Methylation of the hsa-miR-124, SOX1, TERT, and LMX1A genes as biomarkers for precursor lesions in cervical cancer

Rogeri, Caroline Domingues; Silveira, Henrique C. S.; Causin, Rhafaela Lima; Villa, Luisa L.; Stein, Maíra Degiovani; Carvalho, Ana Carolina de; Arantes, Lídia Maria Rebolho Batista; Scapulatempo‐Neto, Cristovam; Possati-Resende, Júlio César; Antoniazzi, Márcio; Longatto‐Filho, Adhemar; Fregnani, José Humberto Tavares Guerreiro

doi:10.1016/j.ygyno.2018.06.014

Cited by 56 publications

(55 citation statements)

References 35 publications

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“…Downregulation of plasma miR-124 expression was a predictive biomarker for prognosis of glioma [10,22]. A large number of previous studies have suggested that miR-124 could be used as a molecular marker for tumor progression in cervical cancer [23,24], breast cancer [12,25,26], lung cancer [27,28], and osteosarcoma [29]. Numerous clinical studies have shown that BRCA is the most common type of breast cancer and has poor prognosis survival, and the pathogenesis of breast cancer involves a variety of factors and genes [4,30].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Role of hsa-mir-124 in Predicting Clinical Outcome in Breast Invasive Carcinoma Based on Bioinformatics Analysis

Feng

Zhang

Sun

et al. 2020

BioMed Research International

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Purpose. Breast invasive carcinoma (BRCA) is the most common malignant tumor. MiR-124 plays a tumor-suppressive role in human cancer. However, the clinical significance of miR-124 in BRCA remains unclear. The aim of this study was to evaluate the association of hsa-mir-124 expression and the clinicopathological characteristics in BRCA using database analysis. Methods. The clinical data and expression profiles of hsa-mir-124 were obtained from the cancer genome atlas for BRCA (TCGA_BRCA). Then, the prognostic value of hsa-mir-124 in BRCA was investigated using the Cox Regression test, and the association of hsa-mir-124 and pathology TNM stages and pathologic stages were measured by the Kruskal–Wallis test and Wilcox. test. In addition, the association of hsa-mir-124 and tumor molecular phenotypes was performed using the Chi-Square test. Results. We found that the overall survival of patients with high expression of hsa-mir-124-1 and hsa-mir-124-2 was better than that of patients with low expression of hsa-mir-124-1 and hsa-mir-124-2. And the expression of hsa-mir-124-1, hsa-mir-124-2, and hsa-mir-124-3 was mainly enriched in T1/T2 stages, NO/N1 stages, and M0 stages. Then, the expression of hsa-mir-124-1, hsa-mir-124-2, and hsa-mir-124-3 was negatively associated with tumor lymph node metastasis. Moreover, the expression of hsa-mir-124 was associated with tumor molecular phenotype in breast invasive carcinoma. Conclusion. Our findings indicated that hsa-mir-124 expressions were associated with overall survival, TNM stages, pathologic characteristics, and tumor molecular phenotype in BRCA via TCGA_BRCA database, providing a new biomarker and a potential therapeutic target for BRCA patients.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Role of hsa-mir-124 in Predicting Clinical Outcome in Breast Invasive Carcinoma Based on Bioinformatics Analysis

Feng

Zhang

Sun

et al. 2020

BioMed Research International

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“…LMX1A has been recently reported to be hypermethylated in cervical cancers (Rogeri et al, 2018). LMX1A is a suppressor of tumorigenesis and metastasis of cervical cancer; however, the regulation of LMX1A during tumorigenesis remains to be understood.…”

Section: Diagnostic Dna Methylation Biomarkers For Hpv-positive and Nmentioning

confidence: 99%

DNA Methylation and Hydroxymethylation in Cervical Cancer: Diagnosis, Prognosis and Treatment

Zhu

Tian

et al. 2020

Front. Genet.

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Recent discoveries have led to the development of novel ideas and techniques that have helped elucidate the correlation between epigenetics and tumor biology. Nowadays, the field of tumor genetics has evolved to include a new type of regulation by epigenetics. An increasing number of studies have demonstrated the importance of DNA methylation and hydroxymethylation in specific genes in the progression of cervical cancer. Determining the methylation and hydroxymethylation profiles of these genes will help in the early prevention and diagnosis, monitoring recurrence, prognosis, and treatment of patients with cervical cancer. In this review, we focus on the significance of aberrant DNA methylation and hydroxymethylation in cervical cancer and the use of these epigenetic signatures in clinical settings.

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“…As the miR‐124 level in cervical cancer tissues is significantly lower than in normal tissues, overexpression of miR‐124 in HPV‐positive cell lines (SiHa and CaSki) could significantly suppress cell proliferation and migration by regulating the IGFBP7 gene . Another HPV‐related study suggested that LMX1A gene methylation and the miR‐124‐2 gene were predictors of the presence of high‐grade lesions, regardless of virus infection . The latest findings showed that miR‐124‐3p could suppress the proliferation and metastasis of cervical cancer by inhibiting the expression of insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP) …”

Section: Mir‐124 and Cervical Cancermentioning

confidence: 99%

“…97 Another HPV-related study suggested that LMX1A gene methylation and the miR-124-2 gene were predictors of the presence of high-grade lesions, regardless of virus infection. 98 The latest findings showed that miR-124-3p could suppress the proliferation and metastasis of cervical cancer by inhibiting the expression of insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP). 99 Many earlier studies have shown that miR-124 is associated with cervical cancer tumorigenesis and acts as a tumor suppressor gene.…”

Section: Mir-124 and Cervical Cancermentioning

confidence: 99%

MicroRNA‐124: An emerging therapeutic target in cancer

et al. 2019

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MicroRNAs (miRNAs) are noncoding single‐stranded RNAs, approximately 20‐24 nucleotides in length, known as powerful posttranscriptional regulators. miRNAs play important regulatory roles in cellular processes by changing messenger RNA expression and are widely involved in human diseases, including tumors. It has been reported in the literature that miRNAs have a precise role in cell proliferation, programmed cell death, differentiation, and expression of coding genes. MicroRNA‐124 (miR‐124) has reduced exparession in various human neoplasms and is believed to be related to the occurrence, development, and prognosis of malignant tumors. In our review, we focus on the specific molecular functions of miR‐124 and the downstream gene targets in major cancers, which provide preclinical evidence for the treatment of human cancer. Although some obstacles exist, miR‐124 is still attracting intensive research focus as a promising and effective anticancer weapon.

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Methylation of the hsa-miR-124, SOX1, TERT, and LMX1A genes as biomarkers for precursor lesions in cervical cancer

Cited by 56 publications

References 35 publications

Evaluation of the Role of hsa-mir-124 in Predicting Clinical Outcome in Breast Invasive Carcinoma Based on Bioinformatics Analysis

Evaluation of the Role of hsa-mir-124 in Predicting Clinical Outcome in Breast Invasive Carcinoma Based on Bioinformatics Analysis

DNA Methylation and Hydroxymethylation in Cervical Cancer: Diagnosis, Prognosis and Treatment

MicroRNA‐124: An emerging therapeutic target in cancer

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