The multidisciplinary collaboration can be efficiently supported by the Model-Based Systems Engineering (MBSE) approach. However, even if the MBSE approach presents a brilliant method of development of complete architectures, this approach does not avoid system defects during or after the development process. In this paper, we describe the benefits to integrate agile methods into MBSE approaches and we propose in particular to introduce the Agile Scrum method in a MBSE design methodology for multidisciplinary systems.