Micro/nano materials regulate cell morphology and intercellular communication by extracellular vesicles

Liu, Mengya; Wang, Dan; Gu, Shuangying; Tian, Baoxiang; Liang, Jiaqi; Suo, Qian; Zhang, Zhijun; Yang, Guo‐Yuan; Zhou, Yue; Li, Song

doi:10.1016/j.actbio.2021.02.003

Cited by 11 publications

(5 citation statements)

References 45 publications

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“…Accumulating evidence suggested that the morphology and size of nanomaterials play a critical role in cell behaviors, including adhesion, viability, proliferation, migration, functionalization or differentiation ( Nguyen et al, 2016 ; Zhou et al, 2018 ; Li et al, 2020 ; Liu M. et al, 2021 ; Wang et al, 2021b ; Yang et al, 2021 ; Yao et al, 2021 ). Figure 2A shows that the nanosized HA particles possessed uniform distribution and needle-shaped morphology.…”

Section: Resultsmentioning

confidence: 99%

Regulation of T Cell Responses by Nano-Hydroxyapatite to Mediate the Osteogenesis

Guo

Yuan

Huang

et al. 2022

Front. Bioeng. Biotechnol.

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Nano-hydroxyapatite (nHA) has been widely applied as a tissue-engineering biomaterial and interacted with osteoblasts/stem cells to repair bone defects. In addition, T cells that coexist with osteoblasts/stem cells in the bone modulate the regulation of osteoimmunology by cytokine formation. However, the effects of nHA on T cells and the following regulatory interplay on osteogenic differentiation have been rarely examined. In this work, the physicochemical properties of needle-like nHA are characterized by field emission scanning electron microscopy, zeta potential, Fourier transform-infrared and X-ray diffraction. It is found that as the concentration of nHA increases, the proliferation of T cells gradually increases, and the proportion of apoptotic T cells decreases. The percentage of CD4+ T cells is higher than that of CD8+ T cells under the regulation of needle-like nHA. Furthermore, the supernatant of T cells co-cultured with nHA significantly inhibits the osteogenic differentiation of MC3T3-E1 by downregulating the formation of alkaline phosphatase and calcium nodule compared with the supernatant of nHA. Thus, our findings provide new insight into the nHA-mediated T cell and osteoblast interactions.

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Section: Resultsmentioning

confidence: 99%

Regulation of T Cell Responses by Nano-Hydroxyapatite to Mediate the Osteogenesis

Guo

Yuan

Huang

et al. 2022

Front. Bioeng. Biotechnol.

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“…Especially the surface with micro/nanogrooves can generally enhance endothelial cell alignment and migration along the groove direction. [92][93][94] However, most of the studies on surface topography were performed in 2D substances. It should be noted that cells are actually living in a 3D microenvironment in vivo.…”

Section: The Micro/nano-morphology Of Pore Surfacementioning

confidence: 99%

Vascularization in tissue engineering: The architecture cues of pores in scaffolds

Xia

Luo

2021

J Biomed Mater Res

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Vascularization is a key event and also still a challenge in tissue engineering. Many efforts have been devoted to the development of vascularization based on cells, growth factors, and porous scaffolds in the past decades. Among these efforts, the architecture features of pores in scaffolds played important roles for vascularization, which have attracted increasing attention. It has been known that the open macro pores in scaffolds could facilitate cell migration, nutrient, and oxygen diffusion, which then could promote new tissue formation and vascularization. The pore parameters are the important factors affecting cells response and vessel formation. Thus, this review will give an overview of the current advances in the effects of pore parameters on vascularization in tissue engineering, mainly including pore size, interconnectivity, pore size distribution, pore shape (channel structure), and the micro/nano-surface topography of pores.

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“…Wan et al developed a one-step nEV isolation platform which included a nanostructures with sEV size-matched silica and a surface-conjugated lipid nanoprobe, and this platform can improve the cancer diagnosis [ 46 ]. Liu et al showed that Micro/nano materials regulate endothelial cells morphology and transferred sEV to smooth muscle cells and regulate their phenotype [ 47 ]. However, the ability of topographic signals to regulate the sEV function of hMSC has not yet been reported.…”

Section: Resultsmentioning

confidence: 99%

Small extracellular vesicles with nanomorphology memory promote osteogenesis

Liao

et al. 2022

Bioactive Materials

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Micro/nano materials regulate cell morphology and intercellular communication by extracellular vesicles

Cited by 11 publications

References 45 publications

Regulation of T Cell Responses by Nano-Hydroxyapatite to Mediate the Osteogenesis

Regulation of T Cell Responses by Nano-Hydroxyapatite to Mediate the Osteogenesis

Vascularization in tissue engineering: The architecture cues of pores in scaffolds

Small extracellular vesicles with nanomorphology memory promote osteogenesis

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