Miconazole in Paracoccidioidomycosis

Stevens, David A.; Restrepo-M., Angela

doi:10.1016/s0140-6736(79)92267-0

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“…Miconazole was inhibitory for most isolates at concentrations of 2-4 pgl ml. These may represent therapeutically achievable serum levels [8,9]. Most isolates of A. jumigatus were resistant to R34,000 at concentrations of less than 16 pg/ml.…”

Section: Discussionmentioning

confidence: 99%

<i>In vitro</i> Comparison of the Antifungal Activities of R34,000, Miconazole and Amphotericin B

Dm¹,

Ge²,

Shadomy³

et al. 1978

Chemotherapy

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In vitro susceptibilities of 78 isolates of pathogenic filamentous fungi to the imidazole compounds R34,000 and miconazole and to amphotericin B were determined using an agar dilution technique. Allescheria boydii, Sporothrix schenckii and the dematiaceous fungi (Cladosporium, Fonsecaea and Phialophora spp.) were most susceptible to miconazole with minimum inhibitory concentration (MIC) values ranging from ≤ 0.25 to 32 µg/ml and with geometric mean MIC (G-MIC) values of 0.56–1.24 µg/ml. Isolates of Aspergillus jumigatus were more susceptible to amphotericin B and miconazole than to R34,000 with G-MIC values of 1.20 and 3.48 µg/ml, respectively. Coccidioides immitis, Histoplasma capsulatum and Blastomyces dermatitidis were highly susceptible to all three drugs (G-MICs < 1 µg/ml); R34,000 was the most active of the three compounds against C. immitis (G-MIC = 0.44 µg/ml).

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Section: Discussionmentioning

confidence: 99%