Methylation status in healthy subjects with normal and high serum folate concentration

Hirsch, Sandra; Ronco, Ana María; Guerrero-Bosagna, Carlos; Maza, María Pía de la; Leiva, Laura; Barrera, Gladys; Llanos, Miguel; Alliende, María Angélica; Silva, Francisca; Bunout, Daniel

doi:10.1016/j.nut.2008.05.018

Cited by 28 publications

(26 citation statements)

References 35 publications

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“…These laboratory changes were consistent with increased oxidative stress and impaired methylation capacity in children with ASD ( James et al 2004). As shown in Figure 1, these abnormalities are related to three interconnected metabolic pathways known collectively as methionine transmethylation/transsulfuration metabolism (Hirsch et al 2008;Kalinina et al 2014;Watson et al 2014).…”

Section: Introductionsupporting

confidence: 53%

Open-Label Trial of Vitamin D3 Supplementation in Children with Autism Spectrum Disorder

Bent

Ailarov

Dang

et al. 2017

The Journal of Alternative and Complementary Medicine

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Objective: Children with autism spectrum disorder (ASD) have been reported to have reduced ability to methylate DNA and elevated markers of oxidative stress. We sought to determine if methyl B12, a key metabolic cofactor for cellular methylation reactions and antioxidant defense, could improve symptoms of ASD. Methods: A total of 57 children with ASD were randomly assigned to 8 weeks of treatment with methyl B12 (75 lg/kg) or saline placebo every 3 days in a subcutaneous injection. The primary outcome measure was overall improvement in symptoms of ASD as measured by the Clinical Global Impressions-Improvement (CGI-I) score. Secondary outcome measures included changes in the Aberrant Behavior Checklist (ABC) and the Social Responsiveness Scale (SRS). Laboratory measures of methionine methylation and antioxidant glutathione metabolism were assessed at baseline and 8 weeks.Results: A total of 50 children (mean age 5.3 years, 79% male) completed the study. The primary outcome measure -the clinician rated CGI-I score -was statistically significantly better (lower) in the methyl B12 group (2.4) than in the placebo group (3.1) (0.7 greater improvement in the methyl B12 group, 95% CI 1.2-0.2, p = 0.005). Clinical improvement among children treated with methyl B12 was positively correlated with increases in plasma methionine ( p = 0.05), decreases in S-adenosyl-lhomocysteine (SAH) ( p = 0.007) and improvements in the ratio of S-adenosylmethionine (SAM) to SAH ( p = 0.007), indicating an improvement in cellular methylation capacity. No improvements were observed in the parent-rated ABC or SRS. Conclusions: Methyl B12 treatment improved clinician-rated symptoms of ASD that were correlated with improvements in measures of methionine metabolism and cellular methylation capacity. Clinical Trial Registry: Efficacy Study of Subcutaneous Methyl B12 in Children with Autism: NCT01039792 (clinical trials.gov1).

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Section: Introductionsupporting

confidence: 53%

Open-Label Trial of Vitamin D3 Supplementation in Children with Autism Spectrum Disorder

Bent

Ailarov

Dang

et al. 2017

The Journal of Alternative and Complementary Medicine

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“…En este mismo grupo se observó un aumento durante la etapa post-fortificación, detectándose que el 100% presentaba ingesta superior al EAR. Considerando indicadores de folato sérico en un estudio desarrollado con posterioridad 7 , se observó que la ingesta de EDF estimada en adultos varones fue 3,2 veces superior al EAR, mientras que el 6% de ellos presentaba ingestas superiores al UL.…”

Section: Fortificación De Alimentos Y Límites Máximos De áCido Fólicounclassified

Cáncer de colon y su relación con la fortificación de ácido fólico

Guerrero-Wyss

Vásquez-Pincheira

2016

Rev Esp Nutr Hum Diet

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La fortificación de la harina de panificación en Chile con ácido fólico en mujeres embarazadas redujo en forma significativa los defectos del tubo neural, sin embargo esta situación también afecta al resto de la población. ¿Qué sucede con la suplementación en niños, adultos y adultos mayores que no requieren un aporte extra de ácido fólico? El objetivo de esta revisión es relacionar la fortificación de ácido fólico con el riesgo de desarrollar cáncer de colon. Algunos metaanálisis indican que la suplementación con folatos a largo plazo no aumentaría el riesgo relativo e incidencia de cáncer colorrectal, no obstante otros estudios creen pertinente estimar factible esta relación, ya que los datos no son concluyentes. La bibliografía disponible presenta resultados contradictorios; dependiendo del diseño metodológico del estudio, fuente de folato, dosis de fortificación y duración de ésta, además de la población objetivo; por lo que estas características deben ser consideradas en el análisis del riesgo de desarrollo de cáncer colorrectal. Se debe considerar que las pruebas no son concluyentes en relación a suplementación de folatos y el riesgo de desarrollar cáncer colorrectal. Los datos indican que la relación es dependiente de dosis y tiempo de administración, diseño metodológico, lugar geográfico del estudio, etnia de los sujetos, y otras variables como estilos de vida pudieron influir en algunos estudios. Se recomienda analizar futuros estudios realizados a nivel local y seguir con cautela la incidencia de cáncer colorrectal y relacionarlo con el desarrollo del programa de fortificación nacional con ácido fólico. PALABRAS CLAVE R E S U M E NCáncer de colon y su relación con la fortificación de ácido fólico

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“…SAM is formed from methyl groups derived from choline, methionine, or methyl-tetrahydrofolate, and is the primary methyl donor for the various methyltransferase enzymes within an organism (Zeisel, 2009). The end product of SAM metabolism is S-adenosylhomocysteine (SAH), which forms a negative feedback loop via direct inhibition of these methylation reactions (Hirsch et al, 2008;Piyathilake et al, 2008). There is a correlation between the availability of methyl groups in the diet and levels in an organism.…”

Section: Nutrition and The Enzymatic Process Of Dna Methylationmentioning

confidence: 99%

“…There is a correlation between the availability of methyl groups in the diet and levels in an organism. Specifically, it has been shown that the amount of folate in the diet can directly influence the level of these compounds in blood cells (Hirsch et al, 2008).…”

Section: Nutrition and The Enzymatic Process Of Dna Methylationmentioning

confidence: 99%

We are what we Eat: How Nutritional Compounds Such as Isoflavones Shape Our Epigenome

Guerrero-Bosagna

Clark

2011

Nutrition in Epigenetics

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Methylation status in healthy subjects with normal and high serum folate concentration

Cited by 28 publications

References 35 publications

Open-Label Trial of Vitamin D3 Supplementation in Children with Autism Spectrum Disorder

Open-Label Trial of Vitamin D3 Supplementation in Children with Autism Spectrum Disorder

Cáncer de colon y su relación con la fortificación de ácido fólico

We are what we Eat: How Nutritional Compounds Such as Isoflavones Shape Our Epigenome

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