Micelle formation by some phenothiazine derivatives. II. Nuclear magnetic resonance studies in deuterium oxide

Micellar Properties of Drugs: Properties of Micellar Aggregates of Phenothiazines and Their Aqueous Solutions

“…the values agreeing well with those obtained from pH and NMR data (2). The effective micellar change, p , was estimated from the conductance data using an equation proposed by Evans (18):…”

“…In 0.154 M NaCI, thioridazine micelles contain 57 monomers at 34"; pH measurements in water as a function of drug concentration a t 20 and 34" show abrupt changes a t the CMC and even more abrupt changes in the presence of sodium chloride (2). This behavior points to there being a true micellization phenomenon.…”

“…The aggregation of four phenothiazines (chlorpromazine, promazine, promethazine, and thioridazine) was previously studied by NMR techniques (1,2). Measurements of the changes in chemical shift produced in solutions of the four compounds by varying their concentration above and below their critical micelle concentration (CMC) allowed calculation of the proportion of monomer and micelles present in solution.…”

“…Materials-The phenothiazines used were described previously (2). A commercial sample of triflupromazine was used as received.…”

A comparative study of the thermodynamic properties at the air–water interface and in the bulk of structurally related phenothiazine drugs aqueous solutions

“…The phenothiazine drugs, although possessing tricyclic planar ring systems aggregate following a micellar association pattern [12,13]. NMR studies [17,18] suggest the stacking of molecules within the aggregate in the manner of the tricyclic dyes. Although some workers [19] have referred to this inflection point as the critical micelle concentration (cmc), there is evidence from e.m.f.…”