Methylprotodioscin from the Mexican medical plant Solanum rostratum (Solanaceae)

Bah, Moustapha; Gutiérrez, Dora M.; Escobedo, Carolina; Mendoza, Sandra; Rojas, J. Isela; Rojas, Antonio

doi:10.1016/s0305-1978(03)00172-8

Cited by 21 publications

(13 citation statements)

References 9 publications

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“…The monosaccharides obtained by acid hydrolysis of each compound were identified by comparison on TLC with authentic samples and GC analysis as D-glucose, L-rhamnose and Dxylose for 1; D-glucose and L-rhamnose for 2, 3, 4 and 6; Dglucose, D-galactose and L-rhamnose for 5. The known compounds 2-6 were identified by comparison of their spectral data with those reported in the literature as dioscin (2) [11], protodioscin (3) [11,12], methyl-protodioscin (4) [11,13], indioside D (5) [11,14], and solamargine (6) [11,15]. [16].…”

Section: Resultsmentioning

confidence: 99%

Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: Confirmation of their synonymy

et al. 2012

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Section: Resultsmentioning

confidence: 99%

Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: Confirmation of their synonymy

et al. 2012

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“…The S. rostratum ethanolic extract reduced the viability of the Hela cell line, and the damage was time-and dose-dependent (32). Some researchers have demonstrated important compounds present in S. rostratum, including methyl-protodioscin that was identified in the methanol-chloroform-extract of the aerial parts (33,34). Methyl-protodioscin is a bioactive natural compound that has numerous pharmacological activities, including those related to antiinflammatory and anticancer activities.…”

Section: Discussionmentioning

confidence: 99%

Assessments of Antioxidant Content and the Anti-Carcinogenic Effect of Extracts of Solanum Rostratum Dunal in Human Cancer Cells

Vega¹,

Izquierdo-Vega²,

Ibarra³

et al. 2019

Acta Poloniae Pharmaceutica - Drug Research

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Cancer includes a group of more than 100 different types of diseases characterized by the accelerated and disorderly growth of abnormal cells. Cancer is a major worldwide public health problem. According to the International Agency for Research on Cancer (IARC), cancer increased to 18.1 million new cases and 9.6 million cancer deaths in 2018 (1). Historically, natural products have been used since ancient times and in folklore for treatment of many diseases (2). Traditional medicine is known the sum total of the knowledge, skills, and practices based on the theories and experiences indigenous to different cultures used in the maintenance of health and for the prevention, diagnosis, improvement, and/or treatment of illness (3). Plants have comprised the basis of traditional medicine systems and their use by the peoples of many cultures has been widely documented. The World Health Organization has estimated that approximately 80% of the worldís inhabitants mainly employ traditional medicine for their primary healthcare (4). Currently, the use of medicinal plants to treat and prevent various types of cancer has experienced a breakthrough. Along with the cancer treatment ranging from surgery and radiation to chemotherapy or immunotherapy, millions of people seek additional options such as complementary and alternative medicine. In traditional Mexican folk medicine, Solanum rostratum has been used for years to treat kidney disorders, stomachache, and digestive disorders and with the use of the infusion of the leaves as a purgative. A tea prepared with the plantís flowers is rec

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“…Flavonoids and saponins are the most common isolated compounds which have been reported from the Chinese species S. Rostratum [20]. However, the phytochemical study of the Mexican medical plant S. rostratum Dun led to isolated one saponin (methyl protodioscin) [9]. S. rostratum species which grow in Azerbaidzhan was collected in the Stepanakert region, and two glycosidic alkaloid compounds were obtained and identified as solasonine and solamargine.…”

Section: Discussionmentioning

confidence: 99%

“…Solanum rostratum Dun is a harmful herb, it has widespread existence in North America [6] and has been classifying as quarantine weed for ecosystem and human health [7]. The previous isolation studies showed that S. rostratum had alkaloid components: Solasonine, solamargine [8], and methyl protodioscin [9], which cause the toxicity of this species [10]. In addition to exist the phenolic compounds which have various activities against antibacterial, cytotoxic and antioxidant [11,12].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Constituents and Antioxidant Effect of Solanum Rostratum Species From Algeria T

Tebboub

Noman

Mohamed

et al. 2018

Asian J Pharm Clin Res

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Objective: The aim of this study was to isolate the constituents and evaluate the antioxidant activity of Solanum rostratum Dunal (Solanaceae) from Algeria. Methods: In this study, phytochemical analyses of the chloroform, ethyl acetate, and n-butanol extracts obtained from the aerial parts of S. rostratum were performed by column chromatography, thin-layer chromatography, and high-performance liquid chromatography techniques. The antioxidant activity was performed by 2,2-diphenyl-1-picrylhydrazyl scavenging assay method.Results: The identification and structure elucidation of the isolated compounds were compared with their nuclear magnetic resonance spectra and the literature led to identify one monoterpene glycoside (linalyl-β-glucopyranoside) (1) and three flavonoid glycosides: Apigenin-7-O-glucoside (2), astragalin (3) and (isorhamnetin-3-O-glucoside (4).Conclusion: This is the first report on the isolation and structure elucidation of compound (1) (linalyl-β-glucopyranoside) and compound (2) (apigenin-7-O-glucoside) from this species. In addition, antioxidant effect of the chloroform extract from S. rostratum was evaluated. The chloroform extract exhibited the remarkable radical scavenging ability (IC50=0066±0.001 mg/mL).

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Methylprotodioscin from the Mexican medical plant Solanum rostratum (Solanaceae)

Cited by 21 publications

References 9 publications

Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: Confirmation of their synonymy

Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: Confirmation of their synonymy

Assessments of Antioxidant Content and the Anti-Carcinogenic Effect of Extracts of Solanum Rostratum Dunal in Human Cancer Cells

Phytochemical Constituents and Antioxidant Effect of Solanum Rostratum Species From Algeria T

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