`Metered' aerosols of bronchodilator drugs in clinical trials: Influence of the method of administration

Cohen, Bevin

doi:10.1136/thx.26.3.316

Cited by 4 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The fact that some patients seem to derive more benefit from a bigger dose of salbutamol may be merely that they are not very competent at using their inhalers, and Cohen (1971) showed that the "breath-actuated" and "physician-given" methods of administration were superior to the patient-administered method. It would seem better to ensure that patients receive the inhalant in the prescribed dose by accurate inhalation than that the inhaler is used excessively, but inefficiently.…”

Section: Present Investigationmentioning

confidence: 99%

Effects of Salbutamol and Isoprenaline Phenylephrine in Reversible Airways Obstruction

Alliott¹,

Lang²,

Rawson³

et al. 1972

BMJ

View full text Add to dashboard Cite

S39 examination showed delayed gastric emptying with a lesser curve gastric ulcer. Acid secretory studies showed no response to insulin, indicating a complete vagotomy. At reoperation, eight months after the first operation, a lesser curve gastric ulcer was present but no duodenal ulcer. He is now well after antrectomy.Case 3.-An insulin test was negative three months after vagotomy in a man aged 37. After one year he developed epigastric pain and vomiting and barium meal examination showed a lesser curve gastric ulcer with normal gastric emptying. The ulcer was confirmed by gastroscopy. Conservative treatment of the ulcer was undertaken and further gastroscopy showed that the ulcer was healing. Fourteen months after the operation and two months after the development of a gastric ulcer a barium meal examination showed an apparently normal stomach which still emptied normally. He was then symptom-free. DiscussionThe idea of treating patients with duodenal ulceration by vagotomy without a drainage operation is attractive and has been the goal of many surgeons. Dragstedt and Owens (1943) Jrournal, 1972, 1, 539-542 Summary Ventolin (salbutamol) and Medihaler-Duo (isoprenaline/ phenylephrine combination) standard pressurized inhalers were used to administer doses of two or six "puffs" to 16 patients with known reversible airways obstruction.The doses were administered in random order over two days. Both the Ventolin and Medihaler-Duo inhalers substantially increased FEV1, but in the doses used salbutamol was more effective than isoprenaline/phenylephrine (P < 001). There was no significant difference between two and six puffs of salbutamol, though there seemed to be an advantage of six puffs of isoprenaline/ phenylephrine over two puffs (P < 0 05). Adrenaline (1/1,000) 0 5 ml and atropine 0 6 mg produced similar increases in FEV1 to those produced by salbutamol.County Hospital, Hereford R.

show abstract

Section: Present Investigationmentioning

confidence: 99%

Effects of Salbutamol and Isoprenaline Phenylephrine in Reversible Airways Obstruction

Alliott¹,

Lang²,

Rawson³

et al. 1972

BMJ

View full text Add to dashboard Cite

show abstract

“…Tektronix, Inc., Beaver ton, Oreg. medication, and the patients before, and 5 min after two inhalations of an isoproter enol-phenylephrine mist delivered from a breath-actuated hand nebulizer (Duohaler®, Riker-3M Laboratories, Northridge, Calif.) [10,11]. Table I lists the mean respiratory test values and their standard devia tions for the 200 subjects according to the predominant color patterns produced during shallow panting.…”

Section: Methodsmentioning

confidence: 99%

Color Presentation of Breath Sounds

Cohen¹

1972

Respiration

View full text Add to dashboard Cite

A simple ‘color-organ’-loudspeader assembly was connected to a microphone inserted in the mouthpiece of a whole body volume-displacement plethysmograph to record panting breath sound frequencies as color patterns for 50 normal subjects studied at rest, and 150 patients with chronic obstructive ventilatory disorders examined before, and 5 min after inhalation of an isoproterenol-phenylephrine aerosol. The color displays were related to spirometric and plethysmographic indices. The respiratory function means were poorest for subjects breathing in the blue (lowest) frequency range, with increasingly better mean data for groups in the mixed blue/red, red and green frequencies. Although there was a modest degree of overlapping between the groups, differences in intergroup means were significant at the 0.01 level or better for all indices except certain Vtg comparisons. The breath sounds of the majority of normal subjects fell into the green or red (highest) frequencies, with the progressively abnormal function of the patient subdivisions marked by increasing numbers breathing in the blue/red and blue ranges. These color patterns were function-directed, rather than primarily related to age or diagnosis. Improved mean indices following bronchodilator mist exposure were accompanied by a shift into higher color frequencies, with changes in [Rg×Vtg] and Ra of equal magnitude to alterations in FEF_{200 – 1,200} and FEV_1•0These data suggest that color presentation of oral respiratory sounds is a simple and inexpensive semi-quantitative method of estimating ventilatory status and the response to bronchoactive drugs.

show abstract