Method development and validation for the simultaneous determination of fluoxetine and fluvoxamine in pharmaceutical preparations by capillary electrophoresis

Nevado, J. J. Berzas; Salcedo, A.M. Contento; Llerena, M. J. Villaseñor; Nuevo, E. Aguas

doi:10.1016/s0003-2670(00)00926-0

Cited by 54 publications

(21 citation statements)

References 8 publications

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“…12,13) Most of the spectrophotometric methods reported for determination of FXT involve difficult and timeconsuming extraction procedures. Giridhar and coworkers determined FXT hydrochloride spectrophotometrically in bulk and in pharmaceutical formulations after extraction of its yellow ion-pair complex by methyl orange and thymol blue with chloroform.…”

Section: Fluoxetine (Fxt) Hydrochloride N-methyl-3-phenyl-3-[4-mentioning

confidence: 99%

Spectrophotometric Determination of Fluoxetine by Batch and Flow Injection Methods

Afkhami

Madrakian

Khalafi

2006

CHEMICAL & PHARMACEUTICAL BULLETIN

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Section: Fluoxetine (Fxt) Hydrochloride N-methyl-3-phenyl-3-[4-mentioning

confidence: 99%

Spectrophotometric Determination of Fluoxetine by Batch and Flow Injection Methods

Afkhami

Madrakian

Khalafi

2006

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…Up to now several papers describe the analysis of antidepressants using different electroseparation methods. These investigations employ capillary electroseparation methods with UV detection for either the separation of standard mixtures [14] or the determination of these analytes in biological fluids [15][16][17][18][19][20] or in pharmaceutical formulations for quality assurance purposes [21][22][23][24][25]. There are only three reports describing the use of CZE with mass spectrometric detection for the analysis of either a single antidepressant and its metabolites [26] or some substances with closely related chemical structures [27].…”

Section: Introductionmentioning

confidence: 99%

Determination of antidepressants in surface and waste water samples by capillary electrophoresis with electrospray ionization mass spectrometric detection after preconcentration using off‐line solid‐phase extraction

2006

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A method for the quantitative determination of seven major antidepressants in surface waters and sewage treatment plant effluents by CE using ESI-MS is presented. Calibration curves for the selected analytes were prepared in Milli-Q purified water and Danube river water extract covering a concentration range of at least one order of magnitude. LODs achieved were between 6 and 13 microg/L for Trazodone and 39 and 53 microg/L for Sertraline in the Milli-Q purified water and Danube river water matrix, respectively. For sample preparation eight different SPE materials were investigated. Best results were obtained for a resin based on hydrophilic divinylbenzene (recoveries from Milli-Q purified water 93-96%; from Danube river water 85-99%). Finally, a series of eight sewage treatment plant effluents were investigated with respect to their content in the selected antidepressants. Six of these samples were tested positive for antidepressants, in particular Venlafaxine, Citalopram and Trazodone in concentrations between 36 and 322 ng/L.

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“…A survey of literature revealed that spectrophotometric 3,4 , spectrofluorimetric 5,6 , electrochemical 7 , gas chromatography 8 , liquid chromatography [9][10][11] , capillary zone electrophoresis (CZE) 12 methods for determination of FH from pharmaceutical formulation and spectrophotometric [13][14][15][16][17] , linear voltametric 16 , HPLC [16][17][18] , CZE 18 methods for determination of OZ from pharmaceutical dosage form whereas HPLC [19][20][21][22] and HPTLC 21,22 methods for the simultaneous determination of FH and OZ from combined dosage forms were reported.…”

Section: Fig 1b: Olanzapine Figure 1a and B: Chemical Structures Of Flmentioning

confidence: 99%

Untitled

2011

IJPSR

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Fluoxetine hydrochloride (FH) in combination with Olanzapine (OZ) is used in treatment of depressive episodes associated with bipolar disorder. The first derivative spectrophotometric method for simultaneous determination of fluoxetine hydrochloride (FH) and olanzapine (OZ) from two component tablet dosage form has been developed and validated. Chromatographic methods viz. HPLC and HPTLC methods were reported in the literature for the simultaneous determination of FH and OZ from combined dosage forms. In the present investigation an attempt has been made to develop accurate, reproducible, rapid and cost-effective method for simultaneous determination of FH and OZ in pharmaceutical formulation. The wavelengths selected for determination of FH and OZ is 235.5nm and 296nm, respectively. The beer's law was obeyed in the concentration range of 8-80μg/mL and 2-20μg/mL for Fluoxetine and Olanzapine, respectively. The proposed methods were validated and successfully applied to the determination of FH and OZ in tablet formulations. The results suggested that the proposed procedures can be used for routine quality control of tablets containing FH and OZ.

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Method development and validation for the simultaneous determination of fluoxetine and fluvoxamine in pharmaceutical preparations by capillary electrophoresis

Cited by 54 publications

References 8 publications

Spectrophotometric Determination of Fluoxetine by Batch and Flow Injection Methods

Spectrophotometric Determination of Fluoxetine by Batch and Flow Injection Methods

Determination of antidepressants in surface and waste water samples by capillary electrophoresis with electrospray ionization mass spectrometric detection after preconcentration using off‐line solid‐phase extraction

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