Micelles assembled with carbocyanine dyes for theranostic near-infrared fluorescent cancer imaging and photothermal therapy

Dually pH/Reduction-Responsive Vesicles for Ultrahigh-Contrast Fluorescence Imaging and Thermo-Chemotherapy-Synergized Tumor Ablation

“…34,47 To demonstrate the imaging capacity of Vesicles, we evaluated their in vivo NIRF imaging on the mice bearing 4T1 tumors. 28,30 Free ICG/DOX and Micelles had low NIRF signals at tumor and quick elimination of signals at tumors afterwards during 4 days ( Figure 6A and 6B). 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 9.5-fold increases of signals as compared to those of Micelles ( Figure 6B).…”

“…[27][28][29][30][31][32][33] Moreover, the nanocarriers such as micelles are found to achieve synergistic thermochemotherapy or thermo-photodynamic therapy owing to their sustained releases, preferable tumor accumulation, and enhanced drug translocation from lysosomes to cytoplasm upon coencapsulation with anticancer compounds such as doxorubicin and chlorin e6. 27,30 However, the design of the existing theranostic nanocarriers such as micelles is mainly limited in several aspects: first, detectable NIRF signals at tumors are generally diminished quickly owing to easy degradation and elimination of cyanine dyes in physiological environment (e.g.…”

Efficient cancer ablation by combined photothermal and enhanced chemo-therapy based on carbon nanoparticles/doxorubicin@SiO 2 nanocomposites

“…PTT can be applied selectively and locally at cancer sites while not affecting normal tissues, and therefore is a noninvasive and safe strategy in cancer therapy. Light sensitizers, such as noble metals, carbon materials and organic polymers and molecules, are often used to enhance the light absorption and thus improve the PTT efficacy [8][9][10][11][12][13][14][15][16][17][18]. Although previous studies demonstrate that with the help of the above light sensitive materials PTT is efficient in cancer therapy, single PTT cannot always eradicate cancers completely, leading to cancer recurrence [19].…”

Recent advances in the development of organic photothermal nano-agents

“…Combined photothermal and photodynamic therapy under the guidance of multimodal imaging was realized in this work, demonstrating remarkable synergistic in inhibiting tumor growth [50]. Similar strategies have also been proposed by several other groups in their recent studies [51][52][53][54].…”