Methanol Ingestion

Fein, Daniel M.; Sue, Young-Jin

doi:10.1542/pir.32-12-549

Cited by 4 publications

(5 citation statements)

References 3 publications

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“…Formic acid is tested to be the critical toxicant in the animal with a reduced capacity to metabolize this lethal output toxicity may happen from an excellent anion passage metabolic acidosis and neuronal toxicity. 4 Experimental research demonstrates that there are many adverse health effects of consequences of food alcohols included liver cirrhosis, the mental illness, and numerous kinds of cancer and other. Human exposure to CH 3 OH necessarily happens via the ingestion of alcoholic beverages and fruit juices, use of cosmetics, deicing fluids, varnishes, and perfumes.…”

Section: Discussionmentioning

confidence: 99%

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Study on Agarwood and caspase-3 activation in rat liver toxicity induced by methanol

Hamouda¹

2018

PPIJ

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Agar wood has been applied to traditional medicine and used as perfumery and food ingredients especially in Saudi Arabia. It contains bio molecules component that shows various pharmacological, anti-mutagenic, anti-tumor and anti-helminthic, antioxidant and other advantages effects. Reactive oxygen species (ROS) produced during the detoxification of xenobiotics and drugs that generated oxidative stress and apoptosis. Caspase-3 is the central executioners, a cysteine protease, during apoptosis and cell death. The effect of Agar wood hexane extract on liver death through studied of nitric oxide (NO), malondialdehyde (MDA), caspase-3 levels and liver function tests in rats treat and untreated with an intra peritoneal dose of 3g/kg methanol was studied in this investigation. Injected of rats with methanol-induced an elevation in the levels of NO, MDA, caspase-3, and liver function tests, compared to the control. Treatment of animals with Agar wood extracts pre, during, and post methanol administration improved liver function and decreased the levels of NO, MDA, and caspase-3 activities compared to the methanol group, indicates that Agar wood diminished the oxidative stress and apoptosis induced by methanol, this may be due to its Phytochemical compositions.

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Section: Discussionmentioning

confidence: 99%

“…Methanol toxicity may initially appear in CNS depression, followed by a possible asymptomatic period metabolic acidosis and ocular toxicity that may end in blindness, are resulting manifestations of digestive problems toxicity, coma, and death. 4,5 . Natural food and herbs are conventional to treat toxicity, chronic and acute illness.…”

Section: Introductionmentioning

confidence: 99%

Study on Agarwood and caspase-3 activation in rat liver toxicity induced by methanol

Hamouda¹

2018

PPIJ

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“…Methanol intoxication may result from vapour inhalation and transdermal absorption, but most cases of methanol toxicity globally arise from ingestion of adulterated beverages. In the United States, cases generally occur from ingestion of windshield wiper fluid 14 .…”

Section: Medical Issues and Pathophysiologymentioning

confidence: 99%

A review of methanol poisoning: a crisis beyond ocular toxicology

Pressman¹,

Clemens

Sahu

et al. 2020

Cutaneous and Ocular Toxicology

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At first blush, methanol poisoning may be seen as an arcane problem generally associated with rapid ocular neuropathy. The emerging clinical reality is that methanol poisoning around the globe has claimed increasingly large numbers of deaths largely due to the press of poverty and the delay in suspecting and diagnosing methanol toxicity. With the onset of the COVID-19 pandemic, false beliefs about methanol's preventive potential vs viral infection of have arisen. In March of this year, more than 300 Iranians died and 1000 became ill after consuming methanol in the hope that it would protect them against the novel coronavirus. We review the context and magnitude of methanol toxicity, pathophysiology, principal medical issues, and human variability in metabolism. While toxicologists and clinicians may need to be especially attentive to this problem, it is becoming clear that the social and economic underpinnings of the methanol poisoning crisis must be actively and urgently explored and managed as vigorously as its toxicologic and pathophysiologic components. ARTICLE HISTORY

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“…It is also used as a fuel for race cars, boats, and airplanes, as it burns cleaner than gasoline. Methanol is a popular alternative fuel source because it is renewable, abundant, and can be produced from a variety of sources [1].…”

Section: Introductionmentioning

confidence: 99%

The Role of Nephrologists in the Management of Methanol Poisoning

Allata¹,

Chouhani²,

bardai³

et al. 2023

Cureus

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Acute methanol poisoning is a rare but serious condition that can lead to significant morbidity and mortality. Toxic metabolites produced by methanol, primarily formaldehyde, can cause high anion gap metabolic acidosis, with the severity of clinical presentation ranging from mild symptoms to multi-organ failure. Nine people died and four patients needed treatment at our university hospital following a collective intoxication caused by the consumption of homemade alcoholic beverages in the central region of Morocco. The four patients presented to the emergency department with varying clinical symptoms, such as decreased visual acuity, severe agitation, and dyspnea. The laboratory tests confirmed high anion gap metabolic acidosis and a subsequent toxicology screen revealed that they had consumed methanol-tainted alcohol. The treatment regimen involved inhibiting the formation of toxic metabolites using an antidote (ethanol or fomepizole), correcting metabolic acidosis, enhancing the elimination of toxic metabolites through prolonged hemodialysis, and administering adjunctive therapies. While two patients had favorable outcomes, the other two died from multi-organ failure. These findings highlight the importance of prompt diagnosis and treatment in cases of methanol poisoning.

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Methanol Ingestion

Cited by 4 publications

References 3 publications

Study on Agarwood and caspase-3 activation in rat liver toxicity induced by methanol

Study on Agarwood and caspase-3 activation in rat liver toxicity induced by methanol

A review of methanol poisoning: a crisis beyond ocular toxicology

The Role of Nephrologists in the Management of Methanol Poisoning

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