Method for Measuring Laser Frequency Noise

Лиокумович, Л. Б.; Kostromitin, Aleksei O.; Ushakov, Nikolai; Kudryashov, Alexis

doi:10.1007/s10812-020-00947-x

Cited by 5 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Сущность метода самобиений состоит в том, что свет, рассеянный исследуемым участком образца, направляется на фотоприемник, на котором и возникают биения между различными частотными компонентами спектра падающего света [34]. При этом ток фотоприемника оказывается промодулированым по амплитуде частотами биений флуктуаций концентраций частиц под воздействием света, рассеянного на исследуемом образце от нуля до ширины спектра рассеяния [35]. Релаксация микроскопических флуктуаций концентрации частиц к равновесному состоянию описывается уравнением диффузии:…”

Section: резюмеunclassified

Algorithm of rapid diagnosis of chronic autoimmune hepatitis by saliva by the method of monochrome analysis of nanoparticles

Choi¹

2022

jour

View full text Add to dashboard Cite

Сhronic autoimmune hepatitis is an urgent problem of modern medicine due to the widespread prevalence among all autoimmune diseases (more than 25%) and the diffi culty of its diagnosis due to the lack of reliable serological tests for its detection. The purpose of this work was to study the possibility of the method of monochrome analysis of nanoparticles in noninvasive detection of AIG and to develop an algorithm for rapid diagnosis of chronic autoimmune hepatitis by saliva.The goal was solved by performing a number of tasks: the development of a diagnostic algorithm for monochrome analysis of nanoparticles to determine the severity and pathophysiological orientation of homeostatic shifts in patients with a verifi ed diagnosis of chronic autoimmune hepatitis using samples of oropharyngeal fl ushes (saliva), as well as the calculation of diagnostic specifi city and sensitivity of the test. Materials and methods:The studies were conducted at the Center for European and Oriental Medicine from 2019 to 2022, and 14 patients with a verifi ed diagnosis of autoimmune hepatitis were examined. It was found that the most typical saliva spectra of patients with autoimmune liver damage were characterized by three-modality and predominance of light scattering on particles of super-large diameter (over 1000 nm) and a signifi cant increase in the contribution to light scattering of nanoparticles of small and medium hydrodynamic size, which was statistically signifi cant (p<0.001) when conducting a comparative analysis with the saliva spectra of practically healthy individuals and patients with general somatic liver diseases of non-autoimmune genesis. The indicators of diagnostic sensitivity for autoimmune hepatitis were 95%, diagnostic specifi city -93%.Conclusions: the results of the conducted scientifi c research were the developed algorithm for the use of laser spectroscopy of saliva for noninvasive rapid diagnosis of chronic autoimmune hepatitis, when with a timely diagnosis, therapeutic measures will be maximally eff ective and aimed at preventing complications and systemic manifestations of the disease, and the calculation of diagnostic sensitivity and specifi city of the method of monochrome analysis of nanoparticles.

show abstract

Section: резюмеunclassified

Algorithm of rapid diagnosis of chronic autoimmune hepatitis by saliva by the method of monochrome analysis of nanoparticles

Choi¹

2022

jour

View full text Add to dashboard Cite

show abstract

“…The circuit elements selected according to calculated requirements provided signal-to-noise ratio (SNR) of more than 10 for all detected signals [28]. SNR was calculated using [34][35][36]. The choice of the photomultiplier is discussed in detail in our recent article [36] and is explained by main features of the spectrometer, which are very weak scattered radiation signals (~−70 dBm), low-frequency nature of the received signals (<100 kHz), and low background illumination due to the use of optical fibers in the optical scheme.…”

Section: Dynamic Light Scattering Spectrometermentioning

confidence: 99%

Molecular Aggregation in Immune System Activation Studied by Dynamic Light Scattering

Velichko

Makarov

Nepomnyashchaya

2020

Biology

View full text Add to dashboard Cite

Determination of the concentration and size of the circulating immune complexes in the blood is an essential part of diagnostics of immune diseases. In this work, we suggest using the dynamic light scattering method to determine the sizes of circulating immune complexes in blood serum. By the dynamic light scattering spectrometer, we found that for healthy and sick donors, the size and concentration of circulating immune complexes differed significantly. The dynamics of formation of these complexes were also examined in this work. It was shown that the formation of immune complexes in the blood of healthy donors is faster than the same reactions in the blood serum of donors with diseases. The results can be used in the diagnostics of the immune status and detection of chronic inflammation. We can recommend the dynamic light scattering method for implementation in biomedical diagnostics.

show abstract

“…The signal fluctuations of the medium optical density occur during the measurements. Their deviation from the average value, as a rule, does not reach 0.5% [ 19 , 20 ]. Fluctuations in optical density can be conditioned by fluctuations of dye concentration, intensity measurement error is mostly determined by photodetector quantization error.…”

Section: Experimental Setup Of Optical Densitometrymentioning

confidence: 99%

Design of Liver Functional Reserve Estimation Technique Based on Optical Densitometry

et al. 2020

View full text Add to dashboard Cite

This work is aimed at creating a modified invasive technique for assessing the liver’s functional reserves. A study of the degree of hepatodepression is carried out by measuring the plasma elimination of indocyanine green using the method of optical densitometry. This paper presents test results for an aqueous solution and an albumin solution, as well as the results of measurements of plasma elimination of indocyanine green for patients with liver disease. Perfecting the proposed method will make an important scientific contribution to modern diagnostic medicine. Diagnosing the stages in the progression of the disease and its developing complications can make it possible to rapidly correct the patient’s treatment algorithm, achieving positive outcomes in medical practice.

show abstract

Method for Measuring Laser Frequency Noise

Cited by 5 publications

References 10 publications

Algorithm of rapid diagnosis of chronic autoimmune hepatitis by saliva by the method of monochrome analysis of nanoparticles

Algorithm of rapid diagnosis of chronic autoimmune hepatitis by saliva by the method of monochrome analysis of nanoparticles

Molecular Aggregation in Immune System Activation Studied by Dynamic Light Scattering

Design of Liver Functional Reserve Estimation Technique Based on Optical Densitometry

Contact Info

Product

Resources

About