Microelectrode study of projections from the amygdaloid complex to the nucleus accumbens in the cat

Ito, Noboru; Ishida, Hisashi; Miyakawa, Fumio; Naito, Haruhiko

doi:10.1016/0006-8993(74)90285-6

Cited by 26 publications

(8 citation statements)

References 7 publications

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“…Basolateral amygdala inactivation reduced both the discriminative stimulus- and non-discriminative stimulus-induced excitation of ipsilateral NAc core neurons, consistent with the proposed BLA–NAc flow of information. Accordingly and replicating reviewed electrophysiological findings (Ito et al, 1974; Powell et al, 1968; Sato, 1977; Yim and Mogenson, 1982), electrical stimulation of the BLA rapidly excited 16% of ipsilateral NAc neurons. More compelling, BLA-evoked NAc neurons in the ipsilateral hemisphere were disproportionately the same ones that were excited by the discriminative stimulus, and most of these had monosynaptic-like BLA-evoked latencies (4–20 ms; Ambroggi et al, 2008).…”

Section: Functional Significance Of Amygdala–ventrostriatal Pathwayssupporting

confidence: 52%

“…In the years since Dr. Nauta’s survey, others substantiated the existence of direct amygdalostriatal pathways, including anatomical (Cowan et al, 1965; De Olmos and Ingram, 1972; Ishikawa et al, 1969; Knook, 1966; Krettek and Price, 1978) and electrophysiological (Gloor, 1955a; Ito et al, 1974; Powell et al, 1968; Sato, 1977) evidence of an amygdaloid projection to the NAc via the stria terminalis. These studies, including those enabled by the recently developed tract-tracing methods of anterograde transport of tritiated amino acids (Krettek and Price, 1978) and retrograde labeling (Groenewegen et al, 1980; Newman and Winans, 1980), supported the hypothesis that amygdala projections to the ventral striatum, including the ventral putamen, NAc, and olfactory tubercle, arise from the BLA and basomedial amygdala (BMA).…”

Section: Identification Of Amygdalostriatal Projectionsmentioning

confidence: 99%

“…While Kelley and colleagues’ paper demonstrated that basal amygdala nuclei project to what had, until then, been considered “non-limbic” caudal striatum, it was also influential for further characterizing the already known connection from the amygdala to the rostral ventral striatum (Cowan et al, 1965; De Olmos and Ingram, 1972; Gloor, 1955a; Groenewegen et al, 1980; Ishikawa et al, 1969; Ito et al, 1974; Knook, 1966; Krettek and Price, 1978; Nauta, 1961; Newman and Winans, 1980; Powell et al, 1968; Yim and Mogenson, 1982). In what would become a defining theme of Dr. Kelley’s research career, it squarely placed the NAc as an interface between the limbic system and the extrapyramidal motor systems to which it connected (Mogenson et al, 1980), including the globus pallidus, substantia nigra, and subthalamic nucleus.…”

Section: Amygdalo-ventrostriatal Projections: Focus On the Nucleusmentioning

confidence: 99%

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Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley

Zorrilla

Koob

2013

Neuroscience & Biobehavioral Reviews

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In MacLean’s triune brain, the amygdala putatively subserves motivated behavior by modulating the “reptilian” basal ganglia. Accordingly, Ann Kelley, with Domesick and Nauta, influentially showed that amygdalostriatal projections are much more extensive than were appreciated. Caudal of the anterior commissure, the entire striatum receives afferents from deep basal nuclei of the amygdala. They highlighted that amygdalar projections to the rostral ventromedial striatum converged with projections from the ventral tegmental area and cingulate cortex, forming a “limbic striatum”. Orthologous topographic projections subsequently were observed in fish, amphibians, and reptiles. Subsequent functional studies linked acquired value to action via this neuroanatomical substrate. From Dr. Kelley’s work evolved insights into components of the distributed, interconnected network that subserves motivated behavior, including the nucleus accumbens shell and core and the striatal-like extended amygdala macrostructure. These heuristic frameworks provide a neuroanatomical basis for adaptively translating motivation into behavior. The ancient amygdala-to-striatum pathways remain a current functional thread not only for stimulus–response valuation, but also for the psychopathological plasticity that underlies addictionrelated memory, craving and relapse.

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Section: Functional Significance Of Amygdala–ventrostriatal Pathwayssupporting

confidence: 52%

Section: Identification Of Amygdalostriatal Projectionsmentioning

confidence: 99%

Section: Amygdalo-ventrostriatal Projections: Focus On the Nucleusmentioning

confidence: 99%

See 1 more Smart Citation

Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley

Zorrilla

Koob

2013

Neuroscience & Biobehavioral Reviews

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“…This conclusion is consistent with the pattern of amygdala to NAS projection recently described using retrograde transport of wheat germ agglutinin (Phillipson and Griffiths, 1985). Amygdala stimulation-evoked spikes have been recorded previously in the rat (Yim and Mogenson, 1982), in the cat (Ito et al, 1974) and following stimulation of the stria terminalis in the rabbit (DeFrance et al, 1980). However, these past electrophysiological studies did not assess the topographical distribution of NAS cell responsiveness.…”

Section: Discussionmentioning

confidence: 95%

Distribution of amygdala input to the nucleus accumbens septi: An electrophysiological investigation

Callaway

Hakan

Henriksen

1991

J. Neural Transmission

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The nucleus accumbens septi (NAS) receives afferent input from the amygdala via the stria terminalis and from the hippocampus via the fimbria. Extracellular recordings from 196 NAS neurons in halothane-anesthetized rats revealed heterogeneous response patterns following stimulation of the amygdala. The observation that 30% of anterior NAS units but only 16% of posterior NAS units were responsive to amygdala stimulation suggested a topographical arrangement of amygdala efferents. Comparing the effects of amygdala and fimbria stimulation revealed that the two afferent pathways converge onto individual NAS neurons, but that the two sites of stimulation can differentially influence other neurons. The present results clarify the topographical distribution of amygdala input to the NAS, confirm that inputs from two limbic structures are integrated within the NAS, and further illustrate the electrophysiological heterogeneity of NAS neurons.

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“…Similar to other striatal tissue, many of the efferent fibers terminate in the diencephalon or the pallidal complex, with projections reaching the stria terminalis, preoptic region, nucleus parataenialis, nucleus mediodorsalis thalami, lateral habenular nucleus, substantia nigra-ventral tegmental area, the lateral hypothalamus, cingulum, thalamus, globus pallidus, and subpallidal region [9,17,75,105,106,107,108,109]. There also appear to be projections to the amygdala [110,111] and septum [9,112,113,114], although this is not a universal finding [19] (fig. 1b).…”

Section: Efferentsmentioning

confidence: 99%

The Nucleus Accumbens: A Comprehensive Review

Salgado

Kaplitt²

2015

Stereotact Funct Neurosurg

398

289

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There is increasing interest among functional neurosurgeons in the potential for novel therapies to impact upon diseases beyond movement disorders and pain. A target of increasing interest is the nucleus accumbens (NAc), which has long been studied as a key brain region mediating a variety of behaviors, including reward and satisfaction. As such, focal modulation of the biology of the NAc with deep brain stimulation or novel biological therapies such as gene therapy or cell transplantation could have a major impact upon disorders such as depression and drug addiction. In order to both develop appropriate therapies and then deliver them in an effective fashion, a thorough understanding of the biology, physiology, and anatomy of the NAc is critical. Here, we review the existing literature regarding several areas critical to the development of new therapies, including the known pharmacology, physiology, and connectivity of the NAc, as well as evidence supporting the potential for various NAc surgical therapies in animal models. We then review the relevant anatomy of the NAc, with particular attention to the surgical anatomy, imaging, and targeting necessary to facilitate a proper localization and delivery of new agents to this region. The NAc is a fascinating and potentially rich target for stereotactic neurosurgical intervention, and analysis of existing information regarding all aspects of this structure should help potentiate therapeutic advances and reduce complications from future studies of neurosurgical intervention in this region for a variety of disorders.

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Microelectrode study of projections from the amygdaloid complex to the nucleus accumbens in the cat

Cited by 26 publications

References 7 publications

Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley

Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley

Distribution of amygdala input to the nucleus accumbens septi: An electrophysiological investigation

The Nucleus Accumbens: A Comprehensive Review

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