Microbiology and Cytokine Levels Around Healthy Dental Implants and Teeth

Nowzari, Hessam; Botero, Javier Enrique; deGiacomo, Marina; Villacres, Maria C.; Rich, Sandra K.

doi:10.1111/j.1708-8208.2007.00076.x

Cited by 71 publications

(84 citation statements)

References 32 publications

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“…Further, TNF-α levels around miniscrew implants were higher than those around the teeth during the baseline period in our study, although the increase was not significant. This finding is consistent with the results reported by Nowzari et al 30 In the present study, cytokine levels around the miniscrews and canines increased in the initial periods. We attribute these increases to an acute response against the forces applied at the beginning of distalization.…”

Section: Discussionsupporting

confidence: 83%

Identification of tumor necrosis factor-α levels around miniscrews during canine distalization

et al. 2011

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Objective: The aim of this study was to measure tumor necrosis factor-α (TNF-α) levels around miniscrews used for anchorage during a 3-month period of canine distalization. Methods: Sixteen patients (8 boys, 8 girls; mean age, 16.6 ± 2.4 years) whose upper first premolars were extracted for orthodontic treatment were included in this study. Miniscrews were used as an anchorage unit in canine distalization. Thirty-two (32) miniscrew implants were placed bilaterally in the alveolar bone between the maxillary second premolars and first molars. The treatment, miniscrew, and control groups comprised upper canines, miniscrew implants, and upper first premolars, respectively. Peri-miniscrew implant crevicular fluid and gingival crevicular fluid were obtained before applying force and at 1, 24, and 48 hours, and at 7 and 21 days, and 3 months after applying force. Results: During the 3-month period, the TNF-α levels increased significantly at 24 hours only in the treatment group (p ＜ 0.01). In the miniscrew and control groups, there were no statistically significant changes. No significant differences were observed between groups. Conclusions: Miniscrews can be conveniently used for anchorage in orthodontics.

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Section: Discussionsupporting

confidence: 83%

Identification of tumor necrosis factor-α levels around miniscrews during canine distalization

et al. 2011

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“…However, the microbial burden could not fully correspond to peri-implant disease severity. AGNB have been detected in previous studies both in peri-implantitis cases (Botero et al 2005;Alcoforado et al 1991;Leonhardt et al 1999;Rosenberg et al 1991), as well as in healthy implants (Nowzari et al 2008b;Leonhardt et al 1999;Nowzari et al 2008a). Thus, the true role of AGNB in the etiology of peri-implant infections remains unclear.…”

Section: Pseudomonas Auruginosa Acinetobacter Baumannii)mentioning

confidence: 97%

Peri-Implant Infections of Oral Biofilm Etiology

Belibasakis

Charalampakis

Bostancı

et al. 2014

Advances in Experimental Medicine and Biology

108

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Biofilms are complex microbial communities that grow on various surfaces in nature. The oral micobiota tend to form polymicrobial biofilms, particularly on the hard mineralized surfaces of teeth, which may impact on oral health and disease. They can cause inflammation of the adjacent tooth-supporting (periodontal) tissues, leading to destructive periodontal disease and tooth loss. The emergence of osseointegrated dental implants as a restorative treatment option for replacing missing teeth has also brought along new artificial surfaces within the oral cavity, on which oral bacteria can form biofilms. As in the case of natural teeth, biofilms on implant surfaces may also trigger infection and cause inflammatory destruction of the peri-implant tissue (i.e. peri-implantitis). While there are strong similarities in the composition of the mixed microbial flora between periodontal and peri-implant infections, there are also a few distinctive differences. The immunological events underlying the pathogenesis of peri-implant infections are qualitatively similar, yet more extensive, compared to periodontal infections, resulting in a faster progression of tissue destruction. This chapter summarizes the current knowledge on the microbiology and immunology of peri-implant infections, including findings from the peri-implant crevicular fluid, the inflammatory exudate of the peri-implant tissue. Moreover, it discusses the diagnosis and current approaches for the treatment of oral infections.

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“…They concluded that such polymorphism does not constitute a genetic risk factor for early implant loss. Nowzari et al (6) in turn studied cytokine and �acterial levels �etween teeth and dental implants in healthy su�-jects. An increased cytokine presence was noted in patients with dental implants (two-fold in the case of IL-8).…”

Section: Influence Of Interleukins 6 8 10 and 12 Upon Periimplant Imentioning

confidence: 99%

“…The increase in cytokine concentration in the crevicular fluid of dental implants may lead to a lack of osteointegration, �one loss or implant failure (5)(6)(7). Bone is a dynamic tissue continuously su�ject to remodeling through rea�sorption and formation, these processes �eing controlled �y the local production of cytokines, among other factors (4).…”

Section: Influence Of Interleukins 6 8 10 and 12 Upon Periimplant Imentioning

confidence: 99%