based on the idea that many of them have been misdiagnosed in the past as primary NENs or carcinomas [4,18,19], they remain a rare phenomenon with no more than 200 cases published in the English literature to date [4,.…”

Section: Introductionmentioning

confidence: 99%

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The rare entity of bilateral and unilateral neuroendocrine metastases to the breast: a case series and literature review

Zagami

Kandaraki

Renne

et al. 2020

ecancer

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Introduction Primary neuroendocrine neoplasms (NENs) in the breast are very rare. Until 2011, the prevalence was 0.1% of all breast lesions and 1% of all NENs, whereas metastatic breast NENs represent 1%–2% of all breast tumours. However, it seems that over the last 5 years the diagnostic frequency of breast NENs has increased, probably for more alert specialists and advanced diagnostic tools, leading to a prevalence of 2%–5% of diagnosed breast cancers, mostly in the elderly population. Breast metastases from extramammary malignancies are uncommon and bilateral ones are even more uncommon, with few reported in the literature. We describe four clinical settings of breast metastases from different NENs and the multidisciplinary approach for diagnosis and treatment. Methods Four patients were found to have NEN primaries metastasised to the breast. A literature review was conducted to identify similar cases and characterise breast metastases from neuroendocrinal tumors (NETs). Results Two patients presented with bilateral breast metastases (one with well-differentiated panNET and another with atypical lung carcinoid) and two had unilateral (one with moderately differentiated lung NET and one with atypical lung carcinoid). There are about 13 cases of NEN breast metastases reported in the English literature. The ileum is the most common primary site, followed by the appendix, duodenum, pancreas and lung. Conclusion Breast lesions from extramammary primary often pose a diagnostic challenge, since a breast nodule can be the first and often the only presentation of the disease. However, differentiating between primary and secondary NEN breast lesions is essential, owing to different clinical management and prognosis.

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“…Babu et al [ 7 ] described two cases of lung neuroendocrine carcinomas who presented with breast lumps. Finally, Crona et al [ 15 ] reported 8 women with lung neuroendocrine tumors (either carcinoids or large cell neuroendocrine tumors) that developed breast metastases several months after diagnosis in the majority of cases.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Breast Metastasis from Neuroendocrine Carcinoma of the Lung: A Case Report and Review of the Literature

et al. 2020

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Breast metastasis originating from non-mammary tumors is an uncommon event accounting for 0.5–6.6% of all breast neoplasms. The primary malignancies that reportedly metastasize to the breast most frequently are hematologic malignancies, such as leukemia and lymphoma and malignant melanoma. Breast cancer metastasis resulting from a primary lung neoplasm is significantly less commonly described in the literature. Herein, we present the unusual case of a patient with metastatic disease to the breast from a primary lung tumor.

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Metastases from Neuroendocrine Tumors to the Breast Are More Common than Previously Thought. A Diagnostic Pitfall?

Cited by 14 publications

References 48 publications

Metachronous bilateral breast metastases of a lung neuroendocrine tumor: A case report

Metachronous bilateral breast metastases of a lung neuroendocrine tumor: A case report

The rare entity of bilateral and unilateral neuroendocrine metastases to the breast: a case series and literature review

Breast Metastasis from Neuroendocrine Carcinoma of the Lung: A Case Report and Review of the Literature

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