This Special Issue invited researchers to contribute their original research work and review articles on “Symmetry and Fluid Mechanics” that either advances the state-of-the-art mathematical methods through theoretical or experimental studies or extends the bounds of existing methodologies with new contributions related to the symmetry, asymmetry, and lie symmetries of differential equations proposed as mathematical models in fluid mechanics, thereby addressing current challenges. In response to the call for papers, a total of 42 papers were submitted for possible publication. After comprehensive peer review, only 25 papers qualified for acceptance for final publication. The rest of the papers could not be accommodated. The submissions may have been technically correct but were not considered appropriate for the scope of this Special Issue. The authors are from geographically distributed countries such as the USA, Australia, China, Saudi Arabia, Iran, Pakistan, Malaysia, Abu Dhabi, UAE, South Africa, and Vietnam. This reflects the great impact of the proposed topic and the effective organization of the guest editorial team of this Special Issue.