Methyl-substituted 4-nitropyridine N-oxides as ligands: Structural, spectroscopic, magnetic and cytotoxic characteristics of copper(II) complexes

Electronic spectra and crystal structure of dinuclear Cu(II) ‘paddle wheel’ acetate complex containing axially coordinated 3-methyl-4-nitropyridine-N-oxide

“…However, it is also much longer than such distance in the monomeric copper complexes with mnpn (1.9623 Å ) [12].…”

“…In contrast to copper chloride and nitrate forming mostly mononuclear four coordinate complexes with various methyl derivatives of 4-nitro-pyridine N-oxide [12,13], copper acetate interaction with mnpn results in the precipitation of only one product, i.e. a dinuclear [Cu 2 (OAc) 4 (3-mnpn) 2 ] (compound 1).…”

“…Only with 3-methyl-4-Nitropyridine-N-oxide little, blue green crystals were formed after 24 h. The crystals were collected, washed with ethanol and dried on air. IR data (the assignment of 3 mnpn were performed according to the literature data [12,[18][19][20][21]) and the data for compound 1 in the brackets: m(C=C) m(C=N)-1603m (1607w); m as (COO)-(1625); m a (COO)-(1435vs); m as (NO 2 )-1570m, 1508s (1580w, 1522 s); m s (NO 2 )-1343vs (1352s); m(NO)-1302vs, 1262vs, 1230vs (1300vs, 1249vs, 1235vs); d as (CH 3 )-1474w, 1462vs, 1417w (1481w); m(Cu-O org. lig ) -(444w); m (Cu-O acetate )-(361w).…”

“…Recently, it was found that they can also be a potentially useful in nonlinear optical devices [10,11]. Copper(II) complexes with these ligands exhibited also a significant anti-proliferative activity against various human cancer lines [12,13]. The complexes are mostly mononuclear, four coordinate species of the type [Cu(X) 2 L 2 ] with two inorganic (X = Cl -, NO 3 -) and two mnpn ligands (L) in trans position.…”

Synthesis and structure of new dicopper(II) complexes bridged by N-(2-hydroxy-5-methylphenyl)-N′-[3-(dimethylamino)propyl]oxamide with in vitro anticancer activity: A comparative study of reactivities towards DNA/protein by molecular docking and experimental assays

“…In this context, copper, as a biologically essential metal element, shows many correlations with endogenous oxidative DNA damage associated with aging and cancer, and much attention has been paid to the synthesis and activity evaluation of copper-based complexes showing promising antitumor properties [5][6][7][8][9][10]. It is established that the increased hydrophobicity of primary and coligands can enhance the DNA/protein binding abilities in some mono copper (II) complexes [11][12][13] [14]. To the best of our knowledge, there are no studies on the influence of the increased synergistic hydrophobicity of bridging and terminal ligands in dicopper(II) complexes on DNA/protein binding abilities and in vitro anticancer activities.…”