Micro total analysis system (�-TAS) in biotechnology

Abstract

Nanobiotechnology raises fascinating possibilities for new analytical assays in various fields such as bioelectronic assembly, biomechanics and sampling techniques, as well as in chips or micromachined devices. Recently, nanotechnology has greatly impacted biotechnological research with its potential applications in smart devices that can operate at the level of molecular manipulation. Micro total analysis system (micro-TAS) offers the potential for highly efficient, simultaneous analysis of a large number of biologically important molecules in genomic, proteomic and metabolic studies. This review aims to describe the present state-of-the-art of microsystems for use in biotechnological research, medicine and diagnostics.

Effects of Micromachining Processes on Electro-Osmotic Flow Mobility of Glass Surfaces

“…Because there are many beneficial size effects at the micro and nano scales, such as short mixing times, high efficiency in chemical reactions, and minute amounts of reagents and effluent liquids, micro/nano fluidic devices have been extensively studied for use in biomedical applications [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. In particular, nano fluidic devices that contain nano channels can be used for separation and filtration [21], single-molecule detection [22][23][24][25][26], highly efficient PCR [27], chemical analysis [28,29] and nano-photonic sensors [30], with great help of development of nanofabrication technologies [31][32][33][34][35][36][37][38][39][40][41][42][43].…”

Clinical Chemistry: Challenges for Analytical Chemistry and the Nanosciences from Medicine

“…The expression m-TAS was coined in 1990 by scientists at Ciba-Geigy AG. [185] It refers to measuring devices in which all the necessary steps for the chemical analysis of a substance are carried out automatically (for example, separations, filtrations, dilutions, and evaluations).…”

Real-time detection of influenza A virus using semiconductor nanophotonics

“…2 However, the delocalization of arbitrary biochemical analyses is still a challenge today, where nanotechnogy could present solutions for the development of micro total analysis systems (mTAS) potentially capable of portable biodiagnostics. 3 We present here the results of an effort towards such a solution through a wholly integrated semiconductor-based surface plasmon resonance (SPR) nanometric platform.…”

“…Thus, while SPR instruments are commercially available, their daily use remains confined within specific research fields for both industry and academia. The cross-hybridization of SPR technology with other diagnostic platforms, as would be fundamentally required by any mTAS, 3 has thus far been relatively impractical.…”

“…2 However, the delocalization of arbitrary biochemical analyses is still a challenge today, where nanotechnogy could present solutions for the development of micro total analysis systems (mTAS) potentially capable of portable biodiagnostics. 3 We present here the results of an effort towards such a solution through a wholly integrated semiconductor-based surface plasmon resonance (SPR) nanometric platform.SPR is a well-established optical phenomenon where an electromagnetic (EM) beam of a specific energy and incident wavevector (angle) can induce a resonant group oscillation within the surface electrons of a metal-dielectric interface. 4 The resulting EM field is evanescent in nature, with typical confinement of 200 nm for visible light.…”