Micellar liquid chromatography retention model based on mass-action concept of micelle formation

Loginova, Lidia P.; Samokhina, Larisa V.; Boichenko, Alexander P.; Kulikov, A. Yu.

doi:10.1016/j.chroma.2005.11.135

Cited by 28 publications

(13 citation statements)

References 28 publications

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“…(3) that combines Eqs. (1) and (2) [2,20,25] (The parameters of Eq. (3), correlation coefficients between predicted and experimental values and cross-validated correlation coefficients calculated by leave-one-out method are listed in Table 1 in Supplementary materials):…”

Section: Organic Modifiers and Selectivitymentioning

confidence: 99%

“…Both the micelle concentration and the amount of organic modifier influence the selectivity and elution strength in MLC [2,19,25]. Thus, a chemometric investigation of the effects of these two parameters is needed to reveal the full separation capability of the method [48].…”

Section: Solute Hydrophobicity and Retentionmentioning

confidence: 99%

“…This is due to the pseudophase character of the micellar mobile phase, comprising a polar aqueous phase and a less polar micellar phase, and dynamically modified by surfactant monomers and modifier molecules stationary phase that results in weaker hydrophobic interactions in MLC [2]. The elution strength in MLC is estimated by the slopes b or b of the retention equations [2,19,25,46,47]:…”

Section: Comparison Of Elution Strength Of Hybrid Mobile Phases Modifmentioning

confidence: 99%

“…Several empirical and mechanical retention models have been proposed to take into account the presence of modifiers in micellar mobile phases [22][23][24][25]. The models allowed to develop optimization procedures which can be used to find quickly the best surfactant concentration and modifier proportion in a micellar mobile phase that will give the optimal resolution in a particular situation [26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Aliphatic carboxylic acids and alcohols as efficiency and elution strength enhancers in micellar liquid chromatography

Boichenko

Berthod

2010

Journal of Chromatography A

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Section: Organic Modifiers and Selectivitymentioning

confidence: 99%

Section: Solute Hydrophobicity and Retentionmentioning

confidence: 99%

Section: Comparison Of Elution Strength Of Hybrid Mobile Phases Modifmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Aliphatic carboxylic acids and alcohols as efficiency and elution strength enhancers in micellar liquid chromatography

Boichenko

Berthod

2010

Journal of Chromatography A

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“…In MLC, several empirical or mechanistic retention models have been developed which describe the retention behavior. In any case, the models allow a reliable optimization of the separation conditions based on a reduced number of experiments [21][22][23][24][25]. In this study, the performance of the several hyperbolic and logarithmic empirical retention models, fitted with the retention data of five aromatic diamines (Fig.…”

Section: Introductionmentioning

confidence: 97%

Evaluation of Some Empirical Retention Models for High Submicellar Liquid Chromatographic Separation of Aromatic Diamines

Hadjmohammadi¹,

Nazari²

2015

Acta Chromatographica

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Summary. Description of the retention of five aromatic diamines in high submicellar liquid chromatography was carried out through several hyperbolic and logarithmic retention models using the retention data of mobile phases consisting of sodium dodecyl sulfate (SDS) (0.09-0.15 M) and methanol (50-70% v/v) at pH 3. Among the investigated models, the logarithmic retention modelshowed the best prediction capability and used to predict the solutes retention factors. The mean relative error of the prediction of retention factors of five aromatic diamines in the selected variables space was lower than 0.5%. Based on the best retention model, a grid search program was used to predict the retention times of each solute for all combinations of SDS and methanol concentrations in the factor space. In order to find optimal separation condition, two different chromatographic goals, analysis time and retention differences between adjacent peaks, were evaluated simultaneously using Derringer's desirability function for each mobile phase composition. At the optimal conditions (0.143 M SDS, 53% v/v methanol), a good agreement was observed between predicted and experimental values of the retention times (R 2 = 0.9999 and mean relative error of 0.96%).

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Micellar and aqueous‐organic liquid chromatography using sub‐2 μm packings for fast separation of natural phenolic compounds

Cao

Cheng

2010

J of Separation Science

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The objective of the present work was to investigate the chromatographic behavior of natural phenolic compounds in micellar and aqueous-organic LC using a short column packed with 1.8 microm particles. Firstly, the effect of ACN and SDS on elution strength and selectivity was examined by isocratic submicellar (0-30% ACN/5% 1-butanol/1-6 mM SDS) and micellar (0-30% ACN/5% 1-butanol/40-60 mM SDS) systems. The varied concentrations of two modifiers in the mobile phases revealed different eluting power. Then, the application of organic modifier gradient was discussed in both submicellar and micellar LC using mobile phases of 4 mM SDS/5% 1-butanol or 50 mM SDS/5% 1-butanol containing ACN gradient from 0 to 30%, respectively. For micellar system, the separation was found to be better in gradient than isocratic elution. Additionally, the sensitivity of aqueous-organic LC was examined. The mobile phase was a mixture of ACN and water employing gradient elution at a flow rate of 0.5 mL/min, with analysis time below 9 min. It was found that separation efficiency was significantly better compared with micellar LC. Besides, the aqueous-organic LC has been applied to separation of various phenolic compounds in Yangwei granule or Radix Astragali samples.

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Micellar liquid chromatography retention model based on mass-action concept of micelle formation

Cited by 28 publications

References 28 publications

Aliphatic carboxylic acids and alcohols as efficiency and elution strength enhancers in micellar liquid chromatography

Aliphatic carboxylic acids and alcohols as efficiency and elution strength enhancers in micellar liquid chromatography

Evaluation of Some Empirical Retention Models for High Submicellar Liquid Chromatographic Separation of Aromatic Diamines

Micellar and aqueous‐organic liquid chromatography using sub‐2 μm packings for fast separation of natural phenolic compounds

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