Microbial fuel cell-based self-powered biosensing platform for determination of ketamine as an anesthesia drug in clinical serum samples

Asghary, Maryam; Raoof, Jahan Bakhsh; Rahimnejad, Mostafa; Ojani, Reza

doi:10.1007/s13738-017-1245-3

Cited by 15 publications

(13 citation statements)

References 34 publications

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“…As an rapid and cost-effective analytical tool, aptamer biosensor (aptasensor) has attracted increasing attention for determination of illicit drugs, such as cocaine, methamphetamine, codeine and ketamine (Asghary et al, 2018;Lodha et al, 2014;Mao et al, 2018;Mokhtarzadeh et al, 2015;Roncancio et al, 2014). The signal of sensors from the binding between DNA aptamers and illicit drugs can be detected with colorimetry (Li et al, 2013), fluorescence (Stojanovic et al, 2000) and Surface-Enhanced Raman Spectrometry (SERS) (Mao et al, 2018), electrochemistry , and other techniques (Neves et al, 2015;Ya et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Rapid duplexed detection of illicit drugs in wastewater using gold nanoparticle conjugated aptamer sensors

Mao

Jun-hai

et al. 2019

Science of The Total Environment

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The abuse of illicit drug addiction is a worldwide public health and social problem. In this paper, we reported on a simple and rapid colorimetric biosensor for duplexed detection of methamphetamine (METH) and cocaine in a single assay. Gold nanoparticles (AuNPs) and Au@Ag NPs were synthesized and functionalized with DNA reporter probes (RPs) for METH and cocaine, respectively. The magnetic beads (MBs) were conjugated with two capture probes (CPs) respective to METH and cocaine. The respective RPs and CPs were designed to hybridize with each illicit drug-binding DNA aptamers through DNA-DNA hybridization, forming a sandwich structure. This MBs-based sandwich structure could be removed with an external magnetic field. However, due to the higher affinity of DNA aptamers with illicit drugs, the sandwich structure was disassembled when illicit drugs are introduced into the solution, leading to the colour changes of the supernatant. Utilizing a non-negative matrix factorization (NMF) algorithm to process the data, we demonstrated the ability

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Section: Introductionmentioning

confidence: 99%

Rapid duplexed detection of illicit drugs in wastewater using gold nanoparticle conjugated aptamer sensors

Mao

Jun-hai

et al. 2019

Science of The Total Environment

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“…Electrochemical sensors are the most suitable portable devices for continuous real-time monitoring; Fuel cell sensors offer simplicity, high accuracy, and portability. 32 Electrochemistry for sensing.-Electrochemistry is an effective method for VOC detection. The technique is based on the principle of redox reactions.…”

Section: Theory Of Pemfc For Voc Sensingmentioning

confidence: 99%

Review—Micro-Fuel Cell Principal Biosensors for Monitoring Transdermal Volatile Organic Compounds in Humans

et al. 2022

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Knowledge of transduction mechanisms in biosensing applications paves the way for ultrasensitive and dynamic detection in living systems. Real-world biosensing applications where ultrasensitivity and dynamic detection are paramount include monitoring the anesthetic agent concentration during surgery; the slightest variation in concentration can potentially result in a life-threatening overdose or, on the other end of the spectrum, the patient's awareness during the procedure. We review the benefits and functions of the transcutaneous biosensor device compared with other current technology and discuss the sensor's capability to accurately measure volatile anesthetic gas concentration in blood using fuel cell technology. We review fundamental concepts of fuel-cell technology for bio-sensing applications. The fuel cell sensor can also continuously monitor other volatile organic compounds making it versatile with numerous potential applications.

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“…[ 54 ] They commonly use oxidoreductases, enzymes, organelles, or microorganisms as catalysts to aid the generation of electrical energy. Depending on the involved type of catalyst, the biofuel cells are classified as microbial fuel cells (micro‐organisms as catalyst), [ 55 ] enzymatic biofuel cells (enzymes as catalyst), [ 14 ] organelle biofuel cells (organelles as catalyst), [ 56 ] or photocatalytic fuel cells (semiconductor photocatalyst). [ 57 ] In this review, we focus on enzymatic biofuel cells due to the vast interest and their applicability, particularly in the field of biomedical engineering, arising from their ability to generate higher power densities and response solely using liquid samples based on specific catalytic effects.…”

Section: Working Principle Of Electrochemical Systems For Self‐powere...mentioning

confidence: 99%

Engineering Self‐Powered Electrochemical Sensors Using Analyzed Liquid Sample as the Sole Energy Source

Sailapu

Menon

2022

Advanced Science

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Many healthcare and environmental monitoring devices use electrochemical techniques to detect and quantify analytes. With sensors progressively becoming smaller—particularly in point‐of‐care (POC) devices and wearable platforms—it creates the opportunity to operate them using less energy than their predecessors. In fact, they may require so little power that can be extracted from the analyzed fluids themselves, for example, blood or sweat in case of physiological sensors and sources like river water in the case of environmental monitoring. Self‐powered electrochemical sensors (SPES) can generate a response by utilizing the available chemical species in the analyzed liquid sample. Though SPESs generate relatively low power, capable devices can be engineered by combining suitable reactions, miniaturized cell designs, and effective sensing approaches for deciphering analyte information. This review details various such sensing and engineering approaches adopted in different categories of SPES systems that solely use the power available in liquid sample for their operation. Specifically, the categories discussed in this review cover enzyme‐based systems, battery‐based systems, and ion‐selective electrode‐based systems. The review details the benefits and drawbacks with these approaches, as well as prospects of and challenges to accomplishing them.

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Microbial fuel cell-based self-powered biosensing platform for determination of ketamine as an anesthesia drug in clinical serum samples

Cited by 15 publications

References 34 publications

Rapid duplexed detection of illicit drugs in wastewater using gold nanoparticle conjugated aptamer sensors

Rapid duplexed detection of illicit drugs in wastewater using gold nanoparticle conjugated aptamer sensors

Review—Micro-Fuel Cell Principal Biosensors for Monitoring Transdermal Volatile Organic Compounds in Humans

Engineering Self‐Powered Electrochemical Sensors Using Analyzed Liquid Sample as the Sole Energy Source

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