Micro RNA-146a But Not IRAK1 is Associated with Rheumatoid Arthritis in the Tunisian Population

Hassine, Habib; Boumiza, Asma; Sghiri, Rim; Baccouche, K.; Boussaid, Imen; Atig, Ahlem; Shakoor, Zahid; Bouajina, E.; Zemni, Ramzi

doi:10.1089/gtmb.2016.0270

Cited by 22 publications

(20 citation statements)

References 36 publications

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“…Recently, a study conducted on Tunisian population reveals a correlation of miR-146a and rheumatoid arthritis (RA), indicating that miR-146a might play a protective role in RA pathogenesis, which is mediated by plentiful pro-inflammatory cytokines through NF-kB pathways. [ 34 ] In addition, miR-146a expression in serum was illuminated to be negatively associated with the levels of TNF-α, IL-6, IL-8, and LTE-4 in AECOPD patients, and that miR-146a was negatively correlated with TNF-α, IL-6, IL-1β, IL-8, and LTE-4 levels in COPD patients in our study. The probable explanation of the correlation of miR-146a with those inflammatory cytokines may be that miR-146a is involved in the modulation of those cytokines expression.…”

Section: Discussionmentioning

confidence: 49%

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Circulating miR-146a/b correlates with inflammatory cytokines in COPD and could predict the risk of acute exacerbation COPD

Chen

Gao

2018

Medicine

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The aim of this study was to investigate the predicting value of miR-146a/b for acute exacerbation chronic obstructive pulmonary disease (AECOPD) and COPD, and to explore their associations with inflammatory cytokines in AECOPD and stable COPD patients.One hundred six AECOPD, 122 stable COPD patients, and 110 health volunteers with age and sex matched to total COPD patients (AECOPD and stable COPD) were enrolled. Blood samples were collected from all participants. Relative expression of miR-146a/b was determined by real-time polymerase chain reaction. Tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), leukotriene B4 (LTB-4) expression in serum from AECOPD and stable COPD patients were assessed using commercial ELISA kit.Serum levels of miR-146a and miR-146b were down regulated in AECOPD patients compared with stable COPD patients and HCs. miR-146a and miR-146b are of good values for predicting the risk of AECOPD in HCs with AUC of 0.702 and 0.715. Additionally, miR-146a and miR-146b could distinguish AECOPD from stable COPD patients with AUC of 0.670 and 0.643. In AECOPD patients, levels of miR-146a in AECOPD patients were negatively associated with TNF-α, IL-6, IL-8, and LTE-4 expression. In stable COPD patients, miR-146a expressions were negatively correlated with TNF-α, IL-1β, IL-6, IL-8, and LTE-4 levels. And, the expressions of miR-146b in AECOPD patients were negatively associated with IL-1β and LTB-4 expression. While in stable COPD patients, miR-146b expressions were only negatively correlated with TNF-α level.In conclusion, miR-146a and miR-146b were negatively correlated with inflammatory cytokines, and could be promising biomarkers for predicting the risk of AECOPD in stable COPD patients and healthy individuals.

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Section: Discussionmentioning

confidence: 49%

“…It might result from that the mechanisms of miR-146a/b mediating the levels of inflammatory cytokines reported by previous studies. [ 31 , 32 , 34 – 36 , 38 , 40 – 42 , 46 – 51 ]…”

Section: Discussionmentioning

confidence: 99%

Circulating miR-146a/b correlates with inflammatory cytokines in COPD and could predict the risk of acute exacerbation COPD

Chen

Gao

2018

Medicine

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“…Molecular epidemiological studies showed robust evidence that the presence of these genetic polymorphisms would be associated with a variety of diseases, such as inflammatory bowel [18], systemic lupus erythematosus (SLE) [19], some cancers [20] and RA [21,22]. Recently, studies assessing miR-146a rs2910164 or miR-499 rs3746444 polymorphism and risk of RA have been published [23–25], but the results are not always consistent. And other studies add to the evidence base of the associations of other miRNA polymorphism with arthritis risk but are not limited to RA – but not exclusively – the amount and impact of inflammation [24,26].…”

Section: Introductionmentioning

confidence: 99%

Association of microRNAs genes polymorphisms with arthritis: a systematic review and meta-analysis

et al. 2019

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Objective: To investigate whether microRNAs genes’ polymorphisms are associated with arthritis. Methods: The PubMed, Cochrane Library et al. were systematically searched to identify case–control studies, systematic reviews and meta-analyses. A meta-analysis was performed to calculate odds ratios (ORs), and confidence intervals (CIs) at 95% using fixed-effect model or random-effects model. Results: Twenty-two case–control studies involving 10489 participants fulfilled the inclusion criteria. MiR-146a rs2910164 (G/C) was not significantly associated with the risk of rheumatoid arthritis (RA) in any model. Significant associations were found between miR-146a rs2910164 (G/C) and the risk of psoriatic arthritis (PsA) in the heterozygous model and the dominant model. The heterozygous model showed a significant association between the miR-146a rs2910164 (G/C) polymorphism and ankylosing spondylitis (AS). And there was no significant association of miR-146a rs2910164 (G/C) with risk of juvenile rheumatoid arthritis (JRA) at any model. Additionally, there was a significant association of miR-499 rs3746444 (T/C) with risk of RA at two genetic models, and with a moderate heterogeneity. When subgroup analysis by ethnicity, significant associations were almost found between miR-499 rs3746444 (T/C) and the risk of RA in any model in Caucasian populations, and there is no heterogeneity. Conclusions: The association of miR-146a rs2910164 (G/C) with RA was not found. And there was a significant association between miR-146a rs2910164(G/C) and PsA or AS. MiR-499 rs3746444 (T/C) was associated with RA in Caucasian populations. These findings did not support the genetic association between miR-146a rs2910164 (G/C) and JRA susceptibility, as well as the association of miR-196a-2 rs11614913 (C/T), miR-146a rs2431697, miR-146a rs57095329, miR-149 rs22928323 with arthritis.

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“…The results of the systematic search and selection performed according to the inclusion and exclusion criteria are shown in Figure 1 . A total of 13 articles with 2660 cases and 4098 controls were finally included in the meta-analysis ( Chatzikyriakidou et al, 2010 ; Yang et al, 2011 , 2016 ; Jimenez-Morales et al, 2012 ; El-Shal et al, 2013 ; Hashemi et al, 2013 ; Zhang et al, 2013 ; Zhou X. et al, 2015 ; Bogunia-Kubik et al, 2016 ; Ciccacci et al, 2016 ; Toraih et al, 2016 ; Fattah et al, 2017 ; Hassine et al, 2017 ). The 13 articles comprised 16 studies, including 9 studies on miR-146a rs2910164 and 7 studies on miR-499 rs3746444.…”

Section: Resultsmentioning

confidence: 99%

“…A single nucleotide polymorphism consisting of the G/C nucleotide substitution in miR-146a rs2910164 could result in the replacement of a G:U pair by a C:U mismatch ( Hassine et al, 2017 ). However, the association between mir146a polymorphisms and RA remains controversial.…”

Section: Discussionmentioning

confidence: 99%

An Updated Meta-Analysis of the Associations Between MicroRNA Polymorphisms and Susceptibility to Rheumatoid Arthritis

et al. 2018

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Aims: Rheumatoid arthritis (RA) is characterized by cartilage and bone damage leading to disability. Here, the association between microRNA (miRNA) polymorphisms and susceptibility to RA was evaluated by performing an updated meta-analysis and systematic review.Main methods: An electronic search of databases including PubMed and Embase was performed from inception to December 8, 2017 to retrieve studies investigating the association between miRNA polymorphisms and RA risk. Two reviewers independently screened literature according to the inclusion and exclusion criteria and extracted data. The meta-analysis was conducted using Stata 14.0 software.Key findings: Thirteen case-control studies with 2660 cases and 4098 controls were screened out after a systematic search. One study from the miR-146a rs2910164 G > C polymorphism group and two from the miR-499 rs3746444 T > C polymorphism group were excluded because of deviations from Hardy-Weinberg equilibrium. Pooled analysis demonstrated that miR-146a rs2910164 G > C polymorphism was not significantly associated with susceptibility to RA. However, a significant association was observed between miR-499 rs3746444 T > C polymorphism and RA risk (C vs. T: OR = 1.22, 95% CI = 1.05–1.42, P = 0.008; TC vs. TT: OR = 1.26, 95% CI = 1.05–1.50, P = 0.011; TC/CC vs. TT: OR = 1.26, 95% CI = 1.07–1.5, P = 0.007). Subgroup analysis based on ethnicity showed no significant association between miR-499 T > C polymorphism and susceptibility to RA in the Asian population (P > 0.05). However, in Caucasian population, the C allele in the miR-499 T > C polymorphism was a contributor to RA susceptibility in some genetic models (C vs. T: OR = 1.64, 95% CI = 1.28–2.11, P < 0.001; TC vs. TT: OR = 1.95, 95% CI = 1.40–2.71, P < 0.001; TC/CC vs. TT: OR = 1.96, 95% CI = 1.43–2.69, P < 0.001).Significance: The miR-146a rs2910164 G > C polymorphism was not associated with susceptibility to RA. In the Caucasian population, the C allele in the miR-499 T > C polymorphism contributed to RA susceptibility.

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Micro RNA-146a But Not IRAK1 is Associated with Rheumatoid Arthritis in the Tunisian Population

Abstract: The IRAK1 rs3027898 was not associated with RA, whereas C allele of miR-146a rs2910164 was found to be protective. Functional studies are required to investigate the exact role of miR-146a rs2910164 during RA.

Cited by 22 publications

References 36 publications

Circulating miR-146a/b correlates with inflammatory cytokines in COPD and could predict the risk of acute exacerbation COPD

Circulating miR-146a/b correlates with inflammatory cytokines in COPD and could predict the risk of acute exacerbation COPD

Association of microRNAs genes polymorphisms with arthritis: a systematic review and meta-analysis

An Updated Meta-Analysis of the Associations Between MicroRNA Polymorphisms and Susceptibility to Rheumatoid Arthritis

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