Methodology and effects of repeated intranasal delivery of DNSP-11 in awake Rhesus macaques

Stenslik, Mallory J.; Evans, April; Pomerleau, François; Weeks, R. A.; Huettl, Peter; Foreman, Emma; Turchan–Cholewo, Jadwiga; Andersen, Anders H.; Cass, Wayne A.; Zhang, Z.; Grondin, Richard; Gash, Don M.; Gerhardt, Greg A.; Bradley, Luke H.

doi:10.1016/j.jneumeth.2018.03.006

Cited by 10 publications

(1 citation statement)

References 75 publications

(138 reference statements)

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“…The IN delivery of proteins and peptides to the CNS allows for the treatment of neurodegenerative diseases such as AD [103], PD [104][105][106], and multiple sclerosis [107,108], among others. However, despite many published articles using the N-to-B route to target peptides and protein to the CNS, nearly all use liquid formulations like emulsions, suspensions, and sprays, among others, and only a few use formulations in solid-state.…”

Section: Nasal Dpi Peptides For Cns Therapy/disease Applicationmentioning

confidence: 99%

Nose-to-Brain Delivery of Therapeutic Peptides as Nasal Aerosols

et al. 2022

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Central nervous system (CNS) disorders, such as psychiatric disorders, neurodegeneration, chronic pain, stroke, brain tumor, spinal cord injury, and many other CNS diseases, would hugely benefit from specific and potent peptide pharmaceuticals and their low inherent toxicity. The delivery of peptides to the brain is challenging due to their low metabolic stability, which decreases their duration of action, poor penetration of the blood-brain barrier (BBB), and their incompatibility with oral administration, typically resulting in the need for parenteral administration. These challenges limit peptides’ clinical application and explain the interest in alternative routes of peptide administration, particularly nose-to-brain (N-to-B) delivery, which allows protein and peptide drugs to reach the brain noninvasively. N-to-B delivery can be a convenient method for rapidly targeting the CNS, bypassing the BBB, and minimizing systemic exposure; the olfactory and trigeminal nerves provide a unique pathway to the brain and the external environment. This review highlights the intranasal delivery of drugs, focusing on peptide delivery, illustrating various clinical applications, nasal delivery devices, and the scope and limitations of this approach.

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