Methods for the Functionalisation of Nanoparticles: New Insights and Perspectives

Abstract

In the field of nanometre-sized drug-delivery systems, a wide range of colloidal systems have been created in recent decades. All of the systems have a similar global structure, that is, an inner part and an external surface/interface. In several applications, the external interface is the support for desired properties and the basis of future developments. The engineering of the particle's surface is an emerging step in the design of systems at the nanometre scale. This review presents and summarises the available techniques with a particular attention to recent advances. It is also a base for future works in this expanding area of research.

Nanoparticles under the Light: Click Functionalization by Photochemical Thiol‐yne Reaction, Towards Double Click Functionalization

“…1. This chemical development collides with another growing field: the engineering of nanoparticle surface functionalization 2. In the domain of nanobiomedecine, the use of click chemistry has become predominant among the plethora of existing functionalization methodologies due to its versatility, simplicity, selectivity, and biocompatibility.…”

Diazo transfer at polydopamine – a new way to functionalization

“…[1][2][3] Magnetic nanoparticles (MNP) are among the pillars of this field. 4 They have been widely used in medicine, 5 as drug delivery systems, 6,7 resonance imaging, 8 and as support for metal catalysts and organocatalysts. [9][10][11] Different coating agents have been used for covering MNP, 12,13 for example polymers like dextrane, 14 polyvinyl alcohol, 15 polypyrrole, 16 polyacrylates 17 and others.…”

Hybrid silica nanoparticles traceable by fluorescence and FT-IR spectroscopy: preparation, characterization and preliminary biological studies

“…This step usually provides the particles with low immunogenicity, 9 improved biocompatibility, 10 and versatile functionalities. 11,12 More specifically, combining different surface functional groups and/or core/surface phases may potentially result in NPs and nanosystems that will possess merged or synergistic physico-chemical features. 13 Therefore, carefully designing and engineering the structural and/or functional ''complexity'' issue in nanoparticulate systems will be an essential and required step towards multifunctional and multimodal nanocomposite materials.…”