Methods for Radiolabelling Nanoparticles: PET Use (Part 2)

Bentivoglio, Valeria; Varani, Michela; Lauri, Chiara; Ranieri, Danilo

doi:10.3390/biom12101517

Cited by 3 publications

(4 citation statements)

References 102 publications

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“…Finally, radiolabeled nanoparticles (NPs) are a potential nuclear medicine technology for diagnostic and therapeutic purposes. Magnetic nanoparticles (NPs) can be used in nuclear medicine to diagnose and treat [72][73][74]. Unak et al [75] used superparamagnetic iron oxide (SPION) NPs labeled with two scandium radionuclides, 44 Sc and 47 Sc, for detecting and treating prostate cancer.…”

Section: Deoxyuridine (Iudr) Glioblastomamentioning

confidence: 99%

Three-Dimensional In Vitro Tumor Spheroid Models for Evaluation of Anticancer Therapy: Recent Updates

Nayak,

Bentivoglio,

Varani

et al. 2023

Cancers

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Advanced tissue engineering processes and regenerative medicine provide modern strategies for fabricating 3D spheroids. Several different 3D cancer models are being developed to study a variety of cancers. Three-dimensional spheroids can correctly replicate some features of solid tumors (such as the secretion of soluble mediators, drug resistance mechanisms, gene expression patterns and physiological responses) better than 2D cell cultures or animal models. Tumor spheroids are also helpful for precisely reproducing the three-dimensional organization and microenvironmental factors of tumors. Because of these unique properties, the potential of 3D cell aggregates has been emphasized, and they have been utilized in in vitro models for the detection of novel anticancer drugs. This review discusses applications of 3D spheroid models in nuclear medicine for diagnosis and therapy, immunotherapy, and stem cell and photodynamic therapy and also discusses the establishment of the anticancer activity of nanocarriers.

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Section: Deoxyuridine (Iudr) Glioblastomamentioning

confidence: 99%

Three-Dimensional In Vitro Tumor Spheroid Models for Evaluation of Anticancer Therapy: Recent Updates

Nayak,

Bentivoglio,

Varani

et al. 2023

Cancers

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“…Iron-oxide NPs can be radiolabeled without with a chelator utilizing a heat-induced metal-ion-binding method, which avoids the use of a multi-step radiolabeled process by using a diagnostic radioisotope in the indirect approach [ 4 ].…”

Section: Radiolabeling Of Nps With Alpha-emitting Isotopesmentioning

confidence: 99%

“…Several isotopes can emit Auger's electrons, such as 64 Cu, 161 Tb, 195m Pt, 111 In, 67 Ga, 99m Tc, 125 I, 124 I, and 123 I. However, most of these isotopes are used for diagnostic purposes and have already been described in the Part 1 and Part 2 reviews [3,4].…”

Section: Radiolabeling Of Nps With Auger's Electron-emitting Isotopesmentioning

confidence: 99%

“…We previously published two systematic reviews on “methods for radiolabeling nanoparticles for diagnostic SPECT use” [ 3 ] and “methods for radiolabeling nanoparticles for diagnostic PET use” [ 4 ]. This paper addresses a systematic review of the published research on “methods for radiolabeling nanoparticles for therapy”, including an Auger’s electron-emitting, Alpha-emitting, and Beta-emitting isotopes.…”

Section: Introductionmentioning

confidence: 99%

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Methods for Radiolabeling Nanoparticles (Part 3): Therapeutic Use

et al. 2023

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Following previously published systematic reviews on the diagnostic use of nanoparticles (NPs), in this manuscript, we report published methods for radiolabeling nanoparticles with therapeutic alpha-emitting, beta-emitting, or Auger’s electron-emitting isotopes. After analyzing 234 papers, we found that different methods were used with the same isotope and the same type of nanoparticle. The most common type of nanoparticles used are the PLGA and PAMAM nanoparticles, and the most commonly used therapeutic isotope is 177Lu. Regarding labeling methods, the direct encapsulation of the isotope resulted in the most reliable and reproducible technique. Radiolabeled nanoparticles show promising results in metastatic breast and lung cancer, although this field of research needs more clinical studies, mainly on the comparison of nanoparticles with chemotherapy.

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Nanoparticles for Dual Imaging: Pet and Fluorescence Imaging

SARCAN

2024

Ankara Ecz. Fak. Derg.

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Objective: Molecular imaging methods are gaining popularity in clinical and preclinical fields. There are many different imaging methods such as computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), single photon emission computed tomography (SPECT) and Near-infrared fluorescence (NIRF), and each has different advantages and disadvantages. Multimodal imaging methods, a combination of two or more molecular imaging modalities, have been developed to overcome the disadvantages of these molecular imaging methods. However, these imaging methods are conjugated with different vectors to improve the multimodal imaging methods used. In this field, drug delivery systems, peptides, proteins, antibodies and aptamers have been widely used for conjugation of multimodal imaging modalities to overcome some of the disadvantages that come from imaging modalities. In this review, PET and NIRF combination imaging modalities were explained and more specifically PET and NIRF nanoparticle dual imaging modalities with their pros and cons were investigated. Result and Discussion: Dual imaging modalities overcome to limitations of single imaging modalities and provide a better understanding of biological, anatomical, and physiological processes. Multimodal imaging modalities offer higher sensitivity, resolution, and specificity with lower cost and toxicity although have several disadvantages.

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Methods for Radiolabelling Nanoparticles: PET Use (Part 2)

Cited by 3 publications

References 102 publications

Three-Dimensional In Vitro Tumor Spheroid Models for Evaluation of Anticancer Therapy: Recent Updates

Three-Dimensional In Vitro Tumor Spheroid Models for Evaluation of Anticancer Therapy: Recent Updates

Methods for Radiolabeling Nanoparticles (Part 3): Therapeutic Use

Nanoparticles for Dual Imaging: Pet and Fluorescence Imaging

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