Microcystic Adnexal Carcinoma: A Case Showing Eccrine Duct Differentiation

Ceballos, Patricia I.; Penneys, Neal S.; Cohen, Bernard

doi:10.1111/j.1524-4725.1988.tb03480.x

Cited by 31 publications

(20 citation statements)

References 17 publications

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“…However, studies investigating the utility of immunohistochemistry in the diagnosis of microcystic adnexal carcinoma are few and restricted both in the spectrum of lesions and antibodies studied (Table 1). [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] Thus, even though immunohistochemical comparisons of microcystic adnexal carcinoma vs infiltrative basal cell carcinoma and desmoplastic trichoepithelioma exist in the published literature, they are confined to a single stain; and to date, only two studies employing a panel of immunohistochemical stains are performed. 17,19,21,23,24,26 In addition, a comparative study of microcystic adnexal carcinoma with squamous cell carcinoma particularly squamous cell carcinoma with ductal differentiation has not, to our knowledge, been reported previously.…”

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confidence: 99%

Microcystic adnexal carcinoma: an immunohistochemical reappraisal

Hoang

Dresser

Kapur³

et al. 2008

Modern Pathology

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Even though immunohistochemical comparisons of microcystic adnexal carcinoma vs infiltrative basal cell carcinoma and desmoplastic trichoepithelioma exist, they are mostly restricted to the use of a single stain. In addition, a comparison with squamous cell carcinoma has not been reported previously. In this study, we compare the expression of cytokeratin (CK) 15, CK7, CK20, CK903, carcinoembryonic antigen (CEA), CD10, CD15 and BerEP4 in 13 microcystic adnexal carcinoma, eight desmoplastic trichoepithelioma, 10 infiltrative basal cell carcinoma, and eight squamous cell carcinoma of which five exhibited ductal differentiation. We found that the majority of microcystic adnexal carcinoma (92%) and desmoplastic trichoepithelioma (100%) cases expressed CK15 while the infiltrative basal cell carcinoma and squamous cell carcinoma cases were all negative. Forty percent of infiltrative basal cell carcinoma expressed CK7; while only two microcystic adnexal carcinoma cases (15%) and one squamous cell carcinoma with ductal differentiation (12%) expressed CK7 in the remaining three tumor categories. None of the desmoplastic trichoepithelioma expressed CK7. All tumors were strongly positive for CK903. While the neoplastic cells were negative, luminal staining of ductal structures was noted for CK7, CD15 and CEA in some of the microcystic adnexal carcinoma, desmoplastic trichoepithelioma and squamous cell carcinoma with ductal differentiation cases. Sixty percent of infiltrative basal cell carcinoma, 31% of microcystic adnexal carcinoma, and 25% of squamous cell carcinoma express CD10. BerEP4 expression was noted in 38% of microcystic adnexal carcinoma, 57% of desmoplastic trichoepithelioma, 100% of infiltrative basal cell carcinoma, and 38% of squamous cell carcinoma. In conclusion, we found CK15 to be a useful marker in distinguishing microcystic adnexal carcinoma from infiltrative basal cell carcinoma and squamous cell carcinoma with ductal differentiation. Our experience indicates that microcystic adnexal carcinoma and desmoplastic trichoepithelioma have a similar immunohistochemical profile that is, CK15 þ and BerEP4 þ /À; thus, additional studies are needed to separate these two entities.

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confidence: 99%

Microcystic adnexal carcinoma: an immunohistochemical reappraisal

Hoang

Dresser

Kapur³

et al. 2008

Modern Pathology

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“…Some tail‐like appendages of the nests and ducts resemble tadpole formations seen in syringoma 3,4,13 . Both components are present in variable proportions, but some cases display only one 11,23,24 . Peri‐ and intraneural invasion is a common and characteristic finding 3,6 .…”

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confidence: 96%

Microcystic Adnexal Carcinoma: An Uncommon Tumor with Debatable Origin

et al. 2001

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“…Controversies are centered on the histogenesis of MAC; it has been reported that MAC shows follicular differentia tion [3], sweat gland differentiation [2][3][4]. or dual differen tiation [1,6,7], We used antibodies against CEA, S-100 protein.…”

Section: Discussionmentioning

confidence: 99%

“…Histo genesis of MAC has caused much controversy, since sev eral studies using microscopic, immunohistochemical or electron-microscopic techniques have revealed that MAC exhibits sweat gland differentiation [2][3][4], pilar differentia tion [5] or both [1.6, 7|. Only a few immunohistochemical examinations using antibodies against hard keratins or cytokeratins have been performed [8,9).…”

Section: Introductionmentioning

confidence: 99%