Methylenetetrahydrofolate Reductase Gene Polymorphism (C677T) as a Risk Factor for Arterial Thrombosis in Georgian Patients

Garakanidze, Sopio; Costa, Elı́sio; Bronze-Rocha, Elsa; Santos-Silva, Alice; Nikolaishvili, Giorgi; Nakashidze, Irina; Kakauridze, N.; Glonti, Salome; Khukhunaishvili, Rusudan; Koridze, Marina; Ahmad, Sarfraz

doi:10.1177/1076029618757345

Cited by 13 publications

(8 citation statements)

References 23 publications

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“…Apo lipoprotein E (APOE) ( Rao et al, 2022 ), Angiotensinogen II Type 1 Receptor (AGTR1) ( Wulandari et al, 2018 ), Angiotensin-converting enzyme (ACE) ( Ya et al, 2019 ), methylenetetrahydrofolate reductase (MTHFR) ( Garakanidze et al, 2018 ), endothelin1 (EDN1) ( Yang et al, 2021 ), ring finger protein 213 (RNF213) ( Suzuki et al, 2018 ), Alpha-Adducin 1 (ADD1) ( Yermolenko et al, 2021 ), tumor necrosis factor (TNF) ( Khlynova et al, 2020 ) and T-box transcription factor 2 (TBX2) ( Abramova et al, 2020 ) involve in the AH process and the overexpression of them can cause amplification in AH.…”

Section: Discussionmentioning

confidence: 99%

Genetic and epigenetic factors of arterial hypertension: a bibliometric- and in-silico-based analyses

Karabaeva,

Vochshenkova,

Zare

et al. 2023

Front. Mol. Biosci.

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Introduction: Arterial hypertension (AH) is a pervasive global health concern with multifaceted origins encompassing both genetic and environmental components. Previous research has firmly established the association between AH and diverse genetic factors. Consequently, scientists have conducted extensive genetic investigations in recent years to unravel the intricate pathophysiology of AH.Methods: In this study, we conducted a comprehensive bibliometric analysis employing VOSviewer software to identify the most noteworthy genetic factors that have been the focal point of numerous investigations within the AH field in recent years. Our analysis revealed genes and microRNAs intricately linked to AH, underscoring their pivotal roles in this condition. Additionally, we performed molecular docking analyses to ascertain microRNAs with the highest binding affinity to these identified genes. Furthermore, we constructed a network to elucidate the in-silico-based functional interactions between the identified microRNAs and genes, shedding light on their potential roles in AH pathogenesis.Results: Notably, this pioneering in silico examination of genetic factors associated with AH promises novel insights into our understanding of this complex condition. Our findings prominently highlight miR-7110-5p, miR-7110-3p, miR-663, miR-328-3p, and miR-140-5p as microRNAs exhibiting a remarkable affinity for target genes. These microRNAs hold promise as valuable diagnostic and therapeutic factors, offering new avenues for the diagnosis and treatment of AH in the foreseeable future.Conclusion: In summary, this research underscores the critical importance of genetic factors in AH and, through in silico analyses, identifies specific microRNAs with significant potential for further investigation and clinical applications in AH management.

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Section: Discussionmentioning

confidence: 99%

Genetic and epigenetic factors of arterial hypertension: a bibliometric- and in-silico-based analyses

Karabaeva,

Vochshenkova,

Zare

et al. 2023

Front. Mol. Biosci.

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“…Many other diseases are also associated with C677T gene polymorphism of MTHFR . Such as cardiovascular diseases, diabetes, venous thrombosis ( 21 ) and breast cancer ( 22 ). Hyperhomocysteinemia is an emerging risk factor for various cardiovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

C677T Gene Polymorphism of MTHFR Is a Risk Factor for Impaired Renal Function in Pregnant Women With Preeclampsia in the Chinese Han Population

Lin

Ge²,

Xu³

et al. 2022

Front. Cardiovasc. Med.

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Impaired renal function in pregnant women with preeclampsia is particularly common, yet there is no consensus about implementation. This lack of consensus is due in part to uncertainty about risks for disease progression. Limited evidence suggests that C677T gene polymorphism of 5, 10-methylenetetrahydrofolate reductase (MTHFR C677T) may affect impaired renal function in pregnant women with preeclampsia in Chinese Han population. To investigate the association between MTHFR C677T and impaired renal function in pregnant women with preeclampsia, a total of 327 pregnant women diagnosed with gestational hypertension (GH) or preeclampsia-eclampsia (PE) from January 2016 to December 2021 were selected as the study subjects. The personal information, gestational information, clinical indicators, and the C677T gene polymorphism of MTHFR were tested. Compared with the GH group, the PE renal function impairment group had increased in blood pressure, homocysteine level, liver and kidney function indicators (creatinine, uric acid, urea nitrogen, cystatin C, alanine aminotransferase, aspartate aminotransferase, cholyglycine), and blood lipids (total cholesterol, triglycerides and low density lipoprotein) but had reductions in plasma protein (total protein, albumin, globulin, prealbumin), trace elements (calcium and zinc), prothrombin time and fibrinogen. The homocysteine level in the TT genotype was higher than that in the CC and CT genotypes. Binary logistic regression analysis showed that the MTHFR C677T gene polymorphism was associated with PE renal function impairment in the recessive model (OR: 1.620, 95% CI: 1.033–2.541, P < 0.05). These findings show that the C677T gene polymorphism of MTHFR is an independent risk factor for impaired renal function in pregnant Chinese Han women with PE.

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“…Особое внимание среди большого числа генов-кандидатов привлекают полиморфные варианты генов II (FII) и V (FV) факторов свертывания крови, гена, кодирующего метилентетрагидрофолатредуктазу (MTHFR) (особенно его однонуклеотидный полиморфизм С677T), ассоциированные с развитием ССЗ, которые могли являться ФР ОКС. Однако данные о роли полиморфизмов в генах FII, FV, MTHFR в развитии артериальной патологии противоречивы [6][7][8].…”

Section: Discussionunclassified

Thrombosis risk factors and gene mutations in young age patients with acute coronary syndrome

Ponomarenko

Сукманова

2019

Kardiologiia

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Goal of research. Study the role of thrombosis risk factors and polymorphisms in genes in young age patients with acute coronary syndrome (ACS).Materials and methods. Te study included 299 patients of age 25 to 44 years old with ACS were treated from 2012 to 2017 at the department of myocardial infarction 1st KGBUZ Altay regional cardiological clinic. Te middle age of patients with ACS was 40.3 ± 0.2 years. Te control group included of 53 apparently healthy volunteers aged from 25 to 44 years old, the average age those patients was 39.94 ± 0.79 years. Also, those patients hadn’t any comorbid conditions. Te control group hadn’t any datas of ischemic heart disease by the results of exercise tolerance tests. All patients had standard clinical, anamnestic, biochemical tests, lipid profle, fasting plasma glucose, electrocardiogram, echocardiography and coronaroangiography, also they were determined growth and weight with body-weight index. 116 patients from the ACS group and 53 patients fromthe control group had screening of polymerase chain reaction for determine polymorphism of the FII genes G20210-A, FV G1691-A, and MTHFR C677-T.Results. We identifed the most signifcant sets of risk factors associated with ACS in young age patients based on our multifactorial statistical analysis with binary logistic regression. Tis combination of risk factors was: increased levels of low-density lipoproteins, decreased levels of high-density lipoproteins, smoking, existence of MTHFR homozygous polymorphism, heredity in combination with smoking, FV homozygote, MTHFR homozygote, smoking with MTHFR-homozygote.Conclusion. Te ability predicting the risk of developing cardiovascular disease in young people based on traditional risk factors, partly modifable, as well as the researching of "new" risk factors, opens up new opportunities for developing a clinical approach of treating young patients with high risk of ACS.

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Methylenetetrahydrofolate Reductase Gene Polymorphism (C677T) as a Risk Factor for Arterial Thrombosis in Georgian Patients

Cited by 13 publications

References 23 publications

Genetic and epigenetic factors of arterial hypertension: a bibliometric- and in-silico-based analyses

Genetic and epigenetic factors of arterial hypertension: a bibliometric- and in-silico-based analyses

C677T Gene Polymorphism of MTHFR Is a Risk Factor for Impaired Renal Function in Pregnant Women With Preeclampsia in the Chinese Han Population

Thrombosis risk factors and gene mutations in young age patients with acute coronary syndrome

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