Microemulsion as drug and gene delivery vehicle: an inside story

Development of Metronidazole Loaded Chitosan Nanoparticles Using QbD Approach—A Novel and Potential Antibacterial Formulation

“…[ 7 ]. Many strategies have been employed for targeting drugs in the colon milieu including: (a) a layer of pH-dependent polymer(s) that dissolve at pH equal to or higher than 7; (b) design of pulsatile and sustained release dosage forms [ 8 ]; and (c) the application of materials that might be digested entirely by the colonic bacteria [ 9 ].…”

Phase Behavior of Non‐Ionic Surfactant‐Medium Chain Triglyceride‐Water Microemulsion Systems

“…In a study of microemulsion drug delivery formulations developed between 2011 and 2016, Callender et al (2017) found that almost 90% of microemulsion formulations were comprised of non‐ionics, 7% were comprised of amphoterics, and 3% were comprised of ionics. More recently, similar findings of preferential use of non‐ionics such as Polysorbate 20, Polysorbate 80, Span 80, and pegylated hydrogenated castor oils in microemulsions (Rajpoot and Tekade, 2020) (Paliwal et al, 2019) and pegylated glycerides and medium chain monoglycerides in nanoemulsions (Changediya et al, 2019) have been reported. Microemulsion formation has traditionally been directed by the Bancroft rule and hydrophilic–lipophilic balance (HLB).…”

“…TPD and pTPD are of enormous importance in deducing the various types of microemulsions that may be obtained with certain surfactant/co‐surfactant, oil, and water concentrations. Previous research has primarily focused on spontaneous emulsification or phase titration methods as documented by Rajpoot and Tekade (2020), Patel et al (2017), and Talegaonkar et al (2016). Though useful, these oil‐ and water‐titration methods result in a narrow region of microemulsion formation within a TPD, neglecting other potentially important regions.…”

Cyclodextrins in the antiviral therapy

“…Polymeric CD composites work as smart components in drug delivery, though owing to their generally undefined structures, they are more suitable for topical application [52,95,96]. Although transdermal drug delivery is also the primary target of various polymeric CDs [97,98], no information is available in real applications. Dominantly the orally approved CDs and derivatives are still recommended for skin formulations [3].…”