mi<scp>RNA</scp>s at the interface of cellular stress and disease

Emde, Anna; Hornstein, Eran

doi:10.15252/embj.201488142

Cited by 105 publications

(90 citation statements)

References 138 publications

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“…This response is sometimes mediated by miRNA function through regulating the amount of miRNAs, the amount of mRNA targets, or the interaction of miRNA-protein complexes. Thus, clarifying miRNA-mediated regulatory networks would provide a novel insight into the genetic improvement of species stress tolerance [18,19]. Herein, we found that the role of miR-204 in hypoxia tolerance in tilapia.…”

Section: Discussionmentioning

confidence: 89%

miRNA-directed regulation of VEGF in tilapia under hypoxia condition

Zhao

Zhu

Yan

et al. 2014

Biochemical and Biophysical Research Communications

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Section: Discussionmentioning

confidence: 89%

miRNA-directed regulation of VEGF in tilapia under hypoxia condition

Zhao

Zhu

Yan

et al. 2014

Biochemical and Biophysical Research Communications

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“…A peripheral blood compartment that may be particularly relevant are the exosomes, cellular miRNAs-containing secretory vesicles able to attach recipient cells and release miRNAs potentially modulating their function [127]. Recent results clearly indicate that miRNAs are important mediators of stress responses and their deregulation has been implicated in a variety of stress-related neuropathological conditions [128,129]. Accordingly, UPR regulates the expression of many miRNAs that play an important role in the regulation of life and death decisions during ER stress [130].…”

Section: Intercellular Communication Mediated By Micrornasmentioning

confidence: 99%

The ups and downs of cellular stress: the “MAM hypothesis” for Bipolar disorder pathophysiology

Pereira¹,

Resende²,

Morais³

et al. 2017

IJCNMH

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Mental health problems constitute the largest single source of world economic burden, with an estimated global cost greater than cardiovascular disease, cancer or diabetes individually. In the European Union mental disorders affect millions of people and these numbers are expected to rise as result of Europe's ageing population. Given the biological causes of many of these disorders, most studies focus on their molecular basis. Bipolar disorder (BD) is characterized by mood swings between depression and mania resulting in cognitive and functional impairments that require lifetime treatment. Recurrent mood episodes, residual symptoms, functional impairment, psychosocial disability with high rates of divorce, unemployment, drug abuse and suicide attempting, and significant medical comorbidities such as metabolic and cardiovascular diseases cannot be efficiently controlled even with proper use of current treatments. Moreover, delayed diagnosis/misdiagnosis is frequent because reliable biomarkers are absent. Therefore, a better understanding of BD pathophysiology is a prerequisite for the design of new drugs and their implementation in clinical practice as well as to develop biomarkers for a more accurate and earlier diagnosis and/or evaluation of therapeutic response. This review summarises the association between decreased cellular resilience towards stress and BD. Since the key stress-response mediator Mitochondria-Associated Membranes (MAMs) modulate several BD relevant processes such as mitochondrial dysfunction and oxidative stress, Ca 2+ deregulation and cytoskeleton abnormalities, endoplasmic reticulum stress responses, loss of proteostasis and inflammasome activation, we propose the "MAM hypothesis" for BD pathophysiology. Targeting MAM-associated signaling pathways can be a promising investigation avenue to identify novel therapeutic strategies.Keywords: Bipolar disorder, Endoplasmic reticulum, Mitochondria, Mitochondria-associated membranes, Cellular resilience, Cellular stress, Plasticity. Bipolar DisorderBD is a chronic psychiatric illness with a remitting course, affecting 2.4% of the general population [1], characterized by mood swings between manic and depressive states that result in cognitive and functional impairments, high health care costs and premature mortality [2,3]. BD is the sixth leading cause of disability worldwide responsible for loss of more disability-adjusted life-years than all forms of cancer and major neurological conditions [4]. BD is associated with greatly impaired quality of life and increased physical health burden [5]. Moreover, BD patients tend to have high rates of divorce, unemployment, drug abuse and crime as consequence of impaired social cognition, and its impact on patients can be devastating, with approximately 23% of patients with BD reported having suicide attempts [6]. Moreover, individuals with BD diagnosis have a high risk of medical comorbidities such as metabolic (diabetes, obesity and metabolic syndrome) and cardiovascular disorders [7].Current knowl...

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“…miRNAS regulate mRNA expression by either inducing mRNA degradation or translational repression (Emde & Hornstein, 2014;SmithVikos & Slack, 2012). First discovered in C. elegans, miRNAs have become another important set of molecular regulators, as their appropriate or aberrant function has been implicated in the regulation of stem cell selfrenewal, cell proliferation, stress response, metabolism, apoptosis, among others cellular processes (Abe & Bonini, 2012;Emde & Hornstein, 2014;Jung & Suh, 2012). Hence, it is not surprising that extensive research has identified aberrant mRNA regulation in neurodegeneration and aging (Abe & Bonini, 2012;Szafranski, Abraham, & Mekhail, 2015).…”

Section: Mirnas In Longevity Health and Diseasementioning

confidence: 99%