Micro and nanoencapsulation of bioactive compounds for agri-food applications: A review

Guía-García, Jorge L.; Charles-Rodríguez, Ana V.; Reyes-Valdés, M. Humberto; Ramírez-Godina, Francisca; Robledo‐Olivo, Armando; García-Osuna, Hermila T.; Cerqueira, Miguel A.; Flores-López, María L.

doi:10.1016/j.indcrop.2022.115198

Cited by 31 publications

(17 citation statements)

References 106 publications

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“…Nevertheless, their use in food products is still problematic due to their intense aroma, bitter taste, poor thermal stability, low oxidative stability, and insolubility in water [ 9 ]. Thus, the nanoencapsulation technique of bioactive compounds is an interesting strategy for the solution to these drawbacks since it could mask their bitter taste and increase the protection of their medicinal properties [ 10 , 11 , 12 ]. It is known that antioxidants reduce oxidative stress and therefore prevent the onset of degenerative diseases caused by free radicals, so the use of nanoparticles would enhance these benefits [ 13 ] and would also improve the bioavailability of the antioxidants present in the natural propolis studied, which could be included in medicines and preferably in functional foods [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Obtaining and Characterizing Andean Multi-Floral Propolis Nanoencapsulates in Polymeric Matrices

Ligarda-Samanez

Choque-Quispe

Moscoso-Moscoso

et al. 2022

Foods

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Propolis is a substance with significant anti-inflammatory, anticancer, and antiviral activity, which could be used more efficiently at the nano level as an additive in the food industry. The aim was to obtain and characterize nanoencapsulated multi-floral propolis from the agro-ecological region of Apurimac, Peru. For nanoencapsulation, 5% ethanolic extracts propolis with 0.3% gum arabic and 30% maltodextrin were prepared. Then, the mixtures were dried by nano spraying at 120 °C using the smallest nebulizer. The flavonoid content was between 1.81 and 6.66 mg quercetin/g, the phenolic compounds were between 1.76 and 6.13 mg GAE/g, and a high antioxidant capacity was observed. The results of moisture, water activity, bulk density, color, hygroscopicity, solubility, yield, and encapsulation efficiency were typical of the nano spray drying process. The total organic carbon content was around 24%, heterogeneous spherical particles were observed at nanometer level (between 11.1 and 562.6 nm), with different behaviors in colloidal solution, the thermal gravimetric properties were similar in all the encapsulates, the FTIR and EDS analysis confirmed the encapsulation and the X-ray diffraction showed amorphous characteristics in the obtained material; stability and phenolic compound release studies indicated high values of 8.25–12.50 mg GAE/g between 8 and 12 h, the principal component analysis confirmed that the flora, altitude, and climate of the propolis location influenced the content of bioactive compounds, antioxidant capacity, and other properties studied. The nanoencapsulate from the district of Huancaray was the one with the best results, allowing its future use as a natural ingredient in functional foods. Nevertheless, technological, sensory, and economic studies should still be carried out.

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Section: Introductionmentioning

confidence: 99%

Obtaining and Characterizing Andean Multi-Floral Propolis Nanoencapsulates in Polymeric Matrices

Ligarda-Samanez

Choque-Quispe

Moscoso-Moscoso

et al. 2022

Foods

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“…In the scientific literature, bioactive compounds (BCs) are described as a natural compound capable of interacting with one or more components of living tissues and exerting a variety of effects [48,49]. In addition, the distinctions between the definitions of dietary supplements, nutraceuticals, and functional foods are sometimes misinterpreted.…”

Section: Bioactive Compounds From Agro-wastementioning

confidence: 99%

“…Additionally, they have antibacterial potential due to the production of many antibiotics by microbes produced through agricultural waste. Numerous studies have been conducted on the bioactive compounds found in agricultural residues [49,53]. From the results of orange and lemon processing, millions of tons of waste are generated annually from the industrial manufacture of orange and lemon juice, and this waste is a rich source of hydroxycinnamic acids and flavonoids, primarily flavanone glycosides, flavanones, and flavone aglycons [79].…”

Section: Antibacterial and Anticancer Propertiesmentioning

confidence: 99%

Transformation of Agro-Waste into Value-Added Bioproducts and Bioactive Compounds: Micro/Nano Formulations and Application in the Agri-Food-Pharma Sector

et al. 2023

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The agricultural sector generates a significant amount of waste, the majority of which is not productively used and is becoming a danger to both world health and the environment. Because of the promising relevance of agro-residues in the agri-food-pharma sectors, various bioproducts and novel biologically active molecules are produced through valorization techniques. Valorization of agro-wastes involves physical, chemical, and biological, including green, pretreatment methods. Bioactives and bioproducts development from agro-wastes has been widely researched in recent years. Nanocapsules are now used to increase the efficacy of bioactive molecules in food applications. This review addresses various agri-waste valorization methods, value-added bioproducts, the recovery of bioactive compounds, and their uses. Moreover, it also covers the present status of bioactive micro- and nanoencapsulation strategies and their applications.

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“…Encapsulation is described as a process where a core material (a liquid, solid or gaseous compound) is packaged in a wall material to create capsules that are effective against chemical and environmental interactions [ 20 , 21 ]. Encapsulation is an alternative for problems of physical or chemical instability of compounds.…”

Section: Polymers Used For Encapsulation Of Bioactive Compoundsmentioning

confidence: 99%

Encapsulation of Bioactive Compounds for Food and Agricultural Applications

et al. 2022

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This review presents an updated scenario of findings and evolutions of encapsulation of bioactive compounds for food and agricultural applications. Many polymers have been reported as encapsulated agents, such as sodium alginate, gum Arabic, chitosan, cellulose and carboxymethylcellulose, pectin, Shellac, xanthan gum, zein, pullulan, maltodextrin, whey protein, galactomannan, modified starch, polycaprolactone, and sodium caseinate. The main encapsulation methods investigated in the study include both physical and chemical ones, such as freeze-drying, spray-drying, extrusion, coacervation, complexation, and supercritical anti-solvent drying. Consequently, in the food area, bioactive peptides, vitamins, essential oils, caffeine, plant extracts, fatty acids, flavonoids, carotenoids, and terpenes are the main compounds encapsulated. In the agricultural area, essential oils, lipids, phytotoxins, medicines, vaccines, hemoglobin, and microbial metabolites are the main compounds encapsulated. Most scientific investigations have one or more objectives, such as to improve the stability of formulated systems, increase the release time, retain and protect active properties, reduce lipid oxidation, maintain organoleptic properties, and present bioactivities even in extreme thermal, radiation, and pH conditions. Considering the increasing worldwide interest for biomolecules in modern and sustainable agriculture, encapsulation can be efficient for the formulation of biofungicides, biopesticides, bioherbicides, and biofertilizers. With this review, it is inferred that the current scenario indicates evolutions in the production methods by increasing the scales and the techno-economic feasibilities. The Technology Readiness Level (TRL) for most of the encapsulation methods is going beyond TRL 6, in which the knowledge gathered allows for having a functional prototype or a representative model of the encapsulation technologies presented in this review.

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Micro and nanoencapsulation of bioactive compounds for agri-food applications: A review

Cited by 31 publications

References 106 publications

Obtaining and Characterizing Andean Multi-Floral Propolis Nanoencapsulates in Polymeric Matrices

Obtaining and Characterizing Andean Multi-Floral Propolis Nanoencapsulates in Polymeric Matrices

Transformation of Agro-Waste into Value-Added Bioproducts and Bioactive Compounds: Micro/Nano Formulations and Application in the Agri-Food-Pharma Sector

Encapsulation of Bioactive Compounds for Food and Agricultural Applications

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