Microbiota y diabetes mellitus tipo 2

Muñoz-Garach, Araceli; Diaz-Perdigones, Cristina; Tinahones, Francisco J.

doi:10.1016/j.endonu.2016.07.008

Cited by 109 publications

(52 citation statements)

References 80 publications

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“…Butyrate can induce differentiation of Treg cells in vitro and in vivo , and ameliorated the development of colitis. These observations suggest that butyrate may have a role in host–microbe interactions establish immunological homeostasis in the gut and thus, influence pathobiology of type 2 DM [82] , [157] , [158] , [159] , [160] , [161] , [162] , [163] , [164] , [165] . In addition, obesity and type 2 DM are associated with hypothalamic inflammation due to enhanced production of TNF-α that explains the involvement of brain in these conditions including changes in the concentrations of various neurotransmitters [82] , [102] .…”

Section: Cytokines Gut Microbiota Pufas and Type 2 Dmmentioning

confidence: 86%

“…Like the involvement of gut microbiota in type 1 DM, there is a strong relationship between gut microbiota and type 2 DM. Some of the mechanisms that relate gut microbiota to the onset of insulin resistance and type 2 DM include: changes in bowel permeability, endotoxemia, interaction with bile acids, changes in the proportion of brown adipose tissue, and effects associated to use of drugs like metformin [82] , [157] , [158] , [159] , [160] , [161] , [162] . The role of gut microbiota in type 2 DM can, in part, be attributed to their ability to produce acetate, propionate and butyrate that have anti-inflammatory actions.…”

Section: Cytokines Gut Microbiota Pufas and Type 2 Dmmentioning

confidence: 99%

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Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review

Das¹

2018

Journal of Advanced Research

101

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Section: Cytokines Gut Microbiota Pufas and Type 2 Dmmentioning

confidence: 86%

Section: Cytokines Gut Microbiota Pufas and Type 2 Dmmentioning

confidence: 99%

Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review

Das¹

2018

Journal of Advanced Research

101

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“…The past decade of research has proven that this complex microbial community inhabiting our digestive tract, mainly colon, has numerous roles, such as absorption and metabolism of compounds, and development of immune response, and this large impact on host physiology and metabolism makes it important influencer in terms of human health. Scientific evidence within the area is accumulating, and so far, gut microbiota composition has been related to the risk of obesity [54], type 2 diabetes [55], cardiovascular diseases [56,57], immunological diseases [58], inflammatory bowel disease [59], and gastrointestinal cancer [60].…”

Section: The Gut Microbiota As a Predictor Of Responsiveness To A Heamentioning

confidence: 99%

Biomarkers of a Healthy Nordic Diet—From Dietary Exposure Biomarkers to Microbiota Signatures in the Metabolome

Landberg

Hanhineva

2019

Nutrients

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Whole diets and dietary patterns are increasingly highlighted in modern nutrition and health research instead of single food items or nutrients alone. The Healthy Nordic Diet is a dietary pattern typically associated with beneficial health outcomes in observational studies, but results from randomized controlled trials are mixed. Dietary assessment is one of the greatest challenges in observational studies and compliance is a major challenge in dietary interventions. During the last decade, research has shown the great importance of the gut microbiota in health and disease. Studies have have both shown that the Nordic diet affects the gut microbiota and that the gut microbiota predicts the effects of such a diet. Rapid technique developments in the area of high-throughput mass spectrometry have enabled the large-scale use of metabolomics both as an objective measurement of dietary intake as well as in providing the final readout of the endogenous metabolic processes and the impact of the gut microbiota. In this review, we give an update on the current status on biomarkers that reflect a Healthy Nordic Diet or individual components thereof (food intake biomarkers), biomarkers that show the effects of a Healthy Nordic Diet and biomarkers reflecting the role of a Healthy Nordic Diet on the gut microbiota as well as how the gut microbiota or derived molecules may be used to predict the effects of a Healthy Nordic Diet on different outcomes.

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“…Fatness is affected by many factors, such as genetics, nutrition, and lifestyle as well as gut microbiome. More and more studies in humans have shown that obesity is related to the gut microbiota (Ley et al, 2006; Turnbaugh et al, 2009; Munoz-Garach et al, 2016). …”

Section: Introductionmentioning

confidence: 99%

Evaluating the Contribution of Gut Microbiota to the Variation of Porcine Fatness with the Cecum and Fecal Samples

Fang

Huang

et al. 2016

Front. Microbiol.

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Microbial community in gastrointestinal tract participates in the development of the obesity as well as quite a few metabolic diseases in human. However, there are few studies about the relationship between gut microbiota and porcine fatness. Here, we used high-throughput sequencing to perform 16S rRNA gene analysis in 256 cecum luminal samples from Erhualian pigs and 244 stools from Bamaxiang pigs, and adopted a two-part model statistical method to evaluate the association of gut microbes with porcine fatness. As the results, we identified a total of 6 and 108 operational taxonomic units (OTUs), and 9 and 10 bacterial taxa which showed significant associations with fatness traits in the stool and cecum samples, respectively. Cross-validation analysis indicated that gut microbiome showed the largest effect on abdominal adipose by explaining 2.73% phenotypic variance of abdominal fat weight. Significantly more fatness-associated OTUs were identified in the cecum samples than that in the stools, suggesting that cecum luminal samples were better used for identification of fatness-associated microbes than stools. The fatness-associated OTUs were mainly annotated to Lachnospiraceae, Ruminococcaceae, Prevotella, Treponema, and Bacteroides. These microbes have been reported to produce short-chain fatty acids by fermenting dietary indigested polysaccharide and pectin. The short-chain fatty acids can regulate host body energy homeostasis, protect host from inflammation and inhibit fat mass development. Our findings suggested that the gut microbiome may be an important factor modulating fatness in pigs.

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Microbiota y diabetes mellitus tipo 2

Cited by 109 publications

References 80 publications

Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review

Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review

Biomarkers of a Healthy Nordic Diet—From Dietary Exposure Biomarkers to Microbiota Signatures in the Metabolome

Evaluating the Contribution of Gut Microbiota to the Variation of Porcine Fatness with the Cecum and Fecal Samples

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