Micro Total Analysis Systems: Fundamental Advances and Applications

Analysis of Long-term Morphological Changes of Micro-patterned Molecules and Cells on PDMS and Glass Surfaces

“…Shun-ichi FUNANO, Nobuyuki TANAKA, and Yo TANAKA † Quantitative Biology Center (QBiC), RIKEN,[1][2][3] Suita, Japan We demonstrated that our previously developed gas-phase fluoroalkylsilane patterning method was applicable to polydimethylsiloxane (PDMS) and we compared the stability of patterned proteins and cultured cells between PDMS and glass surfaces. The shapes of the protein patterns were stable on both glass and PDMS surfaces for more than 1 week.…”

“…Exploiting these advantages, a number of researchers have developed novel methods to use microdevices for chemical and biochemical analyses and syntheses. [1][2][3] From the viewpoint of microchip materials, most researchers have used polydimethylsiloxane (PDMS) microchips because their fabrication is easy and cost is low. However, PDMS is not always appropriate for chemical operations, because its chemical and physical stabilities are insufficient.…”

Fast and Single-step Fluorescence-based Competitive Bioassay Microdevice Combined PDMS Microchannel Arrays Separately Immobilizing Graphene Oxide-Analyte Conjugates and Fluorescently-labelled Receptor Proteins

“…[1][2][3][4] Recently, a large number of studies on technological developments of microsystems, microchemistry, and fully automated analytical systems have been reported in attempts to solve these problems. [5][6][7][8] However, simultaneously solving these problems is still challenging. Recently, we proposed designing "singlestep" microdevices based on square glass capillaries [9][10][11][12][13] or polymer capillaries.…”

Design and characterization of a passive, disposable wireless AC-electroosmotic lab-on-a-film for particle and fluid manipulation

“…During recent decades, lab-on-a-chip (LOC) technology, which deals mostly with precise manipulation of micro/nano-scale liquid and/or biological particles, has made considerable progress in the development of micro/nano-systems for chemical, biological, and medical applications [1,2]. Of the various LOC devices which have followed many are based on electrical methods, including electrophoresis (EP) [3,4] electrowetting on dielectric (EWOD) [5,6] and electrokinetics effects (including dielectrophoresis (DEP) [7][8][9][10] AC electroosmosis (ACEO) [11][12][13][14] and the electrothermal effect [15,16]).…”