A new generation of versatile microcantilever sensors with tailorable nanoporous metal-organic frameworks (MOFs) has been successfully demonstrated. Two metal-organic frameworks (MOFs), HKUST-1 and MOF-508 were characterized to demonstrate new stress-induced sensing mechanism. The microcantilever sensors were fabricated on silicon-on-insulator (SOI) wafers with 1 µm thickness of the final beam. The results exhibited extraordinary sensitivity, and a selective reversible response for chemical detection (1). Metal-organic frameworks (MOFs) are attracting attention as the ideal material for sensing applications because of their nanoporosity, ultrahigh surface area, and the fact that they can be tailored for adsorption of specific analytes (1). In this work, HKUST-1 was prepared and characterized to demonstrate that different MOFs can detect multiple analytes with microcantilever array (2). The elastic properties of MOFs were measured by nanoindentation test (MTS Nano-Indentor XP) and Raman microscope (Renishaw) was used to characterize coated MOFs-thin films on gold compared with MOFs powders.